Methods for the production of IPS cells using Epstein-Barr (EBV)-based reprogramming vectors


Ontology type: sgo:Patent     


Patent Info

DATE

2017-05-09T00:00

AUTHORS

Amanda Mack

ABSTRACT

Methods and composition of induction of pluripotent stem cells and other desired cell types are disclosed. For example, in certain aspects methods for generating essentially vector-free induced pluripotent stem cells are described. Furthermore, the invention provides induced pluripotent stem cells and desired cell types essentially free of exogenous vector elements with the episomal expression vectors to express differentiation programming factors. More... »

Related SciGraph Publications

  • 2009-03. Generation of iPS cells using defined factors linked via the self-cleaving 2A sequences in a single open reading frame in CELL RESEARCH
  • 2008-07. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds in NATURE BIOTECHNOLOGY
  • 2006-12. Cell fusion for reprogramming pluripotency in STEM CELL REVIEWS AND REPORTS
  • 1985-02. Stable replication of plasmids derived from Epstein–Barr virus in various mammalian cells in NATURE
  • 2007-07. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state in NATURE
  • 2008-08. A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types in NATURE BIOTECHNOLOGY
  • 2003-03. Homologous recombination in human embryonic stem cells in NATURE BIOTECHNOLOGY
  • 2007-07. Generation of germline-competent induced pluripotent stem cells in NATURE
  • 2008-01. Reprogramming of human somatic cells to pluripotency with defined factors in NATURE
  • 2007-10. Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells in NATURE BIOTECHNOLOGY
  • 2009-04. piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells in NATURE
  • 2008-07. Mediators of reprogramming: transcription factors and transitions through mitosis in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2007-03. Nonviral gene delivery: What we know and what is next in THE AAPS JOURNAL
  • 2008-01. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts in NATURE BIOTECHNOLOGY
  • 1998-01. Repeat-induced gene silencing in mammals in NATURE GENETICS
  • 2004-12. Gene Therapy Progress and Prospects: Episomally maintained self-replicating systems in GENE THERAPY
  • 2010-03. A nonviral minicircle vector for deriving human iPS cells in NATURE METHODS
  • 2008-07. Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors in NATURE
  • 2007-06-07. Developmental reprogramming after chromosome transfer into mitotic mouse zygotes in NATURE
  • 2006-12. Cellular reprogramming for the creation of patient-specific embryonic stem cells in STEM CELL REVIEWS AND REPORTS
  • 2006-02. Derivation of human embryonic stem cells in defined conditions in NATURE BIOTECHNOLOGY
  • 2008-05. Enhanced efficiency of generating induced pluripotent stem (iPS) cells from human somatic cells by a combination of six transcription factors in CELL RESEARCH
  • 2006-06. Nanog promotes transfer of pluripotency after cell fusion in NATURE
  • 2006-08. Dissecting self-renewal in stem cells with RNA interference in NATURE
  • 2008-07-03. Dissecting direct reprogramming through integrative genomic analysis in NATURE
  • 2008-07. Generation of human-induced pluripotent stem cells in NATURE PROTOCOLS
  • 2006-08. Feeder-independent culture of human embryonic stem cells in NATURE METHODS
  • 2009-04. Virus-free induction of pluripotency and subsequent excision of reprogramming factors in NATURE
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2995", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "name": "Amanda Mack", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1091/mbc.e05-06-0572", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000015217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1152092", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000037346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04914", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001794355", 
              "https://doi.org/10.1038/nature04914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04914", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001794355", 
              "https://doi.org/10.1038/nature04914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04914", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001794355", 
              "https://doi.org/10.1038/nature04914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2009.20", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002077212", 
              "https://doi.org/10.1038/cr.2009.20"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07864", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002136274", 
              "https://doi.org/10.1038/nature07864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05934", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002347899", 
              "https://doi.org/10.1038/nature05934"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1208/aapsj0901009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002409643", 
              "https://doi.org/10.1208/aapsj0901009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1374", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002744128", 
              "https://doi.org/10.1038/nbt1374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000096508", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003726810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2008.92", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003864180", 
              "https://doi.org/10.1038/nprot.2008.92"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05879", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003888215", 
              "https://doi.org/10.1038/nature05879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1483", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004160248", 
              "https://doi.org/10.1038/nbt1483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0604938103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004244324"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.03.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004352286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.03.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004352286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.03147-12", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004617240"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(03)00392-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004929245"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2008.05.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006466689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2008.05.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006466689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0027956", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007287566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/27.7.1674", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007796086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2008.02.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008490443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2008.02.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008490443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1432-1327.2000.01645.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009885282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.11.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010904856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.11.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010904856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81769-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011032363"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2007.08.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011219533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2007.08.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011219533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/stemcells.2005-0292", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011281633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/stemcells.2005-0292", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011281633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/stemcells.2005-0338", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011768173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/stemcells.2005-0338", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011768173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06534", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011992920", 
              "https://doi.org/10.1038/nature06534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.4.8.1551", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012247976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2007.12.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012875023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2007.12.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012875023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt788", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013128911", 
              "https://doi.org/10.1038/nbt788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt788", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013128911", 
              "https://doi.org/10.1038/nbt788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0896-6273(03)00497-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013836053"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1418", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014318073", 
              "https://doi.org/10.1038/nbt1418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.07.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014573758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.07.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014573758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymthe.2006.03.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016041347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1440-169x.1999.00474.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016512196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.8.4084", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017634953"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07061", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017686107", 
              "https://doi.org/10.1038/nature07061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1067081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018333078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/excr.1998.4272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018588845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05944", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019109862", 
              "https://doi.org/10.1038/nature05944"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1426", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019714920", 
