Methods for sequencing a biomolecule by detecting relative positions of hybridized probes


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Peter H. Goldstein

ABSTRACT

A sequencing method is presented in which a biomolecule is hybridized with a specially chosen pool of different probes of known sequence which can be electrically distinguished. The different probe types are tagged such that they can be distinguished from each other in a Hybridization Assisted Nanopore Sequencing (HANS) detection system, and their relative positions on the biomolecule can be determined as the biomolecule passes through a pore or channel. The methods eliminate, resolve, or greatly reduce ambiguities encountered in previous sequencing methods. More... »

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