Engineered CRISPR-Cas9 nucleases with altered PAM specificity


Ontology type: sgo:Patent     


Patent Info

DATE

2018-04-17T00:00

AUTHORS

J. Keith Joung , Benjamin Kleinstiver

ABSTRACT

Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.

Related SciGraph Publications

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  • 2013-09. DNA targeting specificity of RNA-guided Cas9 nucleases in NATURE BIOTECHNOLOGY
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  • 2014-09. Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease in NATURE
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  • 2014-06. Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification in NATURE BIOTECHNOLOGY
  • 2015-06-22. Engineered CRISPR-Cas9 nucleases with altered PAM specificities in NATURE
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