Markers for pre-cancer and cancer cells and the method to interfere with cell proliferation therein


Ontology type: sgo:Patent     


Patent Info

DATE

2018-02-27T00:00

AUTHORS

Luis O. Burzio , Jaime E. Villegas , Veronica A. Burzio

ABSTRACT

A novel family of human mitochondrial RNAs, referred to as chimeric RNAs, which are differentially expressed in normal, pre-cancer and cancer cells, are described. Oligonucleotides targeted to the chimeric RNAs are provided. The described oligonucleotides or their analogs can be used for cancer diagnostics and cancer therapy as well as for research. In one embodiment of this invention, these oligonucleotides hybridize with the sense or with the antisense mitochondrial chimeric RNAs, and the result of the hybridization is useful to differentiate between normal proliferating cells, pre-cancer cells and cancer cells. In another embodiment of the invention, the compositions comprise oligonucleotides that hybridize with the human chimeric RNAs resulting in cancer cell and pre-cancer cell death, while there is no effect in normal cells, constituting therefore, a novel approach for cancer therapy. More... »

Related SciGraph Publications

  • 2002-08. Tumor-targeting, Systemically Delivered Antisense HER-2 Chemosensitizes Human Breast Cancer Xenografts Irrespective of HER-2 Levels in MOLECULAR MEDICINE
  • 2002-10. Gene silencing in mammals by small interfering RNAs in NATURE REVIEWS GENETICS
  • 2000-10. Apoptosis in development in NATURE
  • 2001-05. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells in NATURE
  • 2003-12. Approaches for the sequence-specific knockdown of mRNA in NATURE BIOTECHNOLOGY
  • 2000-05. Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN in NATURE MEDICINE
  • 2001-11. Organelle-specific initiation of cell death pathways in NATURE CELL BIOLOGY
  • 2003-01. Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots in NATURE BIOTECHNOLOGY
  • 2001-09. Heat-shock protein 70 antagonizes apoptosis-inducing factor in NATURE CELL BIOLOGY
  • 1967-11. Circular Dimer and Catenate Forms of Mitochondrial DNA in Human Leukaemic Leucocytes in NATURE
  • 2000-10. CD95's deadly mission in the immune system in NATURE
  • 2000-11. Surfing the p53 network in NATURE
  • 2003-01. Characterization of the mouse genes for mitochondrial transcription factors B1 and B2 in MAMMALIAN GENOME
  • 1981-03. In vivo sequence requirements of the SV40 early promoter region in NATURE
  • 1993-10. PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules in NATURE
  • 2005-01. Inhibition of respiratory viruses by nasally administered siRNA in NATURE MEDICINE
  • 2002-07. Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA in NATURE GENETICS
  • 2002-09. Efficient delivery of siRNA for inhibition of gene expression in postnatal mice in NATURE GENETICS
  • 2004-04. Lysosomes in cell death in ONCOGENE
  • 1982-03. Regulation of metallothionein–thymidine kinase fusion plasmids injected into mouse eggs in NATURE
  • 2004-11. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs in NATURE
  • 2001-07. Endonuclease G is an apoptotic DNase when released from mitochondria in NATURE
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/3142", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2581", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "name": "Luis O. Burzio", 
            "type": "Person"
          }, 
          {
            "name": "Jaime E. Villegas", 
            "type": "Person"
          }, 
          {
            "name": "Veronica A. Burzio", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/s1357-4310(00)01805-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000062054"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0958-1669(97)80008-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000332835"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(89)90028-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000640149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(89)90028-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000640149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.19.11274", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001260347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/6.4.615", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001640695"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0378-1119(00)00224-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002450910"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg908", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003050911", 
              "https://doi.org/10.1038/nrg908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg908", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003050911", 
              "https://doi.org/10.1038/nrg908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.184.2.747", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003146420"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt915", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003713111", 
              "https://doi.org/10.1038/nbt915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt915", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003713111", 
              "https://doi.org/10.1038/nbt915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/365566a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004328835", 
              "https://doi.org/10.1038/365566a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/molehr/8.11.977", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004816542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.274.9.5953", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005593721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0235524100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007256345"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35083620", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009664464", 
              "https://doi.org/10.1038/35083620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35083620", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009664464", 
              "https://doi.org/10.1038/35083620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(01)00341-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009904849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.273.49.32608", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010114830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.78.3.1441", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012274586"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m210326200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014989445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/296039a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015256219", 
              "https://doi.org/10.1038/296039a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016341645", 
              "https://doi.org/10.1038/ng909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016341645", 
              "https://doi.org/10.1038/ng909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.191.7.1095", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016781884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2003.08.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016995374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.171251798", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017733703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.189.5.821", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019798068"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1207512", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019973027", 
              "https://doi.org/10.1038/sj.onc.1207512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1207512", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019973027", 
              "https://doi.org/10.1038/sj.onc.1207512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m208766200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020523792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/humrep/15.suppl_2.11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020870698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35037728", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022325441", 
              "https://doi.org/10.1038/35037728"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35037728", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022325441", 
              "https://doi.org/10.1038/35037728"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkh220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022828371"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35042675", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023763406", 
              "https://doi.org/10.1038/35042675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35042675", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023763406", 
              "https://doi.org/10.1038/35042675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt764", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023895188", 
              "https://doi.org/10.1038/nbt764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt764", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023895188", 
