Albumin-Binding Derivatives Of Therapeutic Peptides


Ontology type: sgo:Patent     


Patent Info

DATE

2005-09-29T00:00

AUTHORS

DOERWALD FLORENCIO ZARAGOZA , PESCHKE BERND

ABSTRACT

The present invention relates to a new drug delivery system, based on novel compounds with high affinity to plasma proteins (= affinity tags). These affinity tags can be linked to therapeutically active compounds and thereby enhance their half-life in plasma by reversible binding to plasma proteins.The present invention intends to provide a versatile delivery system for therapeutic agents, such as proteins, peptides, or small molecule drugs, by covalently binding these therapeutic agents to a plasma-protein ligand, capable of reversible binding to one or several plasma proteins. We have designed a novel linking strategy which enables the covalent binding of known, plasma-protein binding carboxylic acids to a broad variety of therapeutic peptides or proteins, or to any other type of compound, of which a prolonged periferal exposure at well-defined concentrations is required. This strategy consists in converting said plasma-protein binding carboxylic acid into a carboxylic acid mimetic, having a pKa between -5 and +7, in order to be ionized to a significant extent in plasma. Such a carboxylic acid mimetic could be, for instance, an N-acylsulfbnamide, which contains an additional functional group which enables covalent binding of the acid mimetic to a therapeutic agent. This linking strategy should not significantly disturb the structure of the plasma-protein binding acid, if a suitable acid mimetic has been chosen. The present invention álso relates to a compound of the general formula (II), wherein R1, G, Z, X, and Y are defined as described. The present invention also relates to pharmaceutical compositions comprising a compound according to the present invention and the use of compounds according to the present invention for preparing medicaments for treating disease. More... »

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3039", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "DOERWALD FLORENCIO ZARAGOZA", 
        "type": "Person"
      }, 
      {
        "name": "PESCHKE BERND", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1042/bj3120725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007491704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3120725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007491704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250050903", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013633156", 
          "https://doi.org/10.1007/s001250050903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250050903", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013633156", 
          "https://doi.org/10.1007/s001250050903"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005-09-29T00:00", 
    "description": "

The present invention relates to a new drug delivery system, based on novel compounds with high affinity to plasma proteins (= affinity tags). These affinity tags can be linked to therapeutically active compounds and thereby enhance their half-life in plasma by reversible binding to plasma proteins.The present invention intends to provide a versatile delivery system for therapeutic agents, such as proteins, peptides, or small molecule drugs, by covalently binding these therapeutic agents to a plasma-protein ligand, capable of reversible binding to one or several plasma proteins. We have designed a novel linking strategy which enables the covalent binding of known, plasma-protein binding carboxylic acids to a broad variety of therapeutic peptides or proteins, or to any other type of compound, of which a prolonged periferal exposure at well-defined concentrations is required. This strategy consists in converting said plasma-protein binding carboxylic acid into a carboxylic acid mimetic, having a pKa between -5 and +7, in order to be ionized to a significant extent in plasma. Such a carboxylic acid mimetic could be, for instance, an N-acylsulfbnamide, which contains an additional functional group which enables covalent binding of the acid mimetic to a therapeutic agent. This linking strategy should not significantly disturb the structure of the plasma-protein binding acid, if a suitable acid mimetic has been chosen. The present invention álso relates to a compound of the general formula (II), wherein R1, G, Z, X, and Y are defined as described. The present invention also relates to pharmaceutical compositions comprising a compound according to the present invention and the use of compounds according to the present invention for preparing medicaments for treating disease.

", "id": "sg:patent.WO-2005028516-A3", "keywords": [ "therapeutic peptide", "invention", "drug delivery system", "novel compound", "high affinity", "plasma protein", "affinity tag", "active compound", "half-life", "plasma", "reversible binding", "delivery system", "therapeutic agent", "protein", "peptide", "small molecule drug", "binding", "covalent binding", "plasma protein binding", "broad variety", "compound", "exposure", "well", "carboxylic acid", "PKA", "significant extent", "instance", "NS", "functional group", "acid", "general formula", "wherein", "pharmaceutical", "disease" ], "name": "ALBUMIN-BINDING DERIVATIVES OF THERAPEUTIC PEPTIDES", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.425956.9", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/WO-2005028516-A3" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:30", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_03489.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.WO-2005028516-A3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.WO-2005028516-A3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.WO-2005028516-A3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.WO-2005028516-A3'


 

This table displays all metadata directly associated to this object as RDF triples.

