Imaging a target fluorophore in a biological material in the presence of autofluorescence


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Eduardo Hiroyuki MORIYAMA , Chun Ho SZE

ABSTRACT

Methods and systems are disclosed for extracting an image of a target fluorophore in a biological material, which involve inducing both autofluorescence of the biological material and fluorescence of the fluorophore, acquiring an image arising from both the autofluorescence of the biological material and the fluorophore, and an image arising only from the autofluorescence, subtracting the two images to produce an image representing only the fluorophore, wherein relative intensities of the excitation light used to induce the autofluorescence and the fluorescence are modulated prior to acquiring the images. More... »

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    Methods and systems are disclosed for extracting an image of a target fluorophore in a biological material, which involve inducing both autofluorescence of the biological material and fluorescence of the fluorophore, acquiring an image arising from both the autofluorescence of the biological material and the fluorophore, and an image arising only from the autofluorescence, subtracting the two images to produce an image representing only the fluorophore, wherein relative intensities of the excitation light used to induce the autofluorescence and the fluorescence are modulated prior to acquiring the images.

    ", "id": "sg:patent.US-9816930-B2", "keywords": [ "imaging", "fluorophores", "biological material", "autofluorescence", "method", "fluorescence", "relative intensity", "excitation light" ], "name": "Imaging a target fluorophore in a biological material in the presence of autofluorescence", "sameAs": [ "https://app.dimensions.ai/details/patent/US-9816930-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-03-07T15:31", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com.uberresearch.data.dev.patents-pipeline/full_run_10/sn-export/5eb3e5a348d7f117b22cc85fb0b02730/0000100128-0000348334/json_export_0db08f31.jsonl", "type": "Patent" } ]
     

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