Transgenic Animal Expressing Non-Native Wild-Type And Familial Alzheimer'S Disease Mutant Presenilin 1 Protein On Native Presenilin 1 Null Background


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

ZHENG, HUI , QIAN, SU , VAN DER PLOEG, LEONARDUS, H., T. , WONG, PHILIP, C. , SISODIA, SANGRAM, S. , JIANG, PING

ABSTRACT

The present invention relates to a transgenic non-human animal embryo laking native presenilin (1) and a transgenic non-human animal having only a non-native presenilin (1). The transgenic animals and cells derived therefrom can be used in the study of the expression pattern, activity and modulators of presenilin (1), in the study of the role of presenilin (1) in Alzheimer's Disease and in the study of disorders of the central nervous system. More... »

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