Methods And Compositions For Improving Homing Of Cells Including Mesenchymal Stem Cells


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

BENHAMOU, Brigitte , BOQUET, Gerald , DELEUZE, JEAN-FRANCOIS , KARP, JEFFREY, M. , LEVY, OREN , LIN, CHARLES, P. , MORTENSEN, Luke, J. , PERRAULT, Christelle , ZHANG, JIDONG

ABSTRACT

The disclosure relates to methods and compositions for improving homing of cells including mesenchymal stem cells (MSCs). Compositions include compounds described herein as capable of inducing expression by MSCs of cell surface homing ligand molecules such as CD1 la, promoting increased firm adhesion by MSCs in an in vitro shear flow assay, increasing binding to an adhesion molecule such as E-selectin or ICAM-1, and/or demonstrating anti-inflammatory activity upon in vivo systemic administration in cell therapy using human MSCs. Also described are screening methods to identify small molecule compounds for improving a homing function of MSCs. More... »

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