Aromatic Composition Consisting Of Hla Molecules


Ontology type: sgo:Patent     


Patent Info

DATE

2001-11-01T00:00

AUTHORS

ZIEGLER, ANDREAS , UCHANSKA-ZIEGLER, BARBARA , GOLZ-BERNER, KARIN , ZASTROW, LEONHARD

ABSTRACT

The invention relates to novel aromatic compositions consisting of HLA molecules, to which two different potential perfume carriers are assigned. The invention aims at developing novel aromatic compositions consisting of HLA molecules based on the selection of alleles of genes which are relevant from an olfactory viewpoint and subsequent processing thereof. According to the invention, the aromatic compositions are produced by selecting one allele amongst known class I HLA alleles, which differs in at least one characteristic from other alleles of HLA class I molecules and which is present in less than 5 % of individuals of the world population; the protein that is coded for by the selected allele undergoes assembly in the presence of β2-microglobulin (β2m); the formed HLA class I molecules are purified with the bonded peptides and fragmented with the protease, and the odor-active substances resulting from fragmentation are added as individual components or as a mixture to a cosmetic preparation. More... »

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