Platinum compounds that inhibit constitutive STAT3 signaling and induce cell cycle arrest and apoptosis of malignant cells


Ontology type: sgo:Patent     


Patent Info

DATE

2018-05-15T00:00

AUTHORS

SEBTI SAID M , LAWRENCE NICHOLAS J , TURKSON JAMES

ABSTRACT

The subject invention concerns a compound and compositions having activity as an inhibitor of Stat3 protein and methods of using the compound and compositions. In one embodiment, a compound of the invention has the structure shown in formula I, formula II, or formula III. The subject invention also concerns methods of using the compounds and compositions of the invention. More... »

Related SciGraph Publications

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  • 1999-05-01. Isolation and chromosomal assignment of a human gene encoding protein inhibitor of activated STAT3 (PIAS3) in JOURNAL OF HUMAN GENETICS
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  • 2000-12-27. STAT proteins: novel molecular targets for cancer drug discovery in ONCOGENE
  • 2002-03-21. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis in ONCOGENE
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