Chimeric Dna-Rna Catalytic Sequences


Ontology type: sgo:Patent     


Patent Info

DATE

1991-03-21T00:00

AUTHORS

ROSSI, JOHN, J. , CHANG, PAIROJ , KAPLAN, BRUCE, E.

ABSTRACT

This invention provides chimeric DNA/RNA catalytic molecules useful to cleave RNA sequences. The invention specifically provides two different chimeric DNA-RNA-DNA-RNA-DNA catalytic molecules which are targeted to cleave HIV-1 RNA sequences. These chimeric molecules include DNA sequences which flank a catalytic RNA center. Interaction with the HIV-1 substrate RNAs is achieved by Watson-Crick base pairing of the DNA flanking sequences with HIV-1 RNA. The catalytic ribonucleotide center cleaves the phosphodiester bond of the substrate HIV-1 RNA at the expected location. More... »

Related SciGraph Publications

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2620", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "ROSSI, JOHN, J.", 
        "type": "Person"
      }, 
      {
        "name": "CHANG, PAIROJ", 
        "type": "Person"
      }, 
      {
        "name": "KAPLAN, BRUCE, E.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/344565a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011248369", 
          "https://doi.org/10.1038/344565a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.86.23.9139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029964827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2107573", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062522378"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1991-03-21T00:00", 
    "description": "

This invention provides chimeric DNA/RNA catalytic molecules useful to cleave RNA sequences. The invention specifically provides two different chimeric DNA-RNA-DNA-RNA-DNA catalytic molecules which are targeted to cleave HIV-1 RNA sequences. These chimeric molecules include DNA sequences which flank a catalytic RNA center. Interaction with the HIV-1 substrate RNAs is achieved by Watson-Crick base pairing of the DNA flanking sequences with HIV-1 RNA. The catalytic ribonucleotide center cleaves the phosphodiester bond of the substrate HIV-1 RNA at the expected location.

", "id": "sg:patent.WO-1991003162-A1", "keywords": [ "sequence", "invention", "molecule", "Base Sequence", "HIV-1 RNA", "chimeric molecule", "flank", "Catalytic RNA", "HIV", "substrate RNA", "Base Pairing", "flanking sequence", "ribonucleotides", "phosphodiester bond", "substrate", "location" ], "name": "CHIMERIC DNA-RNA CATALYTIC SEQUENCES", "sameAs": [ "https://app.dimensions.ai/details/patent/WO-1991003162-A1" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:30", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_03410.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.WO-1991003162-A1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.WO-1991003162-A1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.WO-1991003162-A1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.WO-1991003162-A1'


 

This table displays all metadata directly associated to this object as RDF triples.

54 TRIPLES      14 PREDICATES      32 URIs      24 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.WO-1991003162-A1 schema:about anzsrc-for:2620
2 schema:author Neefddd199c1e4078a26a0f2d18b9551a
3 schema:citation sg:pub.10.1038/344565a0
4 https://doi.org/10.1073/pnas.86.23.9139
5 https://doi.org/10.1126/science.2107573
6 schema:datePublished 1991-03-21T00:00
7 schema:description <p>This invention provides chimeric DNA/RNA catalytic molecules useful to cleave RNA sequences. The invention specifically provides two different chimeric DNA-RNA-DNA-RNA-DNA catalytic molecules which are targeted to cleave HIV-1 RNA sequences. These chimeric molecules include DNA sequences which flank a catalytic RNA center. Interaction with the HIV-1 substrate RNAs is achieved by Watson-Crick base pairing of the DNA flanking sequences with HIV-1 RNA. The catalytic ribonucleotide center cleaves the phosphodiester bond of the substrate HIV-1 RNA at the expected location.</p>
8 schema:keywords Base Pairing
9 Base Sequence
10 Catalytic RNA
11 HIV
12 HIV-1 RNA
13 chimeric molecule
14 flank
15 flanking sequence
16 invention
17 location
18 molecule
19 phosphodiester bond
20 ribonucleotides
21 sequence
22 substrate
23 substrate RNA
24 schema:name CHIMERIC DNA-RNA CATALYTIC SEQUENCES
25 schema:sameAs https://app.dimensions.ai/details/patent/WO-1991003162-A1
26 schema:sdDatePublished 2019-04-18T10:30
27 schema:sdLicense https://scigraph.springernature.com/explorer/license/
28 schema:sdPublisher N11dc16ebe8514d22b01cdc00e8b23ba5
29 sgo:license sg:explorer/license/
30 sgo:sdDataset patents
31 rdf:type sgo:Patent
32 N089fbdd4bac84f23a813070cb11dfe31 rdf:first N7d1f2ee0c8724dafb053f431d7874acf
33 rdf:rest rdf:nil
34 N11dc16ebe8514d22b01cdc00e8b23ba5 schema:name Springer Nature - SN SciGraph project
35 rdf:type schema:Organization
36 N1912a614caa1465b8e769d718cab31bc schema:name CHANG, PAIROJ
37 rdf:type schema:Person
38 N2712b53be536412592bd4b0a1b7a079a schema:name ROSSI, JOHN, J.
39 rdf:type schema:Person
40 N32f9a53bb9784ac5873f91ed163ccd7e rdf:first N1912a614caa1465b8e769d718cab31bc
41 rdf:rest N089fbdd4bac84f23a813070cb11dfe31
42 N7d1f2ee0c8724dafb053f431d7874acf schema:name KAPLAN, BRUCE, E.
43 rdf:type schema:Person
44 Neefddd199c1e4078a26a0f2d18b9551a rdf:first N2712b53be536412592bd4b0a1b7a079a
45 rdf:rest N32f9a53bb9784ac5873f91ed163ccd7e
46 anzsrc-for:2620 schema:inDefinedTermSet anzsrc-for:
47 rdf:type schema:DefinedTerm
48 sg:pub.10.1038/344565a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011248369
49 https://doi.org/10.1038/344565a0
50 rdf:type schema:CreativeWork
51 https://doi.org/10.1073/pnas.86.23.9139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029964827
52 rdf:type schema:CreativeWork
53 https://doi.org/10.1126/science.2107573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062522378
54 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...