Method and conjugate for treating h. pylori infection


Ontology type: sgo:Patent     


Patent Info

DATE

1998-09-17T00:00

AUTHORS

BRAGG RANDALL , IVERSON PATRICK L , SUMMERTON JAMES E , WELLER DWIGHT D

ABSTRACT

A method and conjugate for treating H. pylori infection in a subject are disclosed. The conjugate is composed of (a) a nuclease-resistant antisense oligomer effective to inhibit H. pylori infection in the subject by base-specific Watson-Crick binding to an H. pylori mRNA transcript, and (b) a transport moiety conjugated to the oligomer. The transport moiety is effective to facilitate uptake of the conjugate from the environment of the stomach into the cytoplasm of H. pylori cells by active transport or by pH-gradient transport across of the cell membrane of H. pylori. The conjugate is administered by oral route, preferably in a swellable polymer bolus designed to release the conjugate in sustained release. More... »

Related SciGraph Publications

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "BRAGG RANDALL", 
        "type": "Person"
      }, 
      {
        "name": "IVERSON PATRICK L", 
        "type": "Person"
      }, 
      {
        "name": "SUMMERTON JAMES E", 
        "type": "Person"
      }, 
      {
        "name": "WELLER DWIGHT D", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/nar/17.15.6129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011530894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/41483", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043803227", 
          "https://doi.org/10.1038/41483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/41483", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043803227", 
          "https://doi.org/10.1038/41483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jo00228a010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055974177"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1998-09-17T00:00", 
    "description": "

A method and conjugate for treating H. pylori infection in a subject are disclosed. The conjugate is composed of (a) a nuclease-resistant antisense oligomer effective to inhibit H. pylori infection in the subject by base-specific Watson-Crick binding to an H. pylori mRNA transcript, and (b) a transport moiety conjugated to the oligomer. The transport moiety is effective to facilitate uptake of the conjugate from the environment of the stomach into the cytoplasm of H. pylori cells by active transport or by pH-gradient transport across of the cell membrane of H. pylori. The conjugate is administered by oral route, preferably in a swellable polymer bolus designed to release the conjugate in sustained release.

", "id": "sg:patent.WO-1998032467-A3", "keywords": [ "method", "conjugate", "H. pylorus infection", "antisense oligomers", "binding", "mRNA transcript", "transport", "oligomers", "uptake", "environment", "stomach", "cytoplasm", "H. pylorus", "Active Biological Transport", "Cell Membrane", "oral route", "polymer", "release", "sustained release" ], "name": "Method and conjugate for treating h. pylori infection", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.410442.7", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/WO-1998032467-A3" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:30", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_03437.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.WO-1998032467-A3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.WO-1998032467-A3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.WO-1998032467-A3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.WO-1998032467-A3'


 

This table displays all metadata directly associated to this object as RDF triples.

63 TRIPLES      15 PREDICATES      36 URIs      27 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.WO-1998032467-A3 schema:about anzsrc-for:3114
2 schema:author N437dcbaafd70450e89403db34d0a1899
3 schema:citation sg:pub.10.1038/41483
4 https://doi.org/10.1021/jo00228a010
5 https://doi.org/10.1093/nar/17.15.6129
6 schema:datePublished 1998-09-17T00:00
7 schema:description <p>A method and conjugate for treating H. pylori infection in a subject are disclosed. The conjugate is composed of (a) a nuclease-resistant antisense oligomer effective to inhibit H. pylori infection in the subject by base-specific Watson-Crick binding to an H. pylori mRNA transcript, and (b) a transport moiety conjugated to the oligomer. The transport moiety is effective to facilitate uptake of the conjugate from the environment of the stomach into the cytoplasm of H. pylori cells by active transport or by pH-gradient transport across of the cell membrane of H. pylori. The conjugate is administered by oral route, preferably in a swellable polymer bolus designed to release the conjugate in sustained release.</p>
8 schema:keywords Active Biological Transport
9 Cell Membrane
10 H. pylorus
11 H. pylorus infection
12 antisense oligomers
13 binding
14 conjugate
15 cytoplasm
16 environment
17 mRNA transcript
18 method
19 oligomers
20 oral route
21 polymer
22 release
23 stomach
24 sustained release
25 transport
26 uptake
27 schema:name Method and conjugate for treating h. pylori infection
28 schema:recipient https://www.grid.ac/institutes/grid.410442.7
29 schema:sameAs https://app.dimensions.ai/details/patent/WO-1998032467-A3
30 schema:sdDatePublished 2019-04-18T10:30
31 schema:sdLicense https://scigraph.springernature.com/explorer/license/
32 schema:sdPublisher Nf82fb30e9afa4ef2a7f9bd16aad98dac
33 sgo:license sg:explorer/license/
34 sgo:sdDataset patents
35 rdf:type sgo:Patent
36 N02fe281fdef845e8aacc7044bf6caa9b schema:name SUMMERTON JAMES E
37 rdf:type schema:Person
38 N2ea804c9a2294ca1aba7af4e3b030865 schema:name IVERSON PATRICK L
39 rdf:type schema:Person
40 N424f96db0a544a91b34c41c62f5c0c46 rdf:first N02fe281fdef845e8aacc7044bf6caa9b
41 rdf:rest Na205bbeffb8b4a97aabd7c72b883c58e
42 N437dcbaafd70450e89403db34d0a1899 rdf:first N5cd7a57a53644357aed29202cb548426
43 rdf:rest Na5664442c0d443eb9d7bb7474598101e
44 N5cd7a57a53644357aed29202cb548426 schema:name BRAGG RANDALL
45 rdf:type schema:Person
46 Na205bbeffb8b4a97aabd7c72b883c58e rdf:first Nd44b63d7d2544e2f8de4a27e86f8555a
47 rdf:rest rdf:nil
48 Na5664442c0d443eb9d7bb7474598101e rdf:first N2ea804c9a2294ca1aba7af4e3b030865
49 rdf:rest N424f96db0a544a91b34c41c62f5c0c46
50 Nd44b63d7d2544e2f8de4a27e86f8555a schema:name WELLER DWIGHT D
51 rdf:type schema:Person
52 Nf82fb30e9afa4ef2a7f9bd16aad98dac schema:name Springer Nature - SN SciGraph project
53 rdf:type schema:Organization
54 anzsrc-for:3114 schema:inDefinedTermSet anzsrc-for:
55 rdf:type schema:DefinedTerm
56 sg:pub.10.1038/41483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043803227
57 https://doi.org/10.1038/41483
58 rdf:type schema:CreativeWork
59 https://doi.org/10.1021/jo00228a010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055974177
60 rdf:type schema:CreativeWork
61 https://doi.org/10.1093/nar/17.15.6129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011530894
62 rdf:type schema:CreativeWork
63 https://www.grid.ac/institutes/grid.410442.7 schema:Organization
 




Preview window. Press ESC to close (or click here)


...