Haplotying of HLA loci with ultra-deep shotgun sequencing


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Chunlin Wang , Michael N. Mindrinos , Mark M. Davis , Ronald W. Davis , Sujatha Krishnakumar

ABSTRACT

Methods are provided to determine the entire genomic region of a particular HLA locus including both intron and exons. The resultant consensus sequences provides linkage information between different exons, and produces the unique sequence from each of the two genes from the individual sample being typed. The sequence information in intron regions along with the exon sequences provides an accurate HLA haplotype. More... »

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