Compositions And Methods Of Use Of Crispr-Cas Systems In Nucleotide Repeat Disorders


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

DAVIDSON, BEVERLY , LIN, Chie-yu , RODRIGUEZ, EDGARDO , ZHANG, FENG

ABSTRACT

The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences especially for use as to nucleotide repeat disorders. Provided are delivery systems and tissues or organ which are targeted as sites for delivery especially for use as to nucleotide repeat disorders. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex or system especially for use as to nucleotide repeat disorders, as well as methods for the design and of such. Also provided are methods of directing CRISPR complex or system formation in eukaryotic cells especially for use as to nucleotide repeat disorders including with consideration of specificity for target recognition and avoidance of toxicity and editing or modifying a target site in a genomic locus of interest to alter or improve the status of a disease or a condition. More... »

Related SciGraph Publications

  • 2013-11. Genome engineering using the CRISPR-Cas9 system in NATURE PROTOCOLS
  • 2008-07. Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases in NATURE BIOTECHNOLOGY
  • 2008-06. A protocol for constructing gene targeting vectors: generating knockout mice for the cadherin family and beyond in NATURE PROTOCOLS
  • 2010-11. The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA in NATURE
  • 2011-06. Evolution and classification of the CRISPR–Cas systems in NATURE REVIEWS MICROBIOLOGY
  • 2011-02. Expression of therapeutic proteins after delivery of chemically modified mRNA in mice in NATURE BIOTECHNOLOGY
  • 2012-01. A transcription activator-like effector toolbox for genome engineering in NATURE PROTOCOLS
  • 2011-02. Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription in NATURE BIOTECHNOLOGY
  • 2011-02. A TALE nuclease architecture for efficient genome editing in NATURE BIOTECHNOLOGY
  • 2007-07. An improved zinc-finger nuclease architecture for highly specific genome editing in NATURE BIOTECHNOLOGY
  • 1985-09. Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination in NATURE
  • 2012-11-15. Exosome-mediated delivery of siRNA in vitro and in vivo in NATURE PROTOCOLS
  • 2009-10. Molecular signatures of disease brain endothelia provide new sites for CNS-directed enzyme therapy in NATURE MEDICINE
  • 2005-10. Adeno-associated virus type 4 (AAV4) targets ependyma and astrocytes in the subventricular zone and RMS in GENE THERAPY
  • 2002-05. Expanding small RNA interference in NATURE BIOTECHNOLOGY
  • 2011-03. CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III in NATURE
  • 2010-09. Genome editing with engineered zinc finger nucleases in NATURE REVIEWS GENETICS
  • 2012-05. FLASH assembly of TALENs for high-throughput genome editing in NATURE BIOTECHNOLOGY
  • 2013-03. RNA-guided editing of bacterial genomes using CRISPR-Cas systems in NATURE BIOTECHNOLOGY
  • 2011-01. Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA) in NATURE METHODS
  • 2013-03. Efficient genome editing in zebrafish using a CRISPR-Cas system in NATURE BIOTECHNOLOGY
  • 2013-05. Generation of gene-modified mice via Cas9/RNA-mediated gene targeting in CELL RESEARCH
  • 2013-03. Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease in NATURE BIOTECHNOLOGY
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2620", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "name": "DAVIDSON, BEVERLY", 
            "type": "Person"
          }, 
          {
            "name": "LIN, Chie-yu", 
            "type": "Person"
          }, 
          {
            "name": "RODRIGUEZ, EDGARDO", 
            "type": "Person"
          }, 
          {
            "name": "ZHANG, FENG", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1006/mthe.2001.0512", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000805362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1211446109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000972509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.76.15.7651-7660.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001339941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001863376", 
              "https://doi.org/10.1038/nm.2025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002080286", 
              "https://doi.org/10.1038/nbt.1733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002154526", 
              "https://doi.org/10.1038/nbt1319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.08.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002481722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymeth.2010.12.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003625224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1078395", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003888273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(81)90522-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003990062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.02.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004290844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.micro.112408.134123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005066090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/317230a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005647127", 
              "https://doi.org/10.1038/317230a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/mt.2012.100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005759032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2009.12.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006614775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/genetics.110.120717", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007578180"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.02.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008291683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09523", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009515358", 
              "https://doi.org/10.1038/nature09523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.c112.408864", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010519218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1208507109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011954581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jim.2011.10.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012858181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-genet-110410-132430", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013432136"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(86)90463-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013895330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.04.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013935649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1019533108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014623209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1178811", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014803320"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2796.2009.02189.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015446315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1755", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016004947", 
              "https://doi.org/10.1038/nbt.1755"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2013.143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016534425", 
              "https://doi.org/10.1038/nprot.2013.143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1172447", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016732447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2012.131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017288792", 
              "https://doi.org/10.1038/nprot.2012.131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-5193(86)80075-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017782718"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2842", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018939216", 
              "https://doi.org/10.1038/nrg2842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1231143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019873131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2508", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019888616", 
              "https://doi.org/10.1038/nbt.2508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrmicro2577", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020345829", 
              "https://doi.org/10.1038/nrmicro2577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/adfm.200900519", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020373263"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2011.431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020679703", 
              "https://doi.org/10.1038/nprot.2011.431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.09.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021453389"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2008.70", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021659054", 
              "https://doi.org/10.1038/nprot.2008.70"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.11.11.5586", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021671685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1179555", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022007081"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1232033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022072971"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/mp100390w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022862092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkr597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023270535"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2501", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024988605", 
              "https://doi.org/10.1038/nbt.2501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/mt.2009.123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025360850"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/28.1.292", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027297769"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.74.8.3852-3858.2000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027649487"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1542", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028726583", 
              "https://doi.org/10.1038/nmeth.1542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jps.23377", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028800465"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2012.11.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030194691"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09886", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030591890", 
              "https://doi.org/10.1038/nature09886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1775", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031104364", 
              "https://doi.org/10.1038/nbt.1775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0502-446", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036940895", 
              "https://doi.org/10.1038/nbt0502-446"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkh703", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037323895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2013.46", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038811201", 
              "https://doi.org/10.1038/cr.2013.46"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.05.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039182708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2170", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040026920", 
              "https://doi.org/10.1038/nbt.2170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ibmb.2010.07.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041467501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1225829", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041850060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2507", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041881936", 
              "https://doi.org/10.1038/nbt.2507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gks199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043538526"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1246981", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043810806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(07)60982-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044942622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302554", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045089110", 
              "https://doi.org/10.1038/sj.gt.3302554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1410", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048577624", 
              "https://doi.org/10.1038/nbt1410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(95)90273-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049965810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.06.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052083829"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkr606", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052438070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cn300089k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053961689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/10430340260355347", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059202444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/104303403322542301", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059202581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/hum.2010.245", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059273619"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1207773", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062464819"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "description": "

