Methods for nucleic acid editing


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

David R. Liu , Alexis Christine Komor

ABSTRACT

Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. In some embodiments, fusion proteins of Cas9 and nucleic acid editing enzymes or enzyme domains, e.g., deaminase domains, are provided. In some embodiments, methods for targeted nucleic acid editing are provided. In some embodiments, reagents and kits for the generation of targeted nucleic acid editing proteins, e.g., fusion proteins of Cas9 and nucleic acid editing enzymes or domains, are provided. More... »

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    Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. In some embodiments, fusion proteins of Cas9 and nucleic acid editing enzymes or enzyme domains, e.g., deaminase domains, are provided. In some embodiments, methods for targeted nucleic acid editing are provided. In some embodiments, reagents and kits for the generation of targeted nucleic acid editing proteins, e.g., fusion proteins of Cas9 and nucleic acid editing enzymes or domains, are provided.

    ", "id": "sg:patent.US-9840699-B2", "keywords": [ "method", "nucleic acid", "aspect", "disclosure", "reagent", "kit", "single site", "genome", "cell", "human genome", "embodiment", "fusion protein", "editing enzyme", "enzyme", "deaminase", "generation", "domain" ], "name": "Methods for nucleic acid editing", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.38142.3c", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-9840699-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-03-07T15:34", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com.uberresearch.data.dev.patents-pipeline/full_run_10/sn-export/5eb3e5a348d7f117b22cc85fb0b02730/0000100128-0000348334/json_export_962f20a5.jsonl", "type": "Patent" } ]
     

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