Methods And Compounds For Treating Diseases


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

ANDERSSON, JOHN , MAILER, Reiner Karl Walter

ABSTRACT

The present invention provides a method for amplifying an immune response in an individual, comprising altering the composition of FoxP3 isoforms by inducing an expression of a FoxP3 isoform, such as FoxP3d2d7, that inhibits the function of FoxP3fl and/or FoxP3d2, and a method for treating a cancer or an infection or for inducing an increased vaccine response in an individual, comprising amplifying an immune response in said individual, compounds for use in such methods, pharmaceutical compositions, and a method for in vitro testing of a candidate medicinal product. The invention further relates to a method for diagnosing inflammatory bowel disease (IBD) in an individual, and use of FoxP3d2d7 as a diagnostic marker for IBD. More... »

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