              "https://doi.org/10.1038/nmeth.1426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1426", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019714920", 
              "https://doi.org/10.1038/nmeth.1426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019814710", 
              "https://doi.org/10.1038/nmeth902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019814710", 
              "https://doi.org/10.1038/nmeth902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07863", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019816783", 
              "https://doi.org/10.1038/nature07863"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/stem.39", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020054873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.81.12.3806", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020869638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/313812a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021158149", 
              "https://doi.org/10.1038/313812a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1162494", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021871278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2006.08.175", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021964234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.224503", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023512263"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/abbs/37.1.68", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023545608"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0811426106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024424498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0711983105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024490582"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.93.21.11371", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025347934"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/27.2.426", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026370844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.282.5391.1145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028898955"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7601853", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028907061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2008.51", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029601830", 
              "https://doi.org/10.1038/cr.2008.51"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2007.05.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029649252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2007.05.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029649252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.98.4.1865", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029792657"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030407065", 
              "https://doi.org/10.1038/nbt1177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030407065", 
              "https://doi.org/10.1038/nbt1177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/rep.1.01077", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030980657"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0955-0674(93)90077-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031898558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1116447", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032194044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.12.8.3636", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033637717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.scr.2008.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035989845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.scr.2008.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035989845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0401355101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036358425"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/stemcells.22-1-51", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036526675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2004-04-1649", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037158040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037743725", 
              "https://doi.org/10.1038/nature07056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0198-56", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039448670", 
              "https://doi.org/10.1038/ng0198-56"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.78.21.11487-11505.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039569796"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.2336099100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040171084"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/sqb.2008.73.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040400361"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(85)90109-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040834013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1154884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041856503"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0026592", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042531215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04915", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042927160", 
              "https://doi.org/10.1038/nature04915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04915", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042927160", 
              "https://doi.org/10.1038/nature04915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04915", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042927160", 
              "https://doi.org/10.1038/nature04915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04915", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042927160", 
              "https://doi.org/10.1038/nature04915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7600029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043069490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02698060", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043335065", 
              "https://doi.org/10.1007/bf02698060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02698060", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043335065", 
              "https://doi.org/10.1007/bf02698060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02698055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043559383", 
              "https://doi.org/10.1007/bf02698055"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02698055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043559383", 
              "https://doi.org/10.1007/bf02698055"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/dvg.20338", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043567132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.5.2509", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044133693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1172482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044377678"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0904825106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045086889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.20.18.6768-6778.2000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045499889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.07.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047970638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.07.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047970638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1151526", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048905674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/stemcells.2008-0346", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049581519"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.08.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049638413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.08.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049638413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.08.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049638413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.050586197", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049736255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1335", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049953935", 
              "https://doi.org/10.1038/nbt1335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/stemcells.2008-1075", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049957596"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2439", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051604438", 
              "https://doi.org/10.1038/nrm2439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051703341", 
              "https://doi.org/10.1038/sj.gt.3302362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051703341", 
              "https://doi.org/10.1038/sj.gt.3302362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.415007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051984210"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0605985103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052329995"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jbiotec.2005.03.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052696659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jbiotec.2005.03.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052696659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2008.01.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053248333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2008.01.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053248333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/dbio.2000.9912", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053693663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi992957o", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055219100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi992957o", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055219100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/scd.2004.13.636", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059309426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1099/vir.0.80620-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060400630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1164270", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062458687"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.841339", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062655476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1987.tb04737.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079834161"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-05-09T00:00", 
        "description": "

