Cytotoxicity-inducing theraputic agent


Ontology type: sgo:Patent     


Patent Info

DATE

2018-05-22T00:00

AUTHORS

Junichi Nezu , Atsushi Narita , Takahiro Ishiguro , Mika Sakurai , Hirotake Shiraiwa , Naoka Hironiwa , Tomoyuki Igawa , Yumiko Kawai

ABSTRACT

Novel multispecific antigen-binding molecules maintaining excellent cellular cytotoxicity and high stability, which comprise a domain that contains an antibody variable region having glypican 3-binding activity and a domain that contains an antibody variable region having T-cell receptor complex-binding activity, were discovered. Since the molecules of the present invention show a strong cytotoxicity against cells and tissues expressing glypican 3, it is possible to produce novel pharmaceutical compositions for treating or preventing various cancers. More... »

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