Use Of Igf-1 In The Modulation Of Treg Cell Activity And The Treatment And Prevention Of Autoimmune Disorders Or Diseases


Ontology type: sgo:Patent     


Patent Info

DATE

2013-04-11T00:00

AUTHORS

BILBAO CORTES, Daniel , LUCIANI, Luisa , ROSENTHAL, NADIA

ABSTRACT

The present invention relates to the use of the Insulin-like growth factor-I (IGF-1) in immune modulation and/or in the treatment or prevention of pathogenic or aberrant immune responses or disorders and/or for use in the treatment or prevention of T-cell mediated disorders or diseases and/or for use in the treatment or prevention of diseases where the immune system contributes to the disease state. More... »

Related SciGraph Publications

  • 2005-02. Tolerance, suppression and the fetal allograft in JOURNAL OF MOLECULAR MEDICINE
  • 2006-09. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17–producing T cells in NATURE IMMUNOLOGY
  • 2007-09. Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3− precursor cells in the absence of interleukin 10 in NATURE IMMUNOLOGY
  • 2006-10. Application of cellular gene therapy for rheumatoid arthritis in MODERN RHEUMATOLOGY
  • 2001-09. Regulatory T cells in the control of immune pathology in NATURE IMMUNOLOGY
  • 2007-02. Regulatory mechanisms of the immune system in multiple sclerosis. T regulatory cells: turned on to turn off in JOURNAL OF NEUROLOGY
  • 2002-07. Long-Circulating Poly(Ethylene Glycol)-Modified Gelatin Nanoparticles for Intracellular Delivery in PHARMACEUTICAL RESEARCH
  • 2003-04. An essential role for Scurfin in CD4+CD25+ T regulatory cells in NATURE IMMUNOLOGY
  • 2011-05. B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies in NATURE MEDICINE
  • 2005-04. Natural regulatory T cells in infectious disease in NATURE IMMUNOLOGY
  • 2003-04. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells in NATURE IMMUNOLOGY
  • 2008-10. An evaluation of the effects of gatifloxacin on glucose homeostasis in INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
  • 2012-12. Hematopoietic stem cell transplantation induces immunologic tolerance in renal transplant patients via modulation of inflammatory and repair processes in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2005-06. Tumor-Targeted Gene Delivery Using Poly(Ethylene Glycol)-Modified Gelatin Nanoparticles: In Vitro and in Vivo Studies in PHARMACEUTICAL RESEARCH
  • 2010-07. FOXP3+ regulatory T cells in the human immune system in NATURE REVIEWS IMMUNOLOGY
  • 2009-08. Normalization of obesity-associated insulin resistance through immunotherapy in NATURE MEDICINE
  • 1999-07. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA in GENE THERAPY
  • 2010-01. Regulatory T cells exert checks and balances on self tolerance and autoimmunity in NATURE IMMUNOLOGY
  • 2009-08. T time in the brain in NATURE MEDICINE
  • 2000-06. Immuno- and genetic therapy in autoimmune diseases in GENES & IMMUNITY
  • 2013-12. Identification of serum insulin-like growth factor binding protein 1 as diagnostic biomarker for early-stage alcohol-induced liver disease in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2008-12. Epidermal Growth Factor Receptor-Targeted Gelatin-Based Engineered Nanocarriers for DNA Delivery and Transfection in Human Pancreatic Cancer Cells in THE AAPS JOURNAL
  • 2007-04. Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation in NATURE MEDICINE
  • 2009-08. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity in NATURE MEDICINE
  • 2013-01. Clinical utility of quantitative HBsAg in natural history and nucleos(t)ide analogue treatment of chronic hepatitis B: new trick of old dog in JOURNAL OF GASTROENTEROLOGY
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3053", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "name": "BILBAO CORTES, Daniel", 
            "type": "Person"
          }, 
          {
            "name": "LUCIANI, Luisa", 
            "type": "Person"
          }, 
          {
            "name": "ROSENTHAL, NADIA", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1111/j.1365-2222.2009.03301.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000268313"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1504", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000494859", 
              "https://doi.org/10.1038/ni1504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00535-012-0668-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000573532", 
              "https://doi.org/10.1007/s00535-012-0668-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830250411", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001813212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0091-6749(97)70006-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002231464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.jvca.2015.05.198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003073387"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003810856", 
              "https://doi.org/10.1038/nm.2001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003810856", 
              "https://doi.org/10.1038/nm.2001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.26.15603", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004157296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2353/ajpath.2010.090759", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005780751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/db06-0328", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008504650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2785", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009921186", 
              "https://doi.org/10.1038/nri2785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2785", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009921186", 
              "https://doi.org/10.1038/nri2785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/mp.54.4.227", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011602568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/mp.54.4.227", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011602568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cyto.a.20659", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011769597"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200105147", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012924704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1479-5876-10-182", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014010677", 
              "https://doi.org/10.1186/1479-5876-10-182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2003-01-0100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014015431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2010.02.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015811420"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.intimp.2010.11.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017139999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.92.13.6190", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017517603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200108071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017578270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1818", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018345956", 
              "https://doi.org/10.1038/ni.1818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1818", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018345956", 
              "https://doi.org/10.1038/ni.1818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.1964", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018401818", 
              "https://doi.org/10.1038/nm.1964"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.1964", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018401818", 
              "https://doi.org/10.1038/nm.1964"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0303792101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019561902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/mcne.1994.1052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020787039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00415-007-1003-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022968398", 
              "https://doi.org/10.1007/s00415-007-1003-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00415-007-1003-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022968398", 
