Delivery of negatively charged proteins using cationic lipids


Ontology type: sgo:Patent     


Patent Info

DATE

2018-06-19T00:00

AUTHORS

LIU DAVID R , THOMPSON DAVID B , ZURIS JOHN ANTHONY

ABSTRACT

Compositions, methods, strategies, kits, and systems for the delivery of negatively charged proteins, protein complexes, and fusion proteins, using cationic polymers or lipids are provided. Delivery of proteins into cells can be effected in vivo, ex vivo, or in vitro. Proteins that can be delivered using the compositions, methods, strategies, kits, and systems provided herein include, without limitation, enzymes, transcription factors, genome editing proteins, Cas9 proteins, TALEs, TALENs, nucleases, binding proteins (e.g., ligands, receptors, antibodies, antibody fragments; nucleic acid binding proteins, etc.), structural proteins, and therapeutic proteins (e.g., tumor suppressor proteins, therapeutic enzymes, growth factors, growth factor receptors, transcription factors, proteases, etc.), as well as variants and fusions of such proteins. More... »

Related SciGraph Publications

  • 1994-03. Expression of a dominant negative retinoic acid receptor γ in Xenopus embryos leads to partial resistance to retinoic acid in DEVELOPMENT GENES AND EVOLUTION
  • 2016-04-20. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage in NATURE
  • 2017-02-13. Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions in NATURE BIOTECHNOLOGY
  • 2017-07-25. Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system in NATURE COMMUNICATIONS
  • 2013-02-10. TALENs and ZFNs are associated with different mutation signatures in NATURE METHODS
  • 2012-04-24. Conditional Gene Expression in the Mouse Inner Ear Using Cre-loxP in JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
  • 2016-10-31. Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells in NATURE METHODS
  • 2017-08-19. Highly efficient and precise base editing in discarded human tripronuclear embryos in PROTEIN & CELL
  • 2014-12-16. GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases in NATURE BIOTECHNOLOGY
  • 2015-04-01. In vivo genome editing using Staphylococcus aureus Cas9 in NATURE
  • 2013-02-10. Robust, synergistic regulation of human gene expression using TALE activators in NATURE METHODS
  • 2012-01-05. A transcription activator-like effector toolbox for genome engineering in NATURE PROTOCOLS
  • 2010-12-22. A TALE nuclease architecture for efficient genome editing in NATURE BIOTECHNOLOGY
  • 2014-07-27. Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease in NATURE
  • 2015-03-02. Highly efficient Cas9-mediated transcriptional programming in NATURE METHODS
  • 2015-06-22. Engineered CRISPR-Cas9 nucleases with altered PAM specificities in NATURE
  • 2015-02-05. Therapeutic genome editing: prospects and challenges in NATURE MEDICINE
  • 2016-10-10. Targeted AID-mediated mutagenesis (TAM) enables efficient genomic diversification in mammalian cells in NATURE METHODS
  • 2017-02-27. Highly efficient RNA-guided base editing in mouse embryos in NATURE BIOTECHNOLOGY
  • 2008. Design and Testing of Zinc Finger Nucleases for Use in Mammalian Cells in CHROMOSOMAL MUTAGENESIS
  • 2017-02-27. Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion in NATURE BIOTECHNOLOGY
  • 2015-04-01. Long-term and efficient expression of human β-globin gene in a hematopoietic cell line using a new site-specific integrating non-viral system in GENE THERAPY
  • 2012-02-15. RNA-guided genetic silencing systems in bacteria and archaea in NATURE
  • 1999-02. Disentangling the perturbational effects of amino acid substitutions in the DNA-binding domain of p53 in HUMAN GENETICS
  • 2011-11-08. Evaluation of genomic high-throughput sequencing data generated on Illumina HiSeq and Genome Analyzer systems in GENOME BIOLOGY
  • 2014-01-29. DNA interrogation by the CRISPR RNA-guided endonuclease Cas9 in NATURE
  • 2011-03-30. CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III in NATURE
  • 2014-03-14. Homologous recombination in human embryonic stem cells using CRISPR/Cas9 nickase and a long DNA donor template in PROTEIN & CELL
  • 2012-09-23. In vivo genome editing using a high-efficiency TALEN system in NATURE
  • 2012-11-21. TALENs: a widely applicable technology for targeted genome editing in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2014-09-28. Programmable RNA recognition and cleavage by CRISPR/Cas9 in NATURE
  • 2015-01-30. DNA methylation age of blood predicts all-cause mortality in later life in GENOME BIOLOGY
  • 2005-04-03. Highly efficient endogenous human gene correction using designed zinc-finger nucleases in NATURE
  • 2013-06-23. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells in NATURE BIOTECHNOLOGY
  • 2014-02-16. DNA-guided DNA interference by a prokaryotic Argonaute in NATURE
  • 2013-01-29. RNA-guided editing of bacterial genomes using CRISPR-Cas systems in NATURE BIOTECHNOLOGY
  • 2010-01-10. APOBEC3 proteins mediate the clearance of foreign DNA from human cells in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2013-01-29. Efficient genome editing in zebrafish using a CRISPR-Cas system in NATURE BIOTECHNOLOGY
  • 2013-01-29. Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease in NATURE BIOTECHNOLOGY
  • 2011-08-07. Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection in NATURE METHODS
  • 2013-10-24. Genome engineering using the CRISPR-Cas9 system in NATURE PROTOCOLS
  • 2015-03-23. Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining in NATURE BIOTECHNOLOGY
  • 2015-03-24. Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells in NATURE BIOTECHNOLOGY
  • 2011-08-01. Targeted gene disruption in somatic zebrafish cells using engineered TALENs in NATURE BIOTECHNOLOGY
  • 2016-02-22. Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity in NATURE BIOTECHNOLOGY
  • 2010-10-24. Recombinase technology: applications and possibilities in PLANT CELL REPORTS
  • 2011-08-01. Heritable gene targeting in zebrafish using customized TALENs in NATURE BIOTECHNOLOGY
  • 2001-12-01. A peptide carrier for the delivery of biologically active proteins into mammalian cells in NATURE BIOTECHNOLOGY
  • 2011-01-01. Targeted integration in rat and mouse embryos with zinc-finger nucleases in NATURE BIOTECHNOLOGY
  • 2013-06-23. Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape in NATURE BIOTECHNOLOGY
  • 2013-09-27. Cas9 as a versatile tool for engineering biology in NATURE METHODS
  • 2003-05. Drug discovery with engineered zinc-finger proteins in NATURE REVIEWS DRUG DISCOVERY
  • 2014-07-08. First CRISPR-Cas patent opens race to stake out intellectual property in NATURE BIOTECHNOLOGY
  • 2014-03-30. Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype in NATURE BIOTECHNOLOGY
  • 2013-02-17. A library of TAL effector nucleases spanning the human genome in NATURE BIOTECHNOLOGY
  • 2007-10-28. Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery in NATURE BIOTECHNOLOGY
  • 2017-03-27. Targeted base editing in rice and tomato using a CRISPR-Cas9 cytidine deaminase fusion in NATURE BIOTECHNOLOGY
  • 2014-04-20. Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells in NATURE BIOTECHNOLOGY
  • 2014-01-26. Improving CRISPR-Cas nuclease specificity using truncated guide RNAs in NATURE BIOTECHNOLOGY
  • 2015-04-06. Small molecule–triggered Cas9 protein with improved genome-editing specificity in NATURE CHEMICAL BIOLOGY
  • 2011-12-01. Safe harbours for the integration of new DNA in the human genome in NATURE REVIEWS CANCER
  • 2012-09-10. RNA-mediated programmable DNA cleavage in NATURE BIOTECHNOLOGY
  • 1998-02. Improving protein therapeutics with sustained-release formulations in NATURE BIOTECHNOLOGY
  • 2014-09-05. The evolutionary journey of Argonaute proteins in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2011-04-03. Structural basis for CRISPR RNA-guided DNA recognition by Cascade in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2008-08. Single-strand break repair and genetic disease in NATURE REVIEWS GENETICS
