Induction of pluripotent cells


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Tongxiang Lin , Sheng Ding

ABSTRACT

The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, non-viral methods for reprogramming human somatic cells. More... »

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