Reprogramming Effector Protein Interactions To Correct Epigenetic Defects In Cancer


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

JONES, Steven J.M. , YAKOVENKO, Oleksandr , THOENE, Silvia , CHEUNG, Pierre Yulmin , AN, JIANGHONG

ABSTRACT

Methods of "reprogramming" epigenetic mark readers or erasers to recognize epigenetic marks other than their cognate (or natural) marks are provided. Reprogramming the reader or eraser can offset the effects of aberrant writer activity (for example, loss of function or overactivity) that can contribute to certain diseases states, such as cancer. The use of the reprogramming compounds identified by these methods in the treatment of such disease states is also provided. Exemplary mark readers that can be targeted by these methods include BPTF and CBX2. More... »

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