              "https://doi.org/10.1007/s00415-007-1003-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1208/s12248-008-9065-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025571201", 
              "https://doi.org/10.1208/s12248-008-9065-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2005.10.040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026476846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1375", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026540507", 
              "https://doi.org/10.1038/ni1375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1375", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026540507", 
              "https://doi.org/10.1038/ni1375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.21.120601.141122", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027044744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni0901-816", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027284442", 
              "https://doi.org/10.1038/ni0901-816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni0901-816", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027284442", 
              "https://doi.org/10.1038/ni0901-816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1471-4906(00)01815-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027338906"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1564", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028110690", 
              "https://doi.org/10.1038/nm1564"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00109-004-0608-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028707088", 
              "https://doi.org/10.1007/s00109-004-0608-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1201475", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028801106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10165-006-0501-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030190312", 
              "https://doi.org/10.1007/s10165-006-0501-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030246788", 
              "https://doi.org/10.1038/nm.2353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20030686", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030332792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11096-008-9205-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030409713", 
              "https://doi.org/10.1007/s11096-008-9205-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3300947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030560074", 
              "https://doi.org/10.1038/sj.gt.3300947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3300947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030560074", 
              "https://doi.org/10.1038/sj.gt.3300947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032222092", 
              "https://doi.org/10.1038/ni909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032222092", 
              "https://doi.org/10.1038/ni909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0026-0495(78)90267-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033275031"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1106442", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033734963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molimm.2009.07.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035818869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.24.021605.090547", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036861938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.24.021605.090547", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036861938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/156652309788488569", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037072466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5021/ad.2010.22.4.397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041010573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5021/ad.2010.22.4.397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041010573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1016486910719", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041254126", 
              "https://doi.org/10.1023/a:1016486910719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11095-005-4590-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041724590", 
              "https://doi.org/10.1007/s11095-005-4590-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11095-005-4590-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041724590", 
              "https://doi.org/10.1007/s11095-005-4590-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1479-5876-11-266", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042013879", 
              "https://doi.org/10.1186/1479-5876-11-266"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/pr.109.002469", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043685345"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1181", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044334928", 
              "https://doi.org/10.1038/ni1181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1181", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044334928", 
              "https://doi.org/10.1038/ni1181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gene.6363683", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045483367", 
              "https://doi.org/10.1038/sj.gene.6363683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gene.6363683", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045483367", 
              "https://doi.org/10.1038/sj.gene.6363683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1079490", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047445436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jri.2010.02.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048103109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0809-844", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049583443", 
              "https://doi.org/10.1038/nm0809-844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0809-844", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049583443", 
              "https://doi.org/10.1038/nm0809-844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/diabetes.52.10.2483", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051160498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1468-1331.2003.00638.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053106208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni904", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053106484", 
              "https://doi.org/10.1038/ni904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni904", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053106484", 
              "https://doi.org/10.1038/ni904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nmd.2007.06.466", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053273057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci1486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053329241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0008-8749(88)90225-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053371718"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1055/s-2003-41137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1057423521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.180605", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062507737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.332.6033.1020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062607053"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/er.15.1.5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064285636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/er.21.3.292", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064286137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.23-20-07710.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075335935"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.181.10.6942", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077805381"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-04-11T00:00", 
        "description": "

