Bone tissue engineering by ex vivo stem cells ongrowth into three-dimensional trabecular metal


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Zou Xuenong , Haisheng Li , Cody Bunger

ABSTRACT

Adult autologous stem cells cultured on a porous, three-dimensional tissue scaffold-implant for bone regeneration by the use of a hyaluronan and/or dexamethasone to accelerate bone healing alone or in combination with recombinant growth factors or transfected osteogenic genes. The scaffold-implant may be machined into a custom-shaped three-dimensional cell culture system for support of cell growth, reservoir for peptides, recombinant growth factors, cytokines and antineoplastic drugs in the presence of a hyaluronan and/or dexamethasone alone or in combination with growth factors or transfected osteogenic genes, to be assembled ex vivo in a tissue incubator for implantation into bone tissue. More... »

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