  • 2008. Chromosomal Mutagenesis in NONE
  • 2014-07-31. The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas in GENOME BIOLOGY
  • 2013-08-01. CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering in NATURE BIOTECHNOLOGY
  • 2013-08-11. High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity in NATURE BIOTECHNOLOGY
  • 2015-11-02. Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition in NATURE BIOTECHNOLOGY
  • 2001-11. Alteration of Cre recombinase site specificity by substrate-linked protein evolution in NATURE BIOTECHNOLOGY
  • 2008-04-27. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics in NATURE BIOTECHNOLOGY
  • 2016-04-20. Gene-editing hack yields pinpoint precision in NATURE
  • 2004-02-08. Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis in NATURE MEDICINE
  • 2008-05-25. Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases in NATURE BIOTECHNOLOGY
  • 2017-04-10. Genome-wide target specificities of CRISPR RNA-guided programmable deaminases in NATURE BIOTECHNOLOGY
  • 2012-10-23. Biological and Biomedical Applications of Engineered Nucleases in MOLECULAR BIOTECHNOLOGY
  • 2014-10-30. Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo in NATURE BIOTECHNOLOGY
  • 2014-04-25. Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification in NATURE BIOTECHNOLOGY
  • 2014-04-25. Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing in NATURE BIOTECHNOLOGY
  • 2008-09-11. Progress and prospects: Zinc-finger nucleases as gene therapy agents in GENE THERAPY
  • 2009-05-15. Site-Specific Recombinases for Manipulation of the Mouse Genome in TRANSGENESIS TECHNIQUES
  • 2009. Transgenesis Techniques, Principles and Protocols in NONE
  • 2009-10. Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes in NATURE
  • 2013-07-25. CRISPR RNA–guided activation of endogenous human genes in NATURE METHODS
  • 2014-03-22. Fidelity of end joining in mammalian episomes and the impact of Metnase on joint processing in BMC MOLECULAR AND CELL BIOLOGY
  • 2017-06-06. Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery in NATURE COMMUNICATIONS
  • 2016-01-20. Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA in NATURE BIOTECHNOLOGY
  • 2008-06-29. Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases in NATURE BIOTECHNOLOGY
  • 2014-05-18. Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease in NATURE BIOTECHNOLOGY
  • 2008. Gene Targeting in Drosophila and Caenorhabditis elegans With Zinc-Finger Nucleases in CHROMOSOMAL MUTAGENESIS
  • 2016-05-02. DNA-guided genome editing using the Natronobacterium gregoryi Argonaute in NATURE BIOTECHNOLOGY
  • 2016-01-06. High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects in NATURE
  • 2013-10-17. CRISPR interference (CRISPRi) for sequence-specific control of gene expression in NATURE PROTOCOLS
  • 2011-05-13. ZFN-Site searches genomes for zinc finger nuclease target sites and off-target sites in BMC BIOINFORMATICS
  • 2011-01-19. Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription in NATURE BIOTECHNOLOGY
  • 2007-07-01. An improved zinc-finger nuclease architecture for highly specific genome editing in NATURE BIOTECHNOLOGY
  • 2008-05-25. Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases in NATURE BIOTECHNOLOGY
  • 2008-02-20. Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G in NATURE
  • 2013-07-25. RNA-guided gene activation by CRISPR-Cas9–based transcription factors in NATURE METHODS
  • 2013-09-29. Orthogonal Cas9 proteins for RNA-guided gene regulation and editing in NATURE METHODS
  • 2017-06-05. CRISPR-STOP: gene silencing through base-editing-induced nonsense mutations in NATURE METHODS
  • 2010-09. Genome editing with engineered zinc finger nucleases in NATURE REVIEWS GENETICS
  • 2014-03-02. CRISPR-Cas systems for editing, regulating and targeting genomes in NATURE BIOTECHNOLOGY
  • 2013-07-21. DNA targeting specificity of RNA-guided Cas9 nucleases in NATURE BIOTECHNOLOGY
  • 2010-01-17. Rational design of cationic lipids for siRNA delivery in NATURE BIOTECHNOLOGY
  • 2015-02-02. A split-Cas9 architecture for inducible genome editing and transcription modulation in NATURE BIOTECHNOLOGY
  • 2011-02-07. TALEs of genome targeting in NATURE BIOTECHNOLOGY
  • 2013-08-14. Signatures of mutational processes in human cancer in NATURE
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "name": "LIU DAVID R", 
            "type": "Person"
          }, 
          {
            "name": "THOMPSON DAVID B", 
            "type": "Person"
          }, 
          {
            "name": "ZURIS JOHN ANTHONY", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature13769", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009875984", 
              "https://doi.org/10.1038/nature13769"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026122095", 
              "https://doi.org/10.1038/nbt1353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2889", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043519930", 
              "https://doi.org/10.1038/nbt.2889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1670", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043918422", 
              "https://doi.org/10.1038/nmeth.1670"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2675", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041659759", 
              "https://doi.org/10.1038/nbt.2675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0714-599", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049485528", 
              "https://doi.org/10.1038/nbt0714-599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2517", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017042091", 
              "https://doi.org/10.1038/nbt.2517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-59745-232-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011938717", 
              "https://doi.org/10.1007/978-1-59745-232-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12971", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052410148", 
              "https://doi.org/10.1038/nature12971"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14299", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019168198", 
              "https://doi.org/10.1038/nature14299"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature.2016.19773", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056448921", 
              "https://doi.org/10.1038/nature.2016.19773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2013.143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016534425", 
              "https://doi.org/10.1038/nprot.2013.143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10162-012-0324-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019406988", 
              "https://doi.org/10.1007/s10162-012-0324-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040117781", 
              "https://doi.org/10.1038/nature03556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2508", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019888616", 
              "https://doi.org/10.1038/nbt.2508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms15790", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085880702", 
              "https://doi.org/10.1038/ncomms15790"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio.1793", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042535273", 
              "https://doi.org/10.1038/nchembio.1793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2013.132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009361018", 
              "https://doi.org/10.1038/nprot.2013.132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004390050904", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035082076", 
              "https://doi.org/10.1007/s004390050904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/gt.2015.30", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005185460", 
