Nucleic acid-based linkers for detecting and measuring interactions


Ontology type: sgo:Patent     


Patent Info

DATE

2018-03-13T00:00

AUTHORS

Wesley Philip Wong , Kenneth Anders Halvorsen

ABSTRACT

The invention provides compositions comprising nucleic acid complexes for use in monitoring binding interactions and in measuring association and/or dissociation kinetics with or without force, detecting analytes, screening aptamers, and encoding/encrypting information. In some instances, the nucleic acid complexes are double-stranded nicked nucleic acids comprising a scaffold nucleic acid hybridized to one or more oligonucleotides. In some instances, a first and/or a second oligonucleotide are linked to moieties that are known to interact with each other or which are suspected of interacting with each other. More... »

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