    The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences especially for use as to nucleotide repeat disorders. Provided are delivery systems and tissues or organ which are targeted as sites for delivery especially for use as to nucleotide repeat disorders. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex or system especially for use as to nucleotide repeat disorders, as well as methods for the design and of such. Also provided are methods of directing CRISPR complex or system formation in eukaryotic cells especially for use as to nucleotide repeat disorders including with consideration of specificity for target recognition and avoidance of toxicity and editing or modifying a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

    ", "id": "sg:patent.WO-2015089354-A1", "keywords": [ "composition", "nucleotide", "invention", "delivery", "optimization", "method", "manipulation", "sequence", "target sequence", "delivery system", "tissue", "organ", "vector", "vector system", "component", "complex", "eukaryotic cell", "consideration", "Sensitivity and Specificity", "target recognition", "avoidance", "toxicity", "editing", "target site", "genomic locus", "status", "disease", "condition" ], "name": "COMPOSITIONS AND METHODS OF USE OF CRISPR-CAS SYSTEMS IN NUCLEOTIDE REPEAT DISORDERS", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.66859.34", "type": "Organization" }, { "id": "https://www.grid.ac/institutes/grid.116068.8", "type": "Organization" }, { "id": "https://www.grid.ac/institutes/grid.214572.7", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/WO-2015089354-A1" ], "sdDataset": "patents", "sdDatePublished": "2019-03-07T15:36", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com.uberresearch.data.dev.patents-pipeline/full_run_10/sn-export/5eb3e5a348d7f117b22cc85fb0b02730/0000100128-0000348334/json_export_c290c18d.jsonl", "type": "Patent" } ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.WO-2015089354-A1'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.WO-2015089354-A1'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.WO-2015089354-A1'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.WO-2015089354-A1'


     

    This table displays all metadata directly associated to this object as RDF triples.