    The present invention relates to the use of the Insulin-like growth factor-I (IGF-1) in immune modulation and/or in the treatment or prevention of pathogenic or aberrant immune responses or disorders and/or for use in the treatment or prevention of T-cell mediated disorders or diseases and/or for use in the treatment or prevention of diseases where the immune system contributes to the disease state.

    ", "id": "sg:patent.WO-2013050529-A2", "keywords": [ "IGF", "cell activity", "autoimmune disorder", "invention", "insulin-like growth", "Insulin-Like Growth Factor I", "immune modulation", "prevention", "aberrant immune response", "disorder", "T cell", "disease", "immune system", "disease state" ], "name": "USE OF IGF-1 IN THE MODULATION OF TREG CELL ACTIVITY AND THE TREATMENT AND PREVENTION OF AUTOIMMUNE DISORDERS OR DISEASES", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.4709.a", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/WO-2013050529-A2" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:10", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_00500.jsonl", "type": "Patent" } ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.WO-2013050529-A2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.WO-2013050529-A2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.WO-2013050529-A2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.WO-2013050529-A2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    276 TRIPLES      15 PREDICATES      97 URIs      22 LITERALS      2 BLANK NODES

    Subject Predicate Object
    1 sg:patent.WO-2013050529-A2 schema:about anzsrc-for:3053
    2 anzsrc-for:3103
    3 schema:author N740a23bfbd864226bafbbcba8c83ff6a
    4 schema:citation sg:pub.10.1007/s00109-004-0608-2
    5 sg:pub.10.1007/s00415-007-1003-z
    6 sg:pub.10.1007/s00535-012-0668-y
    7 sg:pub.10.1007/s10165-006-0501-7
    8 sg:pub.10.1007/s11095-005-4590-3
    9 sg:pub.10.1007/s11096-008-9205-8
    10 sg:pub.10.1023/a:1016486910719
    11 sg:pub.10.1038/ni.1818
    12 sg:pub.10.1038/ni0901-816
    13 sg:pub.10.1038/ni1181
    14 sg:pub.10.1038/ni1375
    15 sg:pub.10.1038/ni1504
    16 sg:pub.10.1038/ni904
    17 sg:pub.10.1038/ni909
    18 sg:pub.10.1038/nm.1964
    19 sg:pub.10.1038/nm.2001
    20 sg:pub.10.1038/nm.2353
    21 sg:pub.10.1038/nm0809-844
    22 sg:pub.10.1038/nm1564
    23 sg:pub.10.1038/nri2785
    24 sg:pub.10.1038/sj.gene.6363683
    25 sg:pub.10.1038/sj.gt.3300947
    26 sg:pub.10.1186/1479-5876-10-182
    27 sg:pub.10.1186/1479-5876-11-266
    28 sg:pub.10.1208/s12248-008-9065-0
    29 https://doi.org/10.1002/cyto.a.20659
    30 https://doi.org/10.1002/eji.1830250411
    31 https://doi.org/10.1006/mcne.1994.1052
    32 https://doi.org/10.1016/0008-8749(88)90225-0
    33 https://doi.org/10.1016/0026-0495(78)90267-6
    34 https://doi.org/10.1016/j.cell.2010.02.016
    35 https://doi.org/10.1016/j.intimp.2010.11.034
    36 https://doi.org/10.1016/j.jaci.2005.10.040
    37 https://doi.org/10.1016/j.jri.2010.02.006
    38 https://doi.org/10.1016/j.molimm.2009.07.003
    39 https://doi.org/10.1016/j.nmd.2007.06.466
    40 https://doi.org/10.1016/s0091-6749(97)70006-x
    41 https://doi.org/10.1016/s1471-4906(00)01815-9
    42 https://doi.org/10.1046/j.1468-1331.2003.00638.x
    43 https://doi.org/10.1053/j.jvca.2015.05.198
    44 https://doi.org/10.1055/s-2003-41137
    45 https://doi.org/10.1073/pnas.0303792101
    46 https://doi.org/10.1073/pnas.92.13.6190
    47 https://doi.org/10.1073/pnas.95.26.15603
    48 https://doi.org/10.1083/jcb.200105147
    49 https://doi.org/10.1083/jcb.200108071
    50 https://doi.org/10.1084/jem.20030686
    51 https://doi.org/10.1111/j.1365-2222.2009.03301.x
    52 https://doi.org/10.1124/pr.109.002469
    53 https://doi.org/10.1126/science.1079490
    54 https://doi.org/10.1126/science.1106442
    55 https://doi.org/10.1126/science.1201475
    56 https://doi.org/10.1126/science.180605
    57 https://doi.org/10.1126/science.332.6033.1020
    58 https://doi.org/10.1136/mp.54.4.227
    59 https://doi.org/10.1146/annurev.immunol.21.120601.141122
    60 https://doi.org/10.1146/annurev.immunol.24.021605.090547
    61 https://doi.org/10.1172/jci1486
    62 https://doi.org/10.1182/blood-2003-01-0100
    63 https://doi.org/10.1210/er.15.1.5
    64 https://doi.org/10.1210/er.21.3.292
    65 https://doi.org/10.1523/jneurosci.23-20-07710.2003