              "https://doi.org/10.1038/gt.2015.30"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2908", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012868720", 
              "https://doi.org/10.1038/nbt.2908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1934", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010658010", 
              "https://doi.org/10.1038/nbt.1934"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06638", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015857224", 
              "https://doi.org/10.1038/nature06638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021849416", 
              "https://doi.org/10.1038/nbt.3117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2357", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014043446", 
              "https://doi.org/10.1038/nbt.2357"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10886", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053669571", 
              "https://doi.org/10.1038/nature10886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3852", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084753472", 
              "https://doi.org/10.1038/nbt.3852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-017-00175-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090780642", 
              "https://doi.org/10.1038/s41467-017-00175-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2842", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018939216", 
              "https://doi.org/10.1038/nrg2842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2879", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010082311", 
              "https://doi.org/10.1038/nsmb.2879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2011-12-11-r112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027516867", 
              "https://doi.org/10.1186/gb-2011-12-11-r112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1201-1173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033003564", 
              "https://doi.org/10.1038/nbt1201-1173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-59745-232-8_5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043561019", 
              "https://doi.org/10.1007/978-1-59745-232-8_5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3793", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052797737", 
              "https://doi.org/10.1038/nm.3793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050004918", 
              "https://doi.org/10.1038/nature12477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1602", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051671503", 
              "https://doi.org/10.1038/nbt.1602"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050461034", 
              "https://doi.org/10.1038/nrm3486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature16526", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010800066", 
              "https://doi.org/10.1038/nature16526"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.4327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085864346", 
              "https://doi.org/10.1038/nmeth.4327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1731", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030230970", 
              "https://doi.org/10.1038/nbt.1731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/gt.2008.145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045636817", 
              "https://doi.org/10.1038/gt.2008.145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13238-014-0032-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051855442", 
              "https://doi.org/10.1007/s13238-014-0032-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2681", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028304735", 
              "https://doi.org/10.1038/nmeth.2681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11537", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021191816", 
              "https://doi.org/10.1038/nature11537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1775", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031104364", 
              "https://doi.org/10.1038/nbt.1775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0298-153", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019139570", 
              "https://doi.org/10.1038/nbt0298-153"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2199-15-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018784555", 
              "https://doi.org/10.1186/1471-2199-15-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14592", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047292250", 
              "https://doi.org/10.1038/nature14592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.4027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038829252", 
              "https://doi.org/10.1038/nmeth.4027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.3312", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008897838", 
              "https://doi.org/10.1038/nmeth.3312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2649", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008703730", 
              "https://doi.org/10.1038/nmeth.2649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3833", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084128666", 
              "https://doi.org/10.1038/nbt.3833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034330725", 
              "https://doi.org/10.1038/nbt.3149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-59745-232-8_4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040102050", 
              "https://doi.org/10.1007/978-1-59745-232-8_4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-12-152", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031107821", 
              "https://doi.org/10.1186/1471-2105-12-152"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037342101", 
              "https://doi.org/10.1038/nature13011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3467", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020093829", 
              "https://doi.org/10.1038/nbt.3467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1939", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010610351", 
              "https://doi.org/10.1038/nbt.1939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00299-010-0938-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044696716", 
              "https://doi.org/10.1007/s00299-010-0938-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2598", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049500416", 
              "https://doi.org/10.1038/nmeth.2598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1755", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016004947", 
              "https://doi.org/10.1038/nbt.1755"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2673", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007302590", 
              "https://doi.org/10.1038/nbt.2673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3816", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084128652", 
              "https://doi.org/10.1038/nbt.3816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-60327-019-9_16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040082301", 
              "https://doi.org/10.1007/978-1-60327-019-9_16"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm996", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040467981", 
              "https://doi.org/10.1038/nm996"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1402", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029302550", 
              "https://doi.org/10.1038/nbt1402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1087", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040287926", 
