Methods and compositions for targeted gene modification


Ontology type: sgo:Patent     


Patent Info

DATE

2018-05-01T00:00

AUTHORS

PETER R. BEETHAM , Gregory F. W. Gocal , Christian Schopke , Noel SAUER , James Pearce , Rosa E. SEGAMI , Jerry MOZORUK

ABSTRACT

Provided herein include methods and compositions for effecting a targeted genetic change in DNA in a cell. Certain aspects and embodiments relate to improving the efficiency of the targeting of modifications to specific locations in genomic or other nucleotide sequences. As described herein, nucleic acids which direct specific changes to the genome may be combined with various approaches to enhance the availability of components of the natural repair systems present in the cells being targeted for modification. More... »

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