    313 TRIPLES      14 PREDICATES      118 URIs      35 LITERALS      2 BLANK NODES

    Subject Predicate Object
    1 sg:patent.WO-2015089354-A1 schema:about anzsrc-for:2620
    2 schema:author Nc4ee717ce2d94ac3aca281d606250d74
    3 schema:citation sg:pub.10.1038/317230a0
    4 sg:pub.10.1038/cr.2013.46
    5 sg:pub.10.1038/nature09523
    6 sg:pub.10.1038/nature09886
    7 sg:pub.10.1038/nbt.1733
    8 sg:pub.10.1038/nbt.1755
    9 sg:pub.10.1038/nbt.1775
    10 sg:pub.10.1038/nbt.2170
    11 sg:pub.10.1038/nbt.2501
    12 sg:pub.10.1038/nbt.2507
    13 sg:pub.10.1038/nbt.2508
    14 sg:pub.10.1038/nbt0502-446
    15 sg:pub.10.1038/nbt1319
    16 sg:pub.10.1038/nbt1410
    17 sg:pub.10.1038/nm.2025
    18 sg:pub.10.1038/nmeth.1542
    19 sg:pub.10.1038/nprot.2008.70
    20 sg:pub.10.1038/nprot.2011.431
    21 sg:pub.10.1038/nprot.2012.131
    22 sg:pub.10.1038/nprot.2013.143
    23 sg:pub.10.1038/nrg2842
    24 sg:pub.10.1038/nrmicro2577
    25 sg:pub.10.1038/sj.gt.3302554
    26 https://doi.org/10.1002/adfm.200900519
    27 https://doi.org/10.1002/jps.23377
    28 https://doi.org/10.1006/mthe.2001.0512
    29 https://doi.org/10.1016/0092-8674(81)90522-5
    30 https://doi.org/10.1016/0092-8674(86)90463-0
    31 https://doi.org/10.1016/0092-8674(95)90273-2
    32 https://doi.org/10.1016/j.cell.2011.06.019
    33 https://doi.org/10.1016/j.cell.2013.02.022
    34 https://doi.org/10.1016/j.cell.2013.04.025
    35 https://doi.org/10.1016/j.cell.2013.08.021
    36 https://doi.org/10.1016/j.cell.2014.02.001
    37 https://doi.org/10.1016/j.cell.2014.05.010
    38 https://doi.org/10.1016/j.cell.2014.09.014
    39 https://doi.org/10.1016/j.ibmb.2010.07.012
    40 https://doi.org/10.1016/j.jim.2011.10.007
    41 https://doi.org/10.1016/j.molcel.2009.12.033
    42 https://doi.org/10.1016/j.stem.2012.11.011
    43 https://doi.org/10.1016/j.ymeth.2010.12.019
    44 https://doi.org/10.1016/s0022-5193(86)80075-3
    45 https://doi.org/10.1016/s0140-6736(07)60982-9
    46 https://doi.org/10.1021/cn300089k
    47 https://doi.org/10.1021/mp100390w
    48 https://doi.org/10.1038/mt.2009.123
    49 https://doi.org/10.1038/mt.2012.100
    50 https://doi.org/10.1073/pnas.1019533108
    51 https://doi.org/10.1073/pnas.1208507109
    52 https://doi.org/10.1073/pnas.1211446109
    53 https://doi.org/10.1074/jbc.c112.408864
    54 https://doi.org/10.1089/10430340260355347
    55 https://doi.org/10.1089/104303403322542301
    56 https://doi.org/10.1089/hum.2010.245
    57 https://doi.org/10.1093/nar/28.1.292
    58 https://doi.org/10.1093/nar/gkh703
    59 https://doi.org/10.1093/nar/gkr597
    60 https://doi.org/10.1093/nar/gkr606
    61 https://doi.org/10.1093/nar/gks199
    62 https://doi.org/10.1111/j.1365-2796.2009.02189.x
    63 https://doi.org/10.1126/science.1078395
    64 https://doi.org/10.1126/science.1172447
    65 https://doi.org/10.1126/science.1178811
    66 https://doi.org/10.1126/science.1179555
    67 https://doi.org/10.1126/science.1207773
    68 https://doi.org/10.1126/science.1225829
    69 https://doi.org/10.1126/science.1231143
    70 https://doi.org/10.1126/science.1232033
    71 https://doi.org/10.1126/science.1246981
    72 https://doi.org/10.1128/jvi.74.8.3852-3858.2000
    73 https://doi.org/10.1128/jvi.76.15.7651-7660.2002
    74 https://doi.org/10.1128/mcb.11.11.5586
    75 https://doi.org/10.1146/annurev-genet-110410-132430
    76 https://doi.org/10.1146/annurev.micro.112408.134123
    77 https://doi.org/10.1534/genetics.110.120717
    78 schema:description <p num="0000">The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences especially for use as to nucleotide repeat disorders. Provided are delivery systems and tissues or organ which are targeted as sites for delivery especially for use as to nucleotide repeat disorders. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex or system especially for use as to nucleotide repeat disorders, as well as methods for the design and of such. Also provided are methods of directing CRISPR complex or system formation in eukaryotic cells especially for use as to nucleotide repeat disorders including with consideration of specificity for target recognition and avoidance of toxicity and editing or modifying a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.</p>
    79 schema:keywords Sensitivity and Specificity
    80 avoidance
    81 complex
    82 component
    83 composition
    84 condition
    85 consideration
    86 delivery
    87 delivery system
    88 disease
    89 editing