              "https://doi.org/10.1038/nrd1087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2507", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041881936", 
              "https://doi.org/10.1038/nbt.2507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00360521", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038349147", 
              "https://doi.org/10.1007/bf00360521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.4038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030846996", 
              "https://doi.org/10.1038/nmeth.4038"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2380", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041270694", 
              "https://doi.org/10.1038/nrg2380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1409", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045837461", 
              "https://doi.org/10.1038/nbt1409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052351170", 
              "https://doi.org/10.1038/nrc3179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2647", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012543463", 
              "https://doi.org/10.1038/nbt.2647"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2612", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003176820", 
              "https://doi.org/10.1038/nbt.2612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2623", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009511624", 
              "https://doi.org/10.1038/nbt.2623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12033-012-9613-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031558495", 
              "https://doi.org/10.1007/s12033-012-9613-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1398", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032856466", 
              "https://doi.org/10.1038/nbt1398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13579", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036390967", 
              "https://doi.org/10.1038/nature13579"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3190", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017538548", 
              "https://doi.org/10.1038/nbt.3190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1101-1047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023451333", 
              "https://doi.org/10.1038/nbt1101-1047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053226125", 
              "https://doi.org/10.1038/nbt.2909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08434", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042379011", 
              "https://doi.org/10.1038/nature08434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3481", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004939292", 
              "https://doi.org/10.1038/nbt.3481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083803971", 
              "https://doi.org/10.1038/nbt.3803"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3547", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047211077", 
              "https://doi.org/10.1038/nbt.3547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2011.431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020679703", 
              "https://doi.org/10.1038/nprot.2011.431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2366", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040994508", 
              "https://doi.org/10.1038/nmeth.2366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2364", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015862962", 
              "https://doi.org/10.1038/nmeth.2364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2501", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024988605", 
              "https://doi.org/10.1038/nbt.2501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-015-0584-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024223648", 
              "https://doi.org/10.1186/s13059-015-0584-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052861805", 
              "https://doi.org/10.1038/nbt.3404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2842", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038520013", 
              "https://doi.org/10.1038/nbt.2842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011531387", 
              "https://doi.org/10.1038/nbt.2884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011829375", 
              "https://doi.org/10.1038/nsmb.2019"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017697957", 
              "https://doi.org/10.1038/nbt.3081"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2600", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024354143", 
              "https://doi.org/10.1038/nmeth.2600"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13238-017-0458-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091243310", 
              "https://doi.org/10.1007/s13238-017-0458-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09886", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030591890", 
              "https://doi.org/10.1038/nature09886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1410", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048577624", 
              "https://doi.org/10.1038/nbt1410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2916", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043348902", 
              "https://doi.org/10.1038/nbt.2916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1767", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022298591", 
              "https://doi.org/10.1038/nbt.1767"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-60327-019-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045514102", 
              "https://doi.org/10.1007/978-1-60327-019-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature17946", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009172001", 
              "https://doi.org/10.1038/nature17946"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3811", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084128647", 
              "https://doi.org/10.1038/nbt.3811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002154526", 
              "https://doi.org/10.1038/nbt1319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-014-0417-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025106002", 
              "https://doi.org/10.1186/s13059-014-0417-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008895789", 
              "https://doi.org/10.1038/nbt.3198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.1744", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002558962", 
              "https://doi.org/10.1038/nsmb.1744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2808", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048637524", 
              "https://doi.org/10.1038/nbt.2808"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-06-19T00:00", 
        "description": "

    Compositions, methods, strategies, kits, and systems for the delivery of negatively charged proteins, protein complexes, and fusion proteins, using cationic polymers or lipids are provided. Delivery of proteins into cells can be effected in vivo, ex vivo, or in vitro. Proteins that can be delivered using the compositions, methods, strategies, kits, and systems provided herein include, without limitation, enzymes, transcription factors, genome editing proteins, Cas9 proteins, TALEs, TALENs, nucleases, binding proteins (e.g., ligands, receptors, antibodies, antibody fragments; nucleic acid binding proteins, etc.), structural proteins, and therapeutic proteins (e.g., tumor suppressor proteins, therapeutic enzymes, growth factors, growth factor receptors, transcription factors, proteases, etc.), as well as variants and fusions of such proteins.