    66 https://doi.org/10.2174/156652309788488569
    67 https://doi.org/10.2337/db06-0328
    68 https://doi.org/10.2337/diabetes.52.10.2483
    69 https://doi.org/10.2353/ajpath.2010.090759
    70 https://doi.org/10.4049/jimmunol.181.10.6942
    71 https://doi.org/10.5021/ad.2010.22.4.397
    72 schema:datePublished 2013-04-11T00:00
    73 schema:description <p>The present invention relates to the use of the Insulin-like growth factor-I (IGF-1) in immune modulation and/or in the treatment or prevention of pathogenic or aberrant immune responses or disorders and/or for use in the treatment or prevention of T-cell mediated disorders or diseases and/or for use in the treatment or prevention of diseases where the immune system contributes to the disease state.</p>
    74 schema:keywords IGF
    75 Insulin-Like Growth Factor I
    76 T cell
    77 aberrant immune response
    78 autoimmune disorder
    79 cell activity
    80 disease
    81 disease state
    82 disorder
    83 immune modulation
    84 immune system
    85 insulin-like growth
    86 invention
    87 prevention
    88 schema:name USE OF IGF-1 IN THE MODULATION OF TREG CELL ACTIVITY AND THE TREATMENT AND PREVENTION OF AUTOIMMUNE DISORDERS OR DISEASES
    89 schema:recipient https://www.grid.ac/institutes/grid.4709.a
    90 schema:sameAs https://app.dimensions.ai/details/patent/WO-2013050529-A2
    91 schema:sdDatePublished 2019-04-18T10:10
    92 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    93 schema:sdPublisher Ndb9d9ccbdfb84f71b7645170c7fbe326
    94 sgo:license sg:explorer/license/
    95 sgo:sdDataset patents
    96 rdf:type sgo:Patent
    97 N16ce3146d44e47c3b00fcc6af25b154b rdf:first N7b5051f922484c7582add0c16da32735
    98 rdf:rest rdf:nil
    99 N41bb9b69ebad492981dcf100dd5e9ed1 rdf:first N50849385661443dd84fc80c4518ba297
    100 rdf:rest N16ce3146d44e47c3b00fcc6af25b154b
    101 N50849385661443dd84fc80c4518ba297 schema:name LUCIANI, Luisa
    102 rdf:type schema:Person
    103 N740a23bfbd864226bafbbcba8c83ff6a rdf:first Nf7d28788509646a39fd534c13438a0df
    104 rdf:rest N41bb9b69ebad492981dcf100dd5e9ed1
    105 N7b5051f922484c7582add0c16da32735 schema:name ROSENTHAL, NADIA
    106 rdf:type schema:Person
    107 Ndb9d9ccbdfb84f71b7645170c7fbe326 schema:name Springer Nature - SN SciGraph project
    108 rdf:type schema:Organization
    109 Nf7d28788509646a39fd534c13438a0df schema:name BILBAO CORTES, Daniel
    110 rdf:type schema:Person
    111 anzsrc-for:3053 schema:inDefinedTermSet anzsrc-for:
    112 rdf:type schema:DefinedTerm
    113 anzsrc-for:3103 schema:inDefinedTermSet anzsrc-for:
    114 rdf:type schema:DefinedTerm
    115 sg:pub.10.1007/s00109-004-0608-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028707088
    116 https://doi.org/10.1007/s00109-004-0608-2
    117 rdf:type schema:CreativeWork
    118 sg:pub.10.1007/s00415-007-1003-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1022968398
    119 https://doi.org/10.1007/s00415-007-1003-z
    120 rdf:type schema:CreativeWork
    121 sg:pub.10.1007/s00535-012-0668-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1000573532
    122 https://doi.org/10.1007/s00535-012-0668-y
    123 rdf:type schema:CreativeWork
    124 sg:pub.10.1007/s10165-006-0501-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030190312
    125 https://doi.org/10.1007/s10165-006-0501-7
    126 rdf:type schema:CreativeWork
    127 sg:pub.10.1007/s11095-005-4590-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041724590
    128 https://doi.org/10.1007/s11095-005-4590-3
    129 rdf:type schema:CreativeWork
    130 sg:pub.10.1007/s11096-008-9205-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030409713
    131 https://doi.org/10.1007/s11096-008-9205-8
    132 rdf:type schema:CreativeWork
    133 sg:pub.10.1023/a:1016486910719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041254126
    134 https://doi.org/10.1023/a:1016486910719
    135 rdf:type schema:CreativeWork
    136 sg:pub.10.1038/ni.1818 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018345956
    137 https://doi.org/10.1038/ni.1818
    138 rdf:type schema:CreativeWork
    139 sg:pub.10.1038/ni0901-816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027284442
    140 https://doi.org/10.1038/ni0901-816
    141 rdf:type schema:CreativeWork
    142 sg:pub.10.1038/ni1181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044334928
