Atomic Structure Of The Catalytic Domain For Use In Designing And Identifying Inhibitors Of Zap-70 Kinase


Ontology type: sgo:Patent     


Patent Info

DATE

2004-04-08T00:00

AUTHORS

GEISER MARTIN , GEISSE SABINE , OSTERMEIER CHRISTIAN , RAMAGE PAUL , RAULF FRIEDRICH , ZENKE GERHARD

ABSTRACT

The present invention relates to the three dimensional structure of ZAP-70 protein tyrosine kinase and describes methods of making a crystal of ZAP-70 and purification of the catalytic domain of ZAP-70 for use in crystallisation. The invention also relates to the use of the three dimensional structure of the catalytic domain of ZAP-70 for identifying and designing ligands which inhibit the biological function of ZAP-70. More... »

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