    90 eukaryotic cell
    91 genomic locus
    92 invention
    93 manipulation
    94 method
    95 nucleotide
    96 optimization
    97 organ
    98 sequence
    99 status
    100 target recognition
    101 target sequence
    102 target site
    103 tissue
    104 toxicity
    105 vector
    106 vector system
    107 schema:name COMPOSITIONS AND METHODS OF USE OF CRISPR-CAS SYSTEMS IN NUCLEOTIDE REPEAT DISORDERS
    108 schema:recipient https://www.grid.ac/institutes/grid.116068.8
    109 https://www.grid.ac/institutes/grid.214572.7
    110 https://www.grid.ac/institutes/grid.66859.34
    111 schema:sameAs https://app.dimensions.ai/details/patent/WO-2015089354-A1
    112 schema:sdDatePublished 2019-03-07T15:36
    113 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    114 schema:sdPublisher N94afef50ebc047cc8450ff2dd051811c
    115 sgo:license sg:explorer/license/
    116 sgo:sdDataset patents
    117 rdf:type sgo:Patent
    118 N0067e5867b3c48a3aeba70f31809b784 rdf:first N843321493e2e40d2b99e8ccb161c1568
    119 rdf:rest N1da3028c40d441a5880e7e07092b98a8
    120 N0dcfeac732d346689799893b0b78d771 rdf:first N670f156c430e4e1f97afb1621f45cf54
    121 rdf:rest rdf:nil
    122 N1da3028c40d441a5880e7e07092b98a8 rdf:first Nfd6a2cc8f0974c66a3c94f201a830899
    123 rdf:rest N0dcfeac732d346689799893b0b78d771
    124 N4d0107b3188a451daf969e4a4f5ffc33 schema:name DAVIDSON, BEVERLY
    125 rdf:type schema:Person
    126 N670f156c430e4e1f97afb1621f45cf54 schema:name ZHANG, FENG
    127 rdf:type schema:Person
    128 N843321493e2e40d2b99e8ccb161c1568 schema:name LIN, Chie-yu
    129 rdf:type schema:Person
    130 N94afef50ebc047cc8450ff2dd051811c schema:name Springer Nature - SN SciGraph project
    131 rdf:type schema:Organization
    132 Nc4ee717ce2d94ac3aca281d606250d74 rdf:first N4d0107b3188a451daf969e4a4f5ffc33
    133 rdf:rest N0067e5867b3c48a3aeba70f31809b784
    134 Nfd6a2cc8f0974c66a3c94f201a830899 schema:name RODRIGUEZ, EDGARDO
    135 rdf:type schema:Person
    136 anzsrc-for:2620 schema:inDefinedTermSet anzsrc-for:
    137 rdf:type schema:DefinedTerm
    138 sg:pub.10.1038/317230a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005647127
    139 https://doi.org/10.1038/317230a0
    140 rdf:type schema:CreativeWork
    141 sg:pub.10.1038/cr.2013.46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038811201
    142 https://doi.org/10.1038/cr.2013.46
    143 rdf:type schema:CreativeWork
    144 sg:pub.10.1038/nature09523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009515358
    145 https://doi.org/10.1038/nature09523
    146 rdf:type schema:CreativeWork
    147 sg:pub.10.1038/nature09886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030591890
    148 https://doi.org/10.1038/nature09886
    149 rdf:type schema:CreativeWork
    150 sg:pub.10.1038/nbt.1733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002080286
    151 https://doi.org/10.1038/nbt.1733
    152 rdf:type schema:CreativeWork
    153 sg:pub.10.1038/nbt.1755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016004947
    154 https://doi.org/10.1038/nbt.1755
    155 rdf:type schema:CreativeWork
    156 sg:pub.10.1038/nbt.1775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031104364
    157 https://doi.org/10.1038/nbt.1775
    158 rdf:type schema:CreativeWork
    159 sg:pub.10.1038/nbt.2170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040026920
    160 https://doi.org/10.1038/nbt.2170
    161 rdf:type schema:CreativeWork
    162 sg:pub.10.1038/nbt.2501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024988605
    163 https://doi.org/10.1038/nbt.2501
    164 rdf:type schema:CreativeWork
    165 sg:pub.10.1038/nbt.2507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041881936
    166 https://doi.org/10.1038/nbt.2507
    167 rdf:type schema:CreativeWork
    168 sg:pub.10.1038/nbt.2508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019888616
    169 https://doi.org/10.1038/nbt.2508
    170 rdf:type schema:CreativeWork
    171 sg:pub.10.1038/nbt0502-446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036940895
    172 https://doi.org/10.1038/nbt0502-446
    173 rdf:type schema:CreativeWork
    174 sg:pub.10.1038/nbt1319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002154526
    175 https://doi.org/10.1038/nbt1319
    176 rdf:type schema:CreativeWork
    177 sg:pub.10.1038/nbt1410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048577624
    178 https://doi.org/10.1038/nbt1410
    179 rdf:type schema:CreativeWork