    Methods and composition of induction of pluripotent stem cells and other desired cell types are disclosed. For example, in certain aspects methods for generating essentially vector-free induced pluripotent stem cells are described. Furthermore, the invention provides induced pluripotent stem cells and desired cell types essentially free of exogenous vector elements with the episomal expression vectors to express differentiation programming factors.

    ", "id": "sg:patent.US-9644184-B2", "keywords": [ "method", "induced pluripotent stem cell", "Human Herpesvirus 4", "reprogramming", "composition", "induction", "pluripotent stem cell", "desired cell type", "certain aspect", "invention", "element", "expression vector", "programming" ], "name": "Methods for the production of IPS cells using Epstein-Barr (EBV)-based reprogramming vectors", "sameAs": [ "https://app.dimensions.ai/details/patent/US-9644184-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:19", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_01458.jsonl", "type": "Patent" } ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-9644184-B2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-9644184-B2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-9644184-B2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-9644184-B2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    376 TRIPLES      14 PREDICATES      131 URIs      21 LITERALS      2 BLANK NODES

    Subject Predicate Object
    1 sg:patent.US-9644184-B2 schema:about anzsrc-for:2995
    2 schema:author Nb255670cb71445699952c2543ad9409e
    3 schema:citation sg:pub.10.1007/bf02698055
    4 sg:pub.10.1007/bf02698060
    5 sg:pub.10.1038/313812a0
    6 sg:pub.10.1038/cr.2008.51
    7 sg:pub.10.1038/cr.2009.20
    8 sg:pub.10.1038/nature04914
    9 sg:pub.10.1038/nature04915
    10 sg:pub.10.1038/nature05879
    11 sg:pub.10.1038/nature05934
    12 sg:pub.10.1038/nature05944
    13 sg:pub.10.1038/nature06534
    14 sg:pub.10.1038/nature07056
    15 sg:pub.10.1038/nature07061
    16 sg:pub.10.1038/nature07863
    17 sg:pub.10.1038/nature07864
    18 sg:pub.10.1038/nbt1177
    19 sg:pub.10.1038/nbt1335
    20 sg:pub.10.1038/nbt1374
    21 sg:pub.10.1038/nbt1418
    22 sg:pub.10.1038/nbt1483
    23 sg:pub.10.1038/nbt788
    24 sg:pub.10.1038/ng0198-56
    25 sg:pub.10.1038/nmeth.1426
    26 sg:pub.10.1038/nmeth902
    27 sg:pub.10.1038/nprot.2008.92
    28 sg:pub.10.1038/nrm2439
    29 sg:pub.10.1038/sj.gt.3302362
    30 sg:pub.10.1208/aapsj0901009
    31 https://doi.org/10.1002/dvg.20338
    32 https://doi.org/10.1002/j.1460-2075.1987.tb04737.x
    33 https://doi.org/10.1002/stem.39
    34 https://doi.org/10.1006/dbio.2000.9912
    35 https://doi.org/10.1006/excr.1998.4272
    36 https://doi.org/10.1016/0092-8674(85)90109-6
    37 https://doi.org/10.1016/0955-0674(93)90077-4
    38 https://doi.org/10.1016/j.bbrc.2006.08.175
    39 https://doi.org/10.1016/j.cell.2005.08.020
    40 https://doi.org/10.1016/j.cell.2006.07.024
    41 https://doi.org/10.1016/j.cell.2007.11.019
    42 https://doi.org/10.1016/j.cell.2008.03.028
    43 https://doi.org/10.1016/j.cell.2008.07.041
    44 https://doi.org/10.1016/j.jbiotec.2005.03.025
    45 https://doi.org/10.1016/j.scr.2008.01.001
    46 https://doi.org/10.1016/j.stem.2007.05.014
