Stabilized Gp120


Ontology type: sgo:Patent     


Patent Info

DATE

2013-12-27T00:00

AUTHORS

CARFI, ANDREA , DEY, Antu , KASSA, Aemro , SRIVASTAVA, INDRESH

ABSTRACT

The present invention provides an isolated polypeptide comprising an HIV gp120 polypeptideor soluble gp140 polypeptidestabilized in a conformation which exposes both CD4-bound and CD4- binding site epitopes. The invention also provides immunogenic compositions and methods of treating and preventing infection with HIV.

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