Preparation Of Isolated Agonist Anti-Edar Monoclonal Antibodies


Ontology type: sgo:Patent     


Patent Info

DATE

2010-10-07T00:00

AUTHORS

SCHNEIDER, PASCAL , DUNKEL, NATHALIE , DEMOTZ, Stéphane

ABSTRACT

The present invention concerns the preparation of substantially purified agonist anti- EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof. The invention further relates to isolated agonist anti- EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof as well as their use in the treatment of X-lmked hypohidrotic ectodermal dysplasia and tooth agenesis. The invention also relates to a pharmaceutical composition comprising said isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof and to a method of treating X-linked hypohidrotic ectodermal dysplasia and tooth agenesis. Finally, the present invention concerns a pharmaceutical kit comprising said isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof. More... »

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