Compositions Comprising Phospholipase C Inhibitors And Methods For Enhancing Paracellular Permeability Across Epithelial And Endothelial Barriers


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

THAKKER DHIREN R , WARD PETER D

ABSTRACT

Compositions and methods for enhancing paracellular permeability at an absorption site in a subject are disclosed. The method includes: (a) administering an effective amount of a phospholipase C inhibitor to a subject at a time in which enhanced paracellular permeability is desired; and (b) enhancing paracellular permaeability in the subject at the the absorption site through the administering of the effective amount of the phospholipase C inhibitor. The disclosed compositions and methods provide enhanced absorption of a hydrophilic drug in a subject. More... »

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