    47 https://doi.org/10.1016/j.stem.2007.08.008
    48 https://doi.org/10.1016/j.stem.2007.12.001
    49 https://doi.org/10.1016/j.stem.2008.01.004
    50 https://doi.org/10.1016/j.stem.2008.02.001
    51 https://doi.org/10.1016/j.stem.2008.05.011
    52 https://doi.org/10.1016/j.ymthe.2006.03.026
    53 https://doi.org/10.1016/s0092-8674(00)81769-9
    54 https://doi.org/10.1016/s0092-8674(03)00392-1
    55 https://doi.org/10.1016/s0896-6273(03)00497-5
    56 https://doi.org/10.1021/bi992957o
    57 https://doi.org/10.1038/sj.emboj.7600029
    58 https://doi.org/10.1038/sj.emboj.7601853
    59 https://doi.org/10.1046/j.1432-1327.2000.01645.x
    60 https://doi.org/10.1046/j.1440-169x.1999.00474.x
    61 https://doi.org/10.1073/pnas.0401355101
    62 https://doi.org/10.1073/pnas.050586197
    63 https://doi.org/10.1073/pnas.0604938103
    64 https://doi.org/10.1073/pnas.0605985103
    65 https://doi.org/10.1073/pnas.0711983105
    66 https://doi.org/10.1073/pnas.0811426106
    67 https://doi.org/10.1073/pnas.0904825106
    68 https://doi.org/10.1073/pnas.2336099100
    69 https://doi.org/10.1073/pnas.81.12.3806
    70 https://doi.org/10.1073/pnas.93.21.11371
    71 https://doi.org/10.1073/pnas.95.5.2509
    72 https://doi.org/10.1073/pnas.95.8.4084
    73 https://doi.org/10.1073/pnas.98.4.1865
    74 https://doi.org/10.1089/scd.2004.13.636
    75 https://doi.org/10.1091/mbc.e05-06-0572
    76 https://doi.org/10.1093/abbs/37.1.68
    77 https://doi.org/10.1093/nar/27.2.426
    78 https://doi.org/10.1093/nar/27.7.1674
    79 https://doi.org/10.1099/vir.0.80620-0
    80 https://doi.org/10.1101/gad.224503
    81 https://doi.org/10.1101/gad.415007
    82 https://doi.org/10.1101/sqb.2008.73.025
    83 https://doi.org/10.1126/science.1067081
    84 https://doi.org/10.1126/science.1116447
    85 https://doi.org/10.1126/science.1151526
    86 https://doi.org/10.1126/science.1152092
    87 https://doi.org/10.1126/science.1154884
    88 https://doi.org/10.1126/science.1162494
    89 https://doi.org/10.1126/science.1164270
    90 https://doi.org/10.1126/science.1172482
    91 https://doi.org/10.1126/science.282.5391.1145
    92 https://doi.org/10.1126/science.841339
    93 https://doi.org/10.1128/jvi.03147-12
    94 https://doi.org/10.1128/jvi.78.21.11487-11505.2004
    95 https://doi.org/10.1128/mcb.12.8.3636
    96 https://doi.org/10.1128/mcb.20.18.6768-6778.2000
    97 https://doi.org/10.1128/mcb.4.8.1551
    98 https://doi.org/10.1159/000096508
    99 https://doi.org/10.1182/blood-2004-04-1649
    100 https://doi.org/10.1371/journal.pone.0026592
    101 https://doi.org/10.1371/journal.pone.0027956
    102 https://doi.org/10.1530/rep.1.01077
    103 https://doi.org/10.1634/stemcells.2005-0292
    104 https://doi.org/10.1634/stemcells.2005-0338
    105 https://doi.org/10.1634/stemcells.2008-0346
    106 https://doi.org/10.1634/stemcells.2008-1075
    107 https://doi.org/10.1634/stemcells.22-1-51
    108 schema:datePublished 2017-05-09T00:00
    109 schema:description <p id="p-0001" num="0000">Methods and composition of induction of pluripotent stem cells and other desired cell types are disclosed. For example, in certain aspects methods for generating essentially vector-free induced pluripotent stem cells are described. Furthermore, the invention provides induced pluripotent stem cells and desired cell types essentially free of exogenous vector elements with the episomal expression vectors to express differentiation programming factors.</p>