    ", "endDate": "2035-11-21", "id": "sg:patent.US-9999671-B2", "name": "Delivery of negatively charged proteins using cationic lipids", "recipient": [ { "id": "http://www.grid.ac/institutes/grid.38142.3c", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-9999671-B2" ], "sdDataset": "patents", "sdDatePublished": "2022-09-02T16:21", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/patent/patent_33.jsonl", "type": "Patent" } ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-9999671-B2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-9999671-B2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-9999671-B2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-9999671-B2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    474 TRIPLES      15 PREDICATES      126 URIs      9 LITERALS      2 BLANK NODES

    Subject Predicate Object
    1 sg:patent.US-9999671-B2 schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author Nd1bb571c165a456ea547072ec17f62e8
    4 schema:citation sg:pub.10.1007/978-1-59745-232-8
    5 sg:pub.10.1007/978-1-59745-232-8_4
    6 sg:pub.10.1007/978-1-59745-232-8_5
    7 sg:pub.10.1007/978-1-60327-019-9
    8 sg:pub.10.1007/978-1-60327-019-9_16
    9 sg:pub.10.1007/bf00360521
    10 sg:pub.10.1007/s00299-010-0938-1
    11 sg:pub.10.1007/s004390050904
    12 sg:pub.10.1007/s10162-012-0324-5
    13 sg:pub.10.1007/s12033-012-9613-9
    14 sg:pub.10.1007/s13238-014-0032-5
    15 sg:pub.10.1007/s13238-017-0458-7
    16 sg:pub.10.1038/gt.2008.145
    17 sg:pub.10.1038/gt.2015.30
    18 sg:pub.10.1038/nature.2016.19773
    19 sg:pub.10.1038/nature03556
    20 sg:pub.10.1038/nature06638
    21 sg:pub.10.1038/nature08434
    22 sg:pub.10.1038/nature09886
    23 sg:pub.10.1038/nature10886
    24 sg:pub.10.1038/nature11537
    25 sg:pub.10.1038/nature12477
    26 sg:pub.10.1038/nature12971
    27 sg:pub.10.1038/nature13011
    28 sg:pub.10.1038/nature13579
    29 sg:pub.10.1038/nature13769
    30 sg:pub.10.1038/nature14299
    31 sg:pub.10.1038/nature14592
    32 sg:pub.10.1038/nature16526
    33 sg:pub.10.1038/nature17946
    34 sg:pub.10.1038/nbt.1602
    35 sg:pub.10.1038/nbt.1731
    36 sg:pub.10.1038/nbt.1755
    37 sg:pub.10.1038/nbt.1767
    38 sg:pub.10.1038/nbt.1775
    39 sg:pub.10.1038/nbt.1934
    40 sg:pub.10.1038/nbt.1939
    41 sg:pub.10.1038/nbt.2357
    42 sg:pub.10.1038/nbt.2501
    43 sg:pub.10.1038/nbt.2507
    44 sg:pub.10.1038/nbt.2508
    45 sg:pub.10.1038/nbt.2517
    46 sg:pub.10.1038/nbt.2612
    47 sg:pub.10.1038/nbt.2623
    48 sg:pub.10.1038/nbt.2647
    49 sg:pub.10.1038/nbt.2673
    50 sg:pub.10.1038/nbt.2675
    51 sg:pub.10.1038/nbt.2808
    52 sg:pub.10.1038/nbt.2842
    53 sg:pub.10.1038/nbt.2884
    54 sg:pub.10.1038/nbt.2889
    55 sg:pub.10.1038/nbt.2908
    56 sg:pub.10.1038/nbt.2909
    57 sg:pub.10.1038/nbt.2916
    58 sg:pub.10.1038/nbt.3081
    59 sg:pub.10.1038/nbt.3117
    60 sg:pub.10.1038/nbt.3149
    61 sg:pub.10.1038/nbt.3190
    62 sg:pub.10.1038/nbt.3198
    63 sg:pub.10.1038/nbt.3404
    64 sg:pub.10.1038/nbt.3467
    65 sg:pub.10.1038/nbt.3481
    66 sg:pub.10.1038/nbt.3547
    67 sg:pub.10.1038/nbt.3803
    68 sg:pub.10.1038/nbt.3811
    69 sg:pub.10.1038/nbt.3816
    70 sg:pub.10.1038/nbt.3833
    71 sg:pub.10.1038/nbt.3852
    72 sg:pub.10.1038/nbt0298-153
    73 sg:pub.10.1038/nbt0714-599
    74 sg:pub.10.1038/nbt1101-1047
    75 sg:pub.10.1038/nbt1201-1173
    76 sg:pub.10.1038/nbt1319
    77 sg:pub.10.1038/nbt1353
    78 sg:pub.10.1038/nbt1398
    79 sg:pub.10.1038/nbt1402
    80 sg:pub.10.1038/nbt1409
    81 sg:pub.10.1038/nbt1410
    82 sg:pub.10.1038/nchembio.1793
    83 sg:pub.10.1038/ncomms15790
    84 sg:pub.10.1038/nm.3793
    85 sg:pub.10.1038/nm996
    86 sg:pub.10.1038/nmeth.1670
    87 sg:pub.10.1038/nmeth.2364
    88 sg:pub.10.1038/nmeth.2366
    89 sg:pub.10.1038/nmeth.2598
    90 sg:pub.10.1038/nmeth.2600
    91 sg:pub.10.1038/nmeth.2649
    92 sg:pub.10.1038/nmeth.2681
    93 sg:pub.10.1038/nmeth.3312
    94 sg:pub.10.1038/nmeth.4027
    95 sg:pub.10.1038/nmeth.4038
    96 sg:pub.10.1038/nmeth.4327
    97 sg:pub.10.1038/nprot.2011.431
    98 sg:pub.10.1038/nprot.2013.132
    99 sg:pub.10.1038/nprot.2013.143
    100 sg:pub.10.1038/nrc3179
    101 sg:pub.10.1038/nrd1087
    102 sg:pub.10.1038/nrg2380
    103 sg:pub.10.1038/nrg2842
    104 sg:pub.10.1038/nrm3486
    105 sg:pub.10.1038/nsmb.1744
    106 sg:pub.10.1038/nsmb.2019
    107 sg:pub.10.1038/nsmb.2879
    108 sg:pub.10.1038/s41467-017-00175-6
    109 sg:pub.10.1186/1471-2105-12-152
    110 sg:pub.10.1186/1471-2199-15-6
    111 sg:pub.10.1186/gb-2011-12-11-r112
    112 sg:pub.10.1186/s13059-014-0417-z
    113 sg:pub.10.1186/s13059-015-0584-6
    114 schema:datePublished 2018-06-19T00:00
    115 schema:description <p id="p-0001" num="0000">Compositions, methods, strategies, kits, and systems for the delivery of negatively charged proteins, protein complexes, and fusion proteins, using cationic polymers or lipids are provided. Delivery of proteins into cells can be effected in vivo, ex vivo, or in vitro. Proteins that can be delivered using the compositions, methods, strategies, kits, and systems provided herein include, without limitation, enzymes, transcription factors, genome editing proteins, Cas9 proteins, TALEs, TALENs, nucleases, binding proteins (e.g., ligands, receptors, antibodies, antibody fragments; nucleic acid binding proteins, etc.), structural proteins, and therapeutic proteins (e.g., tumor suppressor proteins, therapeutic enzymes, growth factors, growth factor receptors, transcription factors, proteases, etc.), as well as variants and fusions of such proteins.</p>
    116 schema:endDate 2035-11-21
    117 schema:name Delivery of negatively charged proteins using cationic lipids
    118 schema:recipient grid-institutes:grid.38142.3c
    119 schema:sameAs https://app.dimensions.ai/details/patent/US-9999671-B2
    120 schema:sdDatePublished 2022-09-02T16:21
    121 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    122 schema:sdPublisher Nd2bc5039bd1f43cda2df5dcbf70bcfee
    123 sgo:license sg:explorer/license/
    124 sgo:sdDataset patents
    125 rdf:type sgo:Patent
    126 N0aefdc846c104cda9dc20d3652250f9b rdf:first Naaeb4e602b8d4ffe9d16312d186f189f
    127 rdf:rest rdf:nil
    128 N4caa4ba9421a43bbbb2a72f58a1798ec schema:name THOMPSON DAVID B
    129 rdf:type schema:Person
    130 N778ebca198a449f4b4cc9e69e0f647c7 schema:name LIU DAVID R
    131 rdf:type schema:Person
    132 N96a56d0be0b14a669fc1b3789072fa72 rdf:first N4caa4ba9421a43bbbb2a72f58a1798ec
    133 rdf:rest N0aefdc846c104cda9dc20d3652250f9b
    134 Naaeb4e602b8d4ffe9d16312d186f189f schema:name ZURIS JOHN ANTHONY