              "https://doi.org/10.1038/nbt764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/75007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024503242", 
              "https://doi.org/10.1038/75007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/75007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024503242", 
              "https://doi.org/10.1038/75007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1525-0016(03)00244-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026323120"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.275.12.8461", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027290425"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35078107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028423924", 
              "https://doi.org/10.1038/35078107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35078107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028423924", 
              "https://doi.org/10.1038/35078107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkg185", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028892999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.74.19.8793-8802.2000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029628199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00335-002-2218-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032289892", 
              "https://doi.org/10.1007/s00335-002-2218-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkg409", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033210251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0005-2728(98)00161-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034650442"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1517/17425247.2.1.3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034720714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/19.7.1437", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034993468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m107206200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035049705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkf598", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035615795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb0901-839", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036269889", 
              "https://doi.org/10.1038/ncb0901-839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb0901-839", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036269889", 
              "https://doi.org/10.1038/ncb0901-839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1101-e255", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036625499", 
              "https://doi.org/10.1038/ncb1101-e255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1101-e255", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036625499", 
              "https://doi.org/10.1038/ncb1101-e255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.97.10.5633", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036956205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.274.3.1715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037046577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/28.9.e40", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038384204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/290304a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038808547", 
              "https://doi.org/10.1038/290304a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m108844200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039717734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35037734", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040101069", 
              "https://doi.org/10.1038/35037734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35037734", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040101069", 
              "https://doi.org/10.1038/35037734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.62.4.1077", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040289760"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m109784200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041697993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.274.30.20855", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041778391"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/28.11.2242", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041873408"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0968-0896(95)00171-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041892923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0167-4781(99)00150-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042006194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0167-4781(99)00150-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042006194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.0956-5507.2003.00090.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042292798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng944", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042354461", 
              "https://doi.org/10.1038/ng944"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng944", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042354461", 
              "https://doi.org/10.1038/ng944"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m301392200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042857775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0402630101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043067468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03121", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043296399", 
              "https://doi.org/10.1038/nature03121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03121", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043296399", 
              "https://doi.org/10.1038/nature03121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/30.9.1895", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043940343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-291x(03)00630-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046627049"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-291x(03)00630-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046627049"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(00)00106-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049321303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.22.4.1116-1125.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049392410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0903086106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049581730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1386-6532(02)00234-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051430425"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1386-6532(02)00234-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051430425"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051572486", 
              "https://doi.org/10.1038/nm1164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051572486", 
              "https://doi.org/10.1038/nm1164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(80)90555-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052344297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/216652a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053544698", 
              "https://doi.org/10.1038/216652a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/216652a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053544698", 
              "https://doi.org/10.1038/216652a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi00245a001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055166843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/104454900439809", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059203577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/154545703322617078", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059216015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.123.3191.309", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062467291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.2035027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062519239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.275.5302.967", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062555784"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.285.5434.1733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062566572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.6200938", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062635713"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1999.17.9.2941", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074549931"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf03402027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075191622", 
              "https://doi.org/10.1007/bf03402027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1984.tb01974.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1081559826"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-02-27T00:00", 
        "description": "

