Genome Modification Using Guide Polynucleotide/Cas Endonuclease Systems And Methods Of Use


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

CIGAN, ANDREW , PATTEN, PHILLIP, A. , YOUNG, JOSHUA, K.

ABSTRACT

Compositions and methods are provided for genome modification of a target sequence in the genome of a cell. The methods and compositions employ a guide polynucleotide/Cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a cell or organism. Once a genomic target site is identified, a variety of methods can be employed to further modify the target sites such that they contain a variety of polynucleotides of interest. Compositions and methods are also provided for editing a nucleotide sequence in the genome of a cell. Breeding methods and methods for selecting plants utilizing a two component RNA polynucleotide and Cas endonuclease system are also disclosed. More... »

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