    135 rdf:type schema:Person
    136 Nd1bb571c165a456ea547072ec17f62e8 rdf:first N778ebca198a449f4b4cc9e69e0f647c7
    137 rdf:rest N96a56d0be0b14a669fc1b3789072fa72
    138 Nd2bc5039bd1f43cda2df5dcbf70bcfee schema:name Springer Nature - SN SciGraph project
    139 rdf:type schema:Organization
    140 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    141 rdf:type schema:DefinedTerm
    142 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    143 rdf:type schema:DefinedTerm
    144 sg:pub.10.1007/978-1-59745-232-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011938717
    145 https://doi.org/10.1007/978-1-59745-232-8
    146 rdf:type schema:CreativeWork
    147 sg:pub.10.1007/978-1-59745-232-8_4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040102050
    148 https://doi.org/10.1007/978-1-59745-232-8_4
    149 rdf:type schema:CreativeWork
    150 sg:pub.10.1007/978-1-59745-232-8_5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043561019
    151 https://doi.org/10.1007/978-1-59745-232-8_5
    152 rdf:type schema:CreativeWork
    153 sg:pub.10.1007/978-1-60327-019-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045514102
    154 https://doi.org/10.1007/978-1-60327-019-9
    155 rdf:type schema:CreativeWork
    156 sg:pub.10.1007/978-1-60327-019-9_16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040082301
    157 https://doi.org/10.1007/978-1-60327-019-9_16
    158 rdf:type schema:CreativeWork
    159 sg:pub.10.1007/bf00360521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038349147
    160 https://doi.org/10.1007/bf00360521
    161 rdf:type schema:CreativeWork
    162 sg:pub.10.1007/s00299-010-0938-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044696716
    163 https://doi.org/10.1007/s00299-010-0938-1
    164 rdf:type schema:CreativeWork
    165 sg:pub.10.1007/s004390050904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035082076
    166 https://doi.org/10.1007/s004390050904
    167 rdf:type schema:CreativeWork
    168 sg:pub.10.1007/s10162-012-0324-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019406988
    169 https://doi.org/10.1007/s10162-012-0324-5
    170 rdf:type schema:CreativeWork
    171 sg:pub.10.1007/s12033-012-9613-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031558495
    172 https://doi.org/10.1007/s12033-012-9613-9
    173 rdf:type schema:CreativeWork
    174 sg:pub.10.1007/s13238-014-0032-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051855442
    175 https://doi.org/10.1007/s13238-014-0032-5
    176 rdf:type schema:CreativeWork
    177 sg:pub.10.1007/s13238-017-0458-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091243310
    178 https://doi.org/10.1007/s13238-017-0458-7
    179 rdf:type schema:CreativeWork
    180 sg:pub.10.1038/gt.2008.145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045636817
    181 https://doi.org/10.1038/gt.2008.145
    182 rdf:type schema:CreativeWork
    183 sg:pub.10.1038/gt.2015.30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005185460
    184 https://doi.org/10.1038/gt.2015.30
    185 rdf:type schema:CreativeWork
    186 sg:pub.10.1038/nature.2016.19773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056448921
    187 https://doi.org/10.1038/nature.2016.19773
    188 rdf:type schema:CreativeWork
    189 sg:pub.10.1038/nature03556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040117781
    190 https://doi.org/10.1038/nature03556
    191 rdf:type schema:CreativeWork
    192 sg:pub.10.1038/nature06638 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015857224
    193 https://doi.org/10.1038/nature06638
    194 rdf:type schema:CreativeWork
    195 sg:pub.10.1038/nature08434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042379011
    196 https://doi.org/10.1038/nature08434
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1038/nature09886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030591890
    199 https://doi.org/10.1038/nature09886
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1038/nature10886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053669571
    202 https://doi.org/10.1038/nature10886
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1038/nature11537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021191816
    205 https://doi.org/10.1038/nature11537
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1038/nature12477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050004918
    208 https://doi.org/10.1038/nature12477
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1038/nature12971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052410148
    211 https://doi.org/10.1038/nature12971
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1038/nature13011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037342101
    214 https://doi.org/10.1038/nature13011
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1038/nature13579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036390967
    217 https://doi.org/10.1038/nature13579
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1038/nature13769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009875984
    220 https://doi.org/10.1038/nature13769
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1038/nature14299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019168198
    223 https://doi.org/10.1038/nature14299
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1038/nature14592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047292250
    226 https://doi.org/10.1038/nature14592
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1038/nature16526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010800066
    229 https://doi.org/10.1038/nature16526
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1038/nature17946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009172001
    232 https://doi.org/10.1038/nature17946
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/nbt.1602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051671503
    235 https://doi.org/10.1038/nbt.1602
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/nbt.1731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030230970
    238 https://doi.org/10.1038/nbt.1731
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/nbt.1755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016004947
    241 https://doi.org/10.1038/nbt.1755
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1038/nbt.1767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022298591
    244 https://doi.org/10.1038/nbt.1767
