Use of ICOS-based CARs to enhance antitumor activity and CAR persistence


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Carl H. June , Sonia Guedan Carrio , Yangbing Zhao , John Scholler

ABSTRACT

The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a genetically modified Th17 cell to express a CAR having an antigen binding domain, a transmembrane domain, and an ICOS intracellular signaling domain.

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