    180 sg:pub.10.1038/nm.2025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001863376
    181 https://doi.org/10.1038/nm.2025
    182 rdf:type schema:CreativeWork
    183 sg:pub.10.1038/nmeth.1542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028726583
    184 https://doi.org/10.1038/nmeth.1542
    185 rdf:type schema:CreativeWork
    186 sg:pub.10.1038/nprot.2008.70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021659054
    187 https://doi.org/10.1038/nprot.2008.70
    188 rdf:type schema:CreativeWork
    189 sg:pub.10.1038/nprot.2011.431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020679703
    190 https://doi.org/10.1038/nprot.2011.431
    191 rdf:type schema:CreativeWork
    192 sg:pub.10.1038/nprot.2012.131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017288792
    193 https://doi.org/10.1038/nprot.2012.131
    194 rdf:type schema:CreativeWork
    195 sg:pub.10.1038/nprot.2013.143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016534425
    196 https://doi.org/10.1038/nprot.2013.143
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1038/nrg2842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018939216
    199 https://doi.org/10.1038/nrg2842
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1038/nrmicro2577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020345829
    202 https://doi.org/10.1038/nrmicro2577
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1038/sj.gt.3302554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045089110
    205 https://doi.org/10.1038/sj.gt.3302554
    206 rdf:type schema:CreativeWork
    207 https://doi.org/10.1002/adfm.200900519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020373263
    208 rdf:type schema:CreativeWork
    209 https://doi.org/10.1002/jps.23377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028800465
    210 rdf:type schema:CreativeWork
    211 https://doi.org/10.1006/mthe.2001.0512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000805362
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.1016/0092-8674(81)90522-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003990062
    214 rdf:type schema:CreativeWork
    215 https://doi.org/10.1016/0092-8674(86)90463-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013895330
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.1016/0092-8674(95)90273-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049965810
    218 rdf:type schema:CreativeWork
    219 https://doi.org/10.1016/j.cell.2011.06.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052083829
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1016/j.cell.2013.02.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008291683
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1016/j.cell.2013.04.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013935649
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1016/j.cell.2013.08.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002481722
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1016/j.cell.2014.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004290844
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1016/j.cell.2014.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039182708
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1016/j.cell.2014.09.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021453389
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1016/j.ibmb.2010.07.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041467501
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1016/j.jim.2011.10.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012858181
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1016/j.molcel.2009.12.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006614775
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1016/j.stem.2012.11.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030194691
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1016/j.ymeth.2010.12.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003625224
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1016/s0022-5193(86)80075-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017782718
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1016/s0140-6736(07)60982-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044942622
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1021/cn300089k schema:sameAs https://app.dimensions.ai/details/publication/pub.1053961689