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1038/nbt.1775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031104364
    247 https://doi.org/10.1038/nbt.1775
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1038/nbt.1934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010658010
    250 https://doi.org/10.1038/nbt.1934
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1038/nbt.1939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010610351
    253 https://doi.org/10.1038/nbt.1939
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/nbt.2357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014043446
    256 https://doi.org/10.1038/nbt.2357
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/nbt.2501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024988605
    259 https://doi.org/10.1038/nbt.2501
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/nbt.2507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041881936
    262 https://doi.org/10.1038/nbt.2507
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/nbt.2508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019888616
    265 https://doi.org/10.1038/nbt.2508
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/nbt.2517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017042091
    268 https://doi.org/10.1038/nbt.2517
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1038/nbt.2612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003176820
    271 https://doi.org/10.1038/nbt.2612
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1038/nbt.2623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009511624
    274 https://doi.org/10.1038/nbt.2623
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1038/nbt.2647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012543463
    277 https://doi.org/10.1038/nbt.2647
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1038/nbt.2673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007302590
    280 https://doi.org/10.1038/nbt.2673
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1038/nbt.2675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041659759
    283 https://doi.org/10.1038/nbt.2675
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1038/nbt.2808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048637524
    286 https://doi.org/10.1038/nbt.2808
    287 rdf:type schema:CreativeWork
    288 sg:pub.10.1038/nbt.2842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038520013
    289 https://doi.org/10.1038/nbt.2842
    290 rdf:type schema:CreativeWork
    291 sg:pub.10.1038/nbt.2884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011531387
    292 https://doi.org/10.1038/nbt.2884
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1038/nbt.2889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043519930
    295 https://doi.org/10.1038/nbt.2889
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1038/nbt.2908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012868720
    298 https://doi.org/10.1038/nbt.2908
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1038/nbt.2909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053226125
    301 https://doi.org/10.1038/nbt.2909
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1038/nbt.2916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043348902
    304 https://doi.org/10.1038/nbt.2916
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1038/nbt.3081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017697957
    307 https://doi.org/10.1038/nbt.3081
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1038/nbt.3117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021849416
    310 https://doi.org/10.1038/nbt.3117
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1038/nbt.3149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034330725
    313 https://doi.org/10.1038/nbt.3149
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1038/nbt.3190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017538548
    316 https://doi.org/10.1038/nbt.3190
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1038/nbt.3198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008895789
    319 https://doi.org/10.1038/nbt.3198
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1038/nbt.3404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052861805
    322 https://doi.org/10.1038/nbt.3404
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1038/nbt.3467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020093829
    325 https://doi.org/10.1038/nbt.3467
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1038/nbt.3481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004939292
    328 https://doi.org/10.1038/nbt.3481
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1038/nbt.3547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047211077
    331 https://doi.org/10.1038/nbt.3547
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1038/nbt.3803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083803971
    334 https://doi.org/10.1038/nbt.3803
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1038/nbt.3811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084128647
    337 https://doi.org/10.1038/nbt.3811
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1038/nbt.3816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084128652
    340 https://doi.org/10.1038/nbt.3816
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1038/nbt.3833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084128666
    343 https://doi.org/10.1038/nbt.3833
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1038/nbt.3852 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084753472
    346 https://doi.org/10.1038/nbt.3852
    347 rdf:type schema:CreativeWork
    348 sg:pub.10.1038/nbt0298-153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019139570
    349 https://doi.org/10.1038/nbt0298-153
    350 rdf:type schema:CreativeWork
    351 sg:pub.10.1038/nbt0714-599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049485528
    352 https://doi.org/10.1038/nbt0714-599
    353 rdf:type schema:CreativeWork
    354 sg:pub.10.1038/nbt1101-1047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023451333
    355 https://doi.org/10.1038/nbt1101-1047
    356 rdf:type schema:CreativeWork
    357 sg:pub.10.1038/nbt1201-1173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033003564
    358 https://doi.org/10.1038/nbt1201-1173
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1038/nbt1319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002154526
    361 https://doi.org/10.1038/nbt1319
    362 rdf:type schema:CreativeWork
