Novel Engineered Microorganism Producing Homo-Succinic Acid And Method For Preparing Succinic Acid Using The Same


Ontology type: sgo:Patent     


Patent Info

DATE

2008-01-31T00:00

AUTHORS

LEE, SANG YUP , LIM, SUNG WON , SONG, HYOHAK

ABSTRACT

The present invention relates to a rumen bacterial mutant producing homo- succinic acid and a method for producing homo-succinic acid using the same, and more particularly to a rumen bacterial mutant producing succinic acid at a high concentration while producing little or no other organic acids in anaerobic conditions, which is obtained by disrupting a gene encoding lactate dehydrogenase (idhA), a gene encoding phosphotransacetylase (pta), and a gene encoding acetate kinase (ackA), without disrupting a gene encoding pyruvate formate lyase (pβ), as well as a method for producing succinic acid using the same. The inventive rumen bacterial mutant has the property of having a high growth rate and succinic acid productivity while producing little or no organic acids, as compared to the prior strains producing succinic acid. Thus, the inventive rumen bacterial mutant is useful to produce succinic acid for industrial use. More... »

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