    A novel family of human mitochondrial RNAs, referred to as chimeric RNAs, which are differentially expressed in normal, pre-cancer and cancer cells, are described. Oligonucleotides targeted to the chimeric RNAs are provided. The described oligonucleotides or their analogs can be used for cancer diagnostics and cancer therapy as well as for research. In one embodiment of this invention, these oligonucleotides hybridize with the sense or with the antisense mitochondrial chimeric RNAs, and the result of the hybridization is useful to differentiate between normal proliferating cells, pre-cancer cells and cancer cells. In another embodiment of the invention, the compositions comprise oligonucleotides that hybridize with the human chimeric RNAs resulting in cancer cell and pre-cancer cell death, while there is no effect in normal cells, constituting therefore, a novel approach for cancer therapy.

    ", "id": "sg:patent.US-9903000-B2", "keywords": [ "marker", "pre-cancer", "cancer cell", "method", "cell proliferation", "novel family", "human", "RNA", "oligonucleotides", "analog", "cancer diagnostics", "cancer therapy", "embodiment", "invention", "hybridization", "cell", "composition", "hybridize", "cancer cell death", "normal cell", "novel approach" ], "name": "Markers for pre-cancer and cancer cells and the method to interfere with cell proliferation therein", "sameAs": [ "https://app.dimensions.ai/details/patent/US-9903000-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:22", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_01695.jsonl", "type": "Patent" } ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-9903000-B2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-9903000-B2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-9903000-B2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-9903000-B2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    323 TRIPLES      14 PREDICATES      118 URIs      29 LITERALS      2 BLANK NODES

