Methods for multi-resolution analysis of cell-free nucleic acids


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Darya Chudova , Helmy Eltoukhy , Stefanie Ann Ward MORTIMER , Diana Abdueva

ABSTRACT

The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample. These bait set panels can selectively enrich for one or more nucleosome-associated regions of a genome, said nucleosome-associated regions comprising genomic regions having one or more genomic base positions with differential nucleosomal occupancy, wherein the differential nucleosomal occupancy is characteristic of a cell or tissue type of origin or disease state. More... »

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