    363 sg:pub.10.1038/nbt1353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026122095
    364 https://doi.org/10.1038/nbt1353
    365 rdf:type schema:CreativeWork
    366 sg:pub.10.1038/nbt1398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032856466
    367 https://doi.org/10.1038/nbt1398
    368 rdf:type schema:CreativeWork
    369 sg:pub.10.1038/nbt1402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029302550
    370 https://doi.org/10.1038/nbt1402
    371 rdf:type schema:CreativeWork
    372 sg:pub.10.1038/nbt1409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045837461
    373 https://doi.org/10.1038/nbt1409
    374 rdf:type schema:CreativeWork
    375 sg:pub.10.1038/nbt1410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048577624
    376 https://doi.org/10.1038/nbt1410
    377 rdf:type schema:CreativeWork
    378 sg:pub.10.1038/nchembio.1793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042535273
    379 https://doi.org/10.1038/nchembio.1793
    380 rdf:type schema:CreativeWork
    381 sg:pub.10.1038/ncomms15790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085880702
    382 https://doi.org/10.1038/ncomms15790
    383 rdf:type schema:CreativeWork
    384 sg:pub.10.1038/nm.3793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052797737
    385 https://doi.org/10.1038/nm.3793
    386 rdf:type schema:CreativeWork
    387 sg:pub.10.1038/nm996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040467981
    388 https://doi.org/10.1038/nm996
    389 rdf:type schema:CreativeWork
    390 sg:pub.10.1038/nmeth.1670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043918422
    391 https://doi.org/10.1038/nmeth.1670
    392 rdf:type schema:CreativeWork
    393 sg:pub.10.1038/nmeth.2364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015862962
    394 https://doi.org/10.1038/nmeth.2364
    395 rdf:type schema:CreativeWork
    396 sg:pub.10.1038/nmeth.2366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040994508
    397 https://doi.org/10.1038/nmeth.2366
    398 rdf:type schema:CreativeWork
    399 sg:pub.10.1038/nmeth.2598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049500416
    400 https://doi.org/10.1038/nmeth.2598
    401 rdf:type schema:CreativeWork
    402 sg:pub.10.1038/nmeth.2600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024354143
    403 https://doi.org/10.1038/nmeth.2600
    404 rdf:type schema:CreativeWork
    405 sg:pub.10.1038/nmeth.2649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008703730
    406 https://doi.org/10.1038/nmeth.2649
    407 rdf:type schema:CreativeWork
    408 sg:pub.10.1038/nmeth.2681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028304735
    409 https://doi.org/10.1038/nmeth.2681
    410 rdf:type schema:CreativeWork
    411 sg:pub.10.1038/nmeth.3312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008897838
    412 https://doi.org/10.1038/nmeth.3312
    413 rdf:type schema:CreativeWork
    414 sg:pub.10.1038/nmeth.4027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038829252
    415 https://doi.org/10.1038/nmeth.4027
    416 rdf:type schema:CreativeWork
    417 sg:pub.10.1038/nmeth.4038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030846996
    418 https://doi.org/10.1038/nmeth.4038
    419 rdf:type schema:CreativeWork
    420 sg:pub.10.1038/nmeth.4327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085864346
    421 https://doi.org/10.1038/nmeth.4327
    422 rdf:type schema:CreativeWork
    423 sg:pub.10.1038/nprot.2011.431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020679703
    424 https://doi.org/10.1038/nprot.2011.431
    425 rdf:type schema:CreativeWork
    426 sg:pub.10.1038/nprot.2013.132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009361018
    427 https://doi.org/10.1038/nprot.2013.132
    428 rdf:type schema:CreativeWork
    429 sg:pub.10.1038/nprot.2013.143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016534425
    430 https://doi.org/10.1038/nprot.2013.143
    431 rdf:type schema:CreativeWork
    432 sg:pub.10.1038/nrc3179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052351170
    433 https://doi.org/10.1038/nrc3179
    434 rdf:type schema:CreativeWork
    435 sg:pub.10.1038/nrd1087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040287926
    436 https://doi.org/10.1038/nrd1087
    437 rdf:type schema:CreativeWork
    438 sg:pub.10.1038/nrg2380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041270694
    439 https://doi.org/10.1038/nrg2380
    440 rdf:type schema:CreativeWork
    441 sg:pub.10.1038/nrg2842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018939216
    442 https://doi.org/10.1038/nrg2842
    443 rdf:type schema:CreativeWork
    444 sg:pub.10.1038/nrm3486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050461034
    445 https://doi.org/10.1038/nrm3486
    446 rdf:type schema:CreativeWork
    447 sg:pub.10.1038/nsmb.1744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002558962
    448 https://doi.org/10.1038/nsmb.1744
    449 rdf:type schema:CreativeWork
    450 sg:pub.10.1038/nsmb.2019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011829375
    451 https://doi.org/10.1038/nsmb.2019
    452 rdf:type schema:CreativeWork
    453 sg:pub.10.1038/nsmb.2879 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010082311
    454 https://doi.org/10.1038/nsmb.2879
    455 rdf:type schema:CreativeWork
    456 sg:pub.10.1038/s41467-017-00175-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090780642
    457 https://doi.org/10.1038/s41467-017-00175-6
    458 rdf:type schema:CreativeWork
    459 sg:pub.10.1186/1471-2105-12-152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031107821
    460 https://doi.org/10.1186/1471-2105-12-152
    461 rdf:type schema:CreativeWork
    462 sg:pub.10.1186/1471-2199-15-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018784555
    463 https://doi.org/10.1186/1471-2199-15-6
    464 rdf:type schema:CreativeWork
    465 sg:pub.10.1186/gb-2011-12-11-r112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027516867
    466 https://doi.org/10.1186/gb-2011-12-11-r112
    467 rdf:type schema:CreativeWork
    468 sg:pub.10.1186/s13059-014-0417-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1025106002
    469 https://doi.org/10.1186/s13059-014-0417-z
    470 rdf:type schema:CreativeWork
    471 sg:pub.10.1186/s13059-015-0584-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024223648
    472 https://doi.org/10.1186/s13059-015-0584-6
    473 rdf:type schema:CreativeWork
    474 grid-institutes:grid.38142.3c schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...