    Subject Predicate Object
    1 sg:patent.US-9903000-B2 schema:about anzsrc-for:2581
    2 anzsrc-for:3142
    3 schema:author Nd7ad5c8ef70442a8a6faa96c2245c933
    4 schema:citation sg:pub.10.1007/bf03402027
    5 sg:pub.10.1007/s00335-002-2218-z
    6 sg:pub.10.1038/216652a0
    7 sg:pub.10.1038/290304a0
    8 sg:pub.10.1038/296039a0
    9 sg:pub.10.1038/35037728
    10 sg:pub.10.1038/35037734
    11 sg:pub.10.1038/35042675
    12 sg:pub.10.1038/35078107
    13 sg:pub.10.1038/35083620
    14 sg:pub.10.1038/365566a0
    15 sg:pub.10.1038/75007
    16 sg:pub.10.1038/nature03121
    17 sg:pub.10.1038/nbt764
    18 sg:pub.10.1038/nbt915
    19 sg:pub.10.1038/ncb0901-839
    20 sg:pub.10.1038/ncb1101-e255
    21 sg:pub.10.1038/ng909
    22 sg:pub.10.1038/ng944
    23 sg:pub.10.1038/nm1164
    24 sg:pub.10.1038/nrg908
    25 sg:pub.10.1038/sj.onc.1207512
    26 https://doi.org/10.1002/j.1460-2075.1984.tb01974.x
    27 https://doi.org/10.1016/0092-8674(80)90555-3
    28 https://doi.org/10.1016/0378-1119(89)90028-0
    29 https://doi.org/10.1016/0968-0896(95)00171-9
    30 https://doi.org/10.1016/j.bbrc.2003.08.021
    31 https://doi.org/10.1016/s0005-2728(98)00161-3
    32 https://doi.org/10.1016/s0006-291x(03)00630-2
    33 https://doi.org/10.1016/s0167-4781(99)00150-5
    34 https://doi.org/10.1016/s0378-1119(00)00224-9
    35 https://doi.org/10.1016/s0958-1669(97)80008-0
    36 https://doi.org/10.1016/s0960-9822(00)00106-8
    37 https://doi.org/10.1016/s1097-2765(01)00341-0
    38 https://doi.org/10.1016/s1357-4310(00)01805-0
    39 https://doi.org/10.1016/s1386-6532(02)00234-2
    40 https://doi.org/10.1016/s1525-0016(03)00244-2
    41 https://doi.org/10.1021/bi00245a001
    42 https://doi.org/10.1046/j.0956-5507.2003.00090.x
    43 https://doi.org/10.1073/pnas.0235524100
    44 https://doi.org/10.1073/pnas.0402630101
    45 https://doi.org/10.1073/pnas.0903086106
    46 https://doi.org/10.1073/pnas.171251798
    47 https://doi.org/10.1073/pnas.62.4.1077
    48 https://doi.org/10.1073/pnas.78.3.1441
    49 https://doi.org/10.1073/pnas.95.19.11274
    50 https://doi.org/10.1073/pnas.97.10.5633
    51 https://doi.org/10.1074/jbc.273.49.32608
    52 https://doi.org/10.1074/jbc.274.3.1715
    53 https://doi.org/10.1074/jbc.274.30.20855
    54 https://doi.org/10.1074/jbc.274.9.5953
    55 https://doi.org/10.1074/jbc.275.12.8461
    56 https://doi.org/10.1074/jbc.m107206200
    57 https://doi.org/10.1074/jbc.m108844200
    58 https://doi.org/10.1074/jbc.m109784200
    59 https://doi.org/10.1074/jbc.m208766200
    60 https://doi.org/10.1074/jbc.m210326200
    61 https://doi.org/10.1074/jbc.m301392200
    62 https://doi.org/10.1084/jem.184.2.747
    63 https://doi.org/10.1084/jem.189.5.821
    64 https://doi.org/10.1084/jem.191.7.1095
    65 https://doi.org/10.1089/104454900439809
    66 https://doi.org/10.1089/154545703322617078
    67 https://doi.org/10.1093/hmg/6.4.615
    68 https://doi.org/10.1093/humrep/15.suppl_2.11
    69 https://doi.org/10.1093/molehr/8.11.977
    70 https://doi.org/10.1093/nar/19.7.1437
    71 https://doi.org/10.1093/nar/28.11.2242
    72 https://doi.org/10.1093/nar/28.9.e40
    73 https://doi.org/10.1093/nar/30.9.1895
    74 https://doi.org/10.1093/nar/gkf598
    75 https://doi.org/10.1093/nar/gkg185
    76 https://doi.org/10.1093/nar/gkg409
    77 https://doi.org/10.1093/nar/gkh220
    78 https://doi.org/10.1126/science.123.3191.309
    79 https://doi.org/10.1126/science.2035027
    80 https://doi.org/10.1126/science.275.5302.967
    81 https://doi.org/10.1126/science.285.5434.1733
    82 https://doi.org/10.1126/science.6200938
    83 https://doi.org/10.1128/jvi.74.19.8793-8802.2000
    84 https://doi.org/10.1128/mcb.22.4.1116-1125.2002
    85 https://doi.org/10.1200/jco.1999.17.9.2941
    86 https://doi.org/10.1517/17425247.2.1.3
    87 schema:datePublished 2018-02-27T00:00
    88 schema:description <p id="p-0001" num="0000">A novel family of human mitochondrial RNAs, referred to as chimeric RNAs, which are differentially expressed in normal, pre-cancer and cancer cells, are described. Oligonucleotides targeted to the chimeric RNAs are provided. The described oligonucleotides or their analogs can be used for cancer diagnostics and cancer therapy as well as for research. In one embodiment of this invention, these oligonucleotides hybridize with the sense or with the antisense mitochondrial chimeric RNAs, and the result of the hybridization is useful to differentiate between normal proliferating cells, pre-cancer cells and cancer cells. In another embodiment of the invention, the compositions comprise oligonucleotides that hybridize with the human chimeric RNAs resulting in cancer cell and pre-cancer cell death, while there is no effect in normal cells, constituting therefore, a novel approach for cancer therapy.</p>
    89 schema:keywords RNA
    90 analog
    91 cancer cell
    92 cancer cell death
    93 cancer diagnostics
    94 cancer therapy
    95 cell
    96 cell proliferation
    97 composition
    98 embodiment
    99 human
    100 hybridization
    101 hybridize
    102 invention
    103 marker
    104 method
    105 normal cell
    106 novel approach
    107 novel family
    108 oligonucleotides
    109 pre-cancer
    110 schema:name Markers for pre-cancer and cancer cells and the method to interfere with cell proliferation therein
    111 schema:sameAs https://app.dimensions.ai/details/patent/US-9903000-B2
    112 schema:sdDatePublished 2019-04-18T10:22
    113 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    114 schema:sdPublisher N81833844d6cf4175b437f71ad9f3f82a
    115 sgo:license sg:explorer/license/
    116 sgo:sdDataset patents
    117 rdf:type sgo:Patent
    118 N67a4b276ffcd45ccab0818187c2f2ef6 schema:name Jaime E. Villegas
    119 rdf:type schema:Person
    120 N81833844d6cf4175b437f71ad9f3f82a schema:name Springer Nature - SN SciGraph project
    121 rdf:type schema:Organization
    122 N83a67f5e17984b6883a3abdf9ab7353a rdf:first Nd707f56355ef44c4a5fae72319fea22f
    123 rdf:rest rdf:nil
    124 Na39ff961c2184a8986093f40d71f6f4a schema:name Luis O. Burzio
    125 rdf:type schema:Person
    126 Nb8f539e3efee486ab76b81804cc8cff1 rdf:first N67a4b276ffcd45ccab0818187c2f2ef6
    127 rdf:rest N83a67f5e17984b6883a3abdf9ab7353a