    143 https://doi.org/10.1038/ni1181
    144 rdf:type schema:CreativeWork
    145 sg:pub.10.1038/ni1375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026540507
    146 https://doi.org/10.1038/ni1375
    147 rdf:type schema:CreativeWork
    148 sg:pub.10.1038/ni1504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000494859
    149 https://doi.org/10.1038/ni1504
    150 rdf:type schema:CreativeWork
    151 sg:pub.10.1038/ni904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053106484
    152 https://doi.org/10.1038/ni904
    153 rdf:type schema:CreativeWork
    154 sg:pub.10.1038/ni909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032222092
    155 https://doi.org/10.1038/ni909
    156 rdf:type schema:CreativeWork
    157 sg:pub.10.1038/nm.1964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018401818
    158 https://doi.org/10.1038/nm.1964
    159 rdf:type schema:CreativeWork
    160 sg:pub.10.1038/nm.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003810856
    161 https://doi.org/10.1038/nm.2001
    162 rdf:type schema:CreativeWork
    163 sg:pub.10.1038/nm.2353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030246788
    164 https://doi.org/10.1038/nm.2353
    165 rdf:type schema:CreativeWork
    166 sg:pub.10.1038/nm0809-844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049583443
    167 https://doi.org/10.1038/nm0809-844
    168 rdf:type schema:CreativeWork
    169 sg:pub.10.1038/nm1564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028110690
    170 https://doi.org/10.1038/nm1564
    171 rdf:type schema:CreativeWork
    172 sg:pub.10.1038/nri2785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009921186
    173 https://doi.org/10.1038/nri2785
    174 rdf:type schema:CreativeWork
    175 sg:pub.10.1038/sj.gene.6363683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045483367
    176 https://doi.org/10.1038/sj.gene.6363683
    177 rdf:type schema:CreativeWork
    178 sg:pub.10.1038/sj.gt.3300947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030560074
    179 https://doi.org/10.1038/sj.gt.3300947
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1186/1479-5876-10-182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014010677
    182 https://doi.org/10.1186/1479-5876-10-182
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1186/1479-5876-11-266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042013879
    185 https://doi.org/10.1186/1479-5876-11-266
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1208/s12248-008-9065-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025571201
    188 https://doi.org/10.1208/s12248-008-9065-0
    189 rdf:type schema:CreativeWork
    190 https://doi.org/10.1002/cyto.a.20659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011769597
    191 rdf:type schema:CreativeWork
    192 https://doi.org/10.1002/eji.1830250411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001813212
    193 rdf:type schema:CreativeWork
    194 https://doi.org/10.1006/mcne.1994.1052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020787039
    195 rdf:type schema:CreativeWork
    196 https://doi.org/10.1016/0008-8749(88)90225-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053371718
    197 rdf:type schema:CreativeWork
    198 https://doi.org/10.1016/0026-0495(78)90267-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033275031
    199 rdf:type schema:CreativeWork
    200 https://doi.org/10.1016/j.cell.2010.02.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015811420
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.1016/j.intimp.2010.11.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017139999
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.1016/j.jaci.2005.10.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026476846
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.1016/j.jri.2010.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048103109
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.1016/j.molimm.2009.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035818869
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1016/j.nmd.2007.06.466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053273057
    211 rdf:type schema:CreativeWork
    212 https://doi.org/10.1016/s0091-6749(97)70006-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002231464