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1021/mp100390w schema:sameAs https://app.dimensions.ai/details/publication/pub.1022862092
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1038/mt.2009.123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025360850
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1038/mt.2012.100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005759032
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1073/pnas.1019533108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014623209
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1073/pnas.1208507109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011954581
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1073/pnas.1211446109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000972509
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1074/jbc.c112.408864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010519218
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1089/10430340260355347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059202444
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1089/104303403322542301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059202581
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1089/hum.2010.245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059273619
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1093/nar/28.1.292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027297769
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1093/nar/gkh703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037323895
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1093/nar/gkr597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023270535
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1093/nar/gkr606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052438070
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1093/nar/gks199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043538526
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1111/j.1365-2796.2009.02189.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015446315
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1126/science.1078395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003888273
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1126/science.1172447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016732447
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1126/science.1178811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014803320
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1126/science.1179555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022007081
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1126/science.1207773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062464819
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1126/science.1225829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041850060
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1126/science.1231143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019873131
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1126/science.1232033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022072971
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1126/science.1246981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043810806
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1128/jvi.74.8.3852-3858.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027649487
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1128/jvi.76.15.7651-7660.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001339941
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1128/mcb.11.11.5586 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021671685
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1146/annurev-genet-110410-132430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013432136
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1146/annurev.micro.112408.134123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005066090
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1534/genetics.110.120717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007578180
    310 rdf:type schema:CreativeWork
    311 https://www.grid.ac/institutes/grid.116068.8 schema:Organization
    312 https://www.grid.ac/institutes/grid.214572.7 schema:Organization
    313 https://www.grid.ac/institutes/grid.66859.34 schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...