    128 Nd707f56355ef44c4a5fae72319fea22f schema:name Veronica A. Burzio
    129 rdf:type schema:Person
    130 Nd7ad5c8ef70442a8a6faa96c2245c933 rdf:first Na39ff961c2184a8986093f40d71f6f4a
    131 rdf:rest Nb8f539e3efee486ab76b81804cc8cff1
    132 anzsrc-for:2581 schema:inDefinedTermSet anzsrc-for:
    133 rdf:type schema:DefinedTerm
    134 anzsrc-for:3142 schema:inDefinedTermSet anzsrc-for:
    135 rdf:type schema:DefinedTerm
    136 sg:pub.10.1007/bf03402027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075191622
    137 https://doi.org/10.1007/bf03402027
    138 rdf:type schema:CreativeWork
    139 sg:pub.10.1007/s00335-002-2218-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1032289892
    140 https://doi.org/10.1007/s00335-002-2218-z
    141 rdf:type schema:CreativeWork
    142 sg:pub.10.1038/216652a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053544698
    143 https://doi.org/10.1038/216652a0
    144 rdf:type schema:CreativeWork
    145 sg:pub.10.1038/290304a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038808547
    146 https://doi.org/10.1038/290304a0
    147 rdf:type schema:CreativeWork
    148 sg:pub.10.1038/296039a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015256219
    149 https://doi.org/10.1038/296039a0
    150 rdf:type schema:CreativeWork
    151 sg:pub.10.1038/35037728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022325441
    152 https://doi.org/10.1038/35037728
    153 rdf:type schema:CreativeWork
    154 sg:pub.10.1038/35037734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040101069
    155 https://doi.org/10.1038/35037734
    156 rdf:type schema:CreativeWork
    157 sg:pub.10.1038/35042675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023763406
    158 https://doi.org/10.1038/35042675
    159 rdf:type schema:CreativeWork
    160 sg:pub.10.1038/35078107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028423924
    161 https://doi.org/10.1038/35078107
    162 rdf:type schema:CreativeWork
    163 sg:pub.10.1038/35083620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009664464
    164 https://doi.org/10.1038/35083620
    165 rdf:type schema:CreativeWork
    166 sg:pub.10.1038/365566a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004328835
    167 https://doi.org/10.1038/365566a0
    168 rdf:type schema:CreativeWork
    169 sg:pub.10.1038/75007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024503242
    170 https://doi.org/10.1038/75007
    171 rdf:type schema:CreativeWork
    172 sg:pub.10.1038/nature03121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043296399
    173 https://doi.org/10.1038/nature03121
    174 rdf:type schema:CreativeWork
    175 sg:pub.10.1038/nbt764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023895188
    176 https://doi.org/10.1038/nbt764
    177 rdf:type schema:CreativeWork
    178 sg:pub.10.1038/nbt915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003713111
    179 https://doi.org/10.1038/nbt915
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1038/ncb0901-839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036269889
    182 https://doi.org/10.1038/ncb0901-839
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1038/ncb1101-e255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036625499
    185 https://doi.org/10.1038/ncb1101-e255
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1038/ng909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016341645
    188 https://doi.org/10.1038/ng909
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1038/ng944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042354461
    191 https://doi.org/10.1038/ng944
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1038/nm1164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051572486
    194 https://doi.org/10.1038/nm1164
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/nrg908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003050911
    197 https://doi.org/10.1038/nrg908
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/sj.onc.1207512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019973027
    200 https://doi.org/10.1038/sj.onc.1207512
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.1002/j.1460-2075.1984.tb01974.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1081559826
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.1016/0092-8674(80)90555-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052344297
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.1016/0378-1119(89)90028-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000640149
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.1016/0968-0896(95)00171-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041892923
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1016/j.bbrc.2003.08.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016995374
    211 rdf:type schema:CreativeWork
    212 https://doi.org/10.1016/s0005-2728(98)00161-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034650442
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1016/s0006-291x(03)00630-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046627049
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1016/s0167-4781(99)00150-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042006194
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1016/s0378-1119(00)00224-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002450910
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1016/s0958-1669(97)80008-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000332835
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1016/s0960-9822(00)00106-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049321303
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1016/s1097-2765(01)00341-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009904849
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1016/s1357-4310(00)01805-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000062054
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1016/s1386-6532(02)00234-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051430425
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1016/s1525-0016(03)00244-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026323120