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1016/s1471-4906(00)01815-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027338906
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1046/j.1468-1331.2003.00638.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053106208
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1053/j.jvca.2015.05.198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003073387
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1055/s-2003-41137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057423521
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1073/pnas.0303792101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019561902
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1073/pnas.92.13.6190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017517603
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1073/pnas.95.26.15603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004157296
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1083/jcb.200105147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012924704
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1083/jcb.200108071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017578270
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1084/jem.20030686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030332792
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1111/j.1365-2222.2009.03301.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000268313
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1124/pr.109.002469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043685345
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1126/science.1079490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047445436
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1126/science.1106442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033734963
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1126/science.1201475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028801106
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1126/science.180605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062507737
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1126/science.332.6033.1020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062607053
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1136/mp.54.4.227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011602568
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1146/annurev.immunol.21.120601.141122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027044744
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1146/annurev.immunol.24.021605.090547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036861938
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1172/jci1486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053329241
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1182/blood-2003-01-0100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014015431
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1210/er.15.1.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064285636
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1210/er.21.3.292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064286137
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1523/jneurosci.23-20-07710.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075335935
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.2174/156652309788488569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037072466
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.2337/db06-0328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008504650
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.2337/diabetes.52.10.2483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051160498
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.2353/ajpath.2010.090759 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005780751
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.4049/jimmunol.181.10.6942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077805381
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.5021/ad.2010.22.4.397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041010573
    275 rdf:type schema:CreativeWork
    276 https://www.grid.ac/institutes/grid.4709.a schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...