Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

James M. Wilson , Anna Tretiakova

ABSTRACT

Described herein are synonymously altered gene sequences which express protein in differing levels within secretory as compared to non-secretory target tissue. An expression cassette comprising an open reading frame (ORF) for a protein under the control of regulatory sequences which direct expression of the product in cell, which ORF has been modified to preferentially increase expression levels in a selected tissue, wherein the modified ORF is characterized by a triplet frequency of any one of Tables 3-12, 16 or 17. More... »

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