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1021/bi00245a001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055166843
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1046/j.0956-5507.2003.00090.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042292798
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1073/pnas.0235524100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007256345
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1073/pnas.0402630101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043067468
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1073/pnas.0903086106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049581730
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1073/pnas.171251798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017733703
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1073/pnas.62.4.1077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040289760
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1073/pnas.78.3.1441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012274586
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1073/pnas.95.19.11274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001260347
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1073/pnas.97.10.5633 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036956205
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1074/jbc.273.49.32608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010114830
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1074/jbc.274.3.1715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037046577
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1074/jbc.274.30.20855 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041778391
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1074/jbc.274.9.5953 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005593721
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1074/jbc.275.12.8461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027290425
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1074/jbc.m107206200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035049705
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1074/jbc.m108844200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039717734
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1074/jbc.m109784200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041697993
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1074/jbc.m208766200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020523792
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1074/jbc.m210326200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014989445
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1074/jbc.m301392200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042857775
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1084/jem.184.2.747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003146420
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1084/jem.189.5.821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019798068
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1084/jem.191.7.1095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016781884
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1089/104454900439809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059203577
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1089/154545703322617078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059216015
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1093/hmg/6.4.615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001640695
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1093/humrep/15.suppl_2.11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020870698
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1093/molehr/8.11.977 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004816542
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1093/nar/19.7.1437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034993468
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1093/nar/28.11.2242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041873408
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1093/nar/28.9.e40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038384204
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1093/nar/30.9.1895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043940343
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1093/nar/gkf598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035615795
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1093/nar/gkg185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028892999
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1093/nar/gkg409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033210251
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1093/nar/gkh220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022828371
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1126/science.123.3191.309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062467291
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1126/science.2035027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062519239
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1126/science.275.5302.967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062555784
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1126/science.285.5434.1733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062566572
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1126/science.6200938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062635713
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1128/jvi.74.19.8793-8802.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029628199
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1128/mcb.22.4.1116-1125.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049392410
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1200/jco.1999.17.9.2941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074549931
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1517/17425247.2.1.3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034720714
    323 rdf:type schema:CreativeWork
     




    Preview window. Press ESC to close (or click here)


    ...