Peptide Mimetic Ligands Of Polo-Like Kinase 1 Polo Box Domain And Methods Of Use


Ontology type: sgo:Patent     


Patent Info

DATE

2010-11-18T00:00

AUTHORS

BURKE, TERRENCE, R. , LIU, FA , LEE, KYUNG, S. , PARK, JUNG-EUN

ABSTRACT

Found in various eukaryotic organisms, polo-like kinases (collectively, Plks) are a conserved subfamily of Ser/Thr protein kinases that play critical roles in cell proliferation. Provided herein are compounds that specifically inhibit the activity of Plks, specifically Plkl. Further provided herein are methods for use of the compounds for the treatment of hyperprolif erative disorders, particularly cancer. Also provided are uses of the compounds for the preparation of a medicament. More... »

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