4,5,6,7-Tetrahydro-1 H-Pyrazolo[4,3-C]Pyridin-3-Amine Compounds As Cbp And/Or Ep300 Inhibitors


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

ROMERO, F. ANTHONY , MAGNUSON, STEVEN , PASTOR, RICHARD , TSUI, VICKIE HSIAO-WEI , MURRAY, JEREMY , CRAWFORD, Terry , ALBRECHT, BRIAN, K. , COTE, ALEXANDRE , TAYLOR, ALEXANDER, M. , LAI, Kwong Wah , CHEN, KEVIN, X. , BRONNER, SARAH , ADLER, MARC , EGEN, Jackson , LIAO, Jiangpeng , WANG, FEI , Cyr, Patrick , ZHU, BING-YAN , KAUDER, Steven

ABSTRACT

The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R1-R3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders. More... »

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