Modulation Of Mirna In Diseases With Aberrant Angiogenesis


Ontology type: sgo:Patent     


Patent Info

DATE

2012-10-18T00:00

AUTHORS

TJWA MARC

ABSTRACT

The present application relates to the field of microRNAs, and more particular to the role of microRNAs in angiogenesis. It is demonstrated herein that modulation of specific microRNAs, such as miR-144, has therapeutic potential in diseases characterized by aberrant angiogenesis. This is particularly relevant in, for instance, tumour growth and metastasis, which are characterized by excessive angiogenesis and for which inhibition of miR-144 is a novel therapeutic strategy. On the other hand, diseases characterized by insufficient angiogenesis (e.g. associated with ischemia) may benefit from increasing miR-144 activity. More... »

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