67 TRIPLES      15 PREDICATES      50 URIs      42 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.WO-2005028516-A3 schema:about anzsrc-for:3039
2 schema:author N860ea3eeca064144b2d2eecdce329484
3 schema:citation sg:pub.10.1007/s001250050903
4 https://doi.org/10.1042/bj3120725
5 schema:datePublished 2005-09-29T00:00
6 schema:description <p>The present invention relates to a new drug delivery system, based on novel compounds with high affinity to plasma proteins (= affinity tags). These affinity tags can be linked to therapeutically active compounds and thereby enhance their half-life in plasma by reversible binding to plasma proteins.The present invention intends to provide a versatile delivery system for therapeutic agents, such as proteins, peptides, or small molecule drugs, by covalently binding these therapeutic agents to a plasma-protein ligand, capable of reversible binding to one or several plasma proteins. We have designed a novel linking strategy which enables the covalent binding of known, plasma-protein binding carboxylic acids to a broad variety of therapeutic peptides or proteins, or to any other type of compound, of which a prolonged periferal exposure at well-defined concentrations is required. This strategy consists in converting said plasma-protein binding carboxylic acid into a carboxylic acid mimetic, having a pKa between -5 and +7, in order to be ionized to a significant extent in plasma. Such a carboxylic acid mimetic could be, for instance, an N-acylsulfbnamide, which contains an additional functional group which enables covalent binding of the acid mimetic to a therapeutic agent. This linking strategy should not significantly disturb the structure of the plasma-protein binding acid, if a suitable acid mimetic has been chosen. The present invention &#225;lso relates to a compound of the general formula (II), wherein R1, G, Z, X, and Y are defined as described. The present invention also relates to pharmaceutical compositions comprising a compound according to the present invention and the use of compounds according to the present invention for preparing medicaments for treating disease.</p>
7 schema:keywords NS
8 PKA
9 acid
10 active compound
11 affinity tag
12 binding
13 broad variety
14 carboxylic acid
15 compound
16 covalent binding
17 delivery system
18 disease
19 drug delivery system
20 exposure
21 functional group
22 general formula
23 half-life
24 high affinity
25 instance
26 invention
27 novel compound
28 peptide
29 pharmaceutical
30 plasma
31 plasma protein
32 plasma protein binding
33 protein
34 reversible binding
35 significant extent
36 small molecule drug
37 therapeutic agent
38 therapeutic peptide
39 well
40 wherein
41 schema:name ALBUMIN-BINDING DERIVATIVES OF THERAPEUTIC PEPTIDES
42 schema:recipient https://www.grid.ac/institutes/grid.425956.9
43 schema:sameAs https://app.dimensions.ai/details/patent/WO-2005028516-A3
44 schema:sdDatePublished 2019-04-18T10:30
45 schema:sdLicense https://scigraph.springernature.com/explorer/license/
46 schema:sdPublisher Nbc4a62fdc2574fb0abc3658744c7d342
47 sgo:license sg:explorer/license/
48 sgo:sdDataset patents
49 rdf:type sgo:Patent
50 N3005d0045a7f4ece9086bd37d8c71f46 schema:name DOERWALD FLORENCIO ZARAGOZA
51 rdf:type schema:Person
52 N860ea3eeca064144b2d2eecdce329484 rdf:first N3005d0045a7f4ece9086bd37d8c71f46
53 rdf:rest Nda35863d62a64264a0bc89a7b56ecc45
54 Na9032802585544018d49c2aabde767b9 schema:name PESCHKE BERND
55 rdf:type schema:Person
56 Nbc4a62fdc2574fb0abc3658744c7d342 schema:name Springer Nature - SN SciGraph project
57 rdf:type schema:Organization
58 Nda35863d62a64264a0bc89a7b56ecc45 rdf:first Na9032802585544018d49c2aabde767b9
59 rdf:rest rdf:nil
60 anzsrc-for:3039 schema:inDefinedTermSet anzsrc-for:
61 rdf:type schema:DefinedTerm
62 sg:pub.10.1007/s001250050903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013633156
63 https://doi.org/10.1007/s001250050903
64 rdf:type schema:CreativeWork
65 https://doi.org/10.1042/bj3120725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007491704
66 rdf:type schema:CreativeWork
67 https://www.grid.ac/institutes/grid.425956.9 schema:Organization
 




Preview window. Press ESC to close (or click here)


...