Methods for increasing CAS9-mediated engineering efficiency


Ontology type: sgo:Patent     


Patent Info

DATE

2018-05-15T00:00

AUTHORS

Peter Sean Cameron , Rachel E. Haurwitz , Andrew P. May , Christopher H. Nye , Megan van Overbeek

ABSTRACT

Methods for use with Type II CRISPR-Cas9 systems for increasing Cas9-mediated genome engineering efficiency are disclosed. The methods can be used to decrease the number of off-target nucleic acid double-stranded breaks and/or to enhance homology-directed repair of a cleaved target nucleic acid.

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