    110 schema:keywords Human Herpesvirus 4
    111 certain aspect
    112 composition
    113 desired cell type
    114 element
    115 expression vector
    116 induced pluripotent stem cell
    117 induction
    118 invention
    119 method
    120 pluripotent stem cell
    121 programming
    122 reprogramming
    123 schema:name Methods for the production of IPS cells using Epstein-Barr (EBV)-based reprogramming vectors
    124 schema:sameAs https://app.dimensions.ai/details/patent/US-9644184-B2
    125 schema:sdDatePublished 2019-04-18T10:19
    126 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    127 schema:sdPublisher Nc93ae44d940c4812a12d1d600f42061d
    128 sgo:license sg:explorer/license/
    129 sgo:sdDataset patents
    130 rdf:type sgo:Patent
    131 N5ab52a37c089497fad58e31dd4ba293d schema:name Amanda Mack
    132 rdf:type schema:Person
    133 Nb255670cb71445699952c2543ad9409e rdf:first N5ab52a37c089497fad58e31dd4ba293d
    134 rdf:rest rdf:nil
    135 Nc93ae44d940c4812a12d1d600f42061d schema:name Springer Nature - SN SciGraph project
    136 rdf:type schema:Organization
    137 anzsrc-for:2995 schema:inDefinedTermSet anzsrc-for:
    138 rdf:type schema:DefinedTerm
    139 sg:pub.10.1007/bf02698055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043559383
    140 https://doi.org/10.1007/bf02698055
    141 rdf:type schema:CreativeWork
    142 sg:pub.10.1007/bf02698060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043335065
    143 https://doi.org/10.1007/bf02698060
    144 rdf:type schema:CreativeWork
    145 sg:pub.10.1038/313812a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021158149
    146 https://doi.org/10.1038/313812a0
    147 rdf:type schema:CreativeWork
    148 sg:pub.10.1038/cr.2008.51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029601830
    149 https://doi.org/10.1038/cr.2008.51
    150 rdf:type schema:CreativeWork
    151 sg:pub.10.1038/cr.2009.20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002077212
    152 https://doi.org/10.1038/cr.2009.20
    153 rdf:type schema:CreativeWork
    154 sg:pub.10.1038/nature04914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001794355
    155 https://doi.org/10.1038/nature04914
    156 rdf:type schema:CreativeWork
    157 sg:pub.10.1038/nature04915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042927160
    158 https://doi.org/10.1038/nature04915
    159 rdf:type schema:CreativeWork
    160 sg:pub.10.1038/nature05879 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003888215
    161 https://doi.org/10.1038/nature05879
    162 rdf:type schema:CreativeWork
    163 sg:pub.10.1038/nature05934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002347899
    164 https://doi.org/10.1038/nature05934
    165 rdf:type schema:CreativeWork
    166 sg:pub.10.1038/nature05944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019109862
    167 https://doi.org/10.1038/nature05944
    168 rdf:type schema:CreativeWork
    169 sg:pub.10.1038/nature06534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011992920
    170 https://doi.org/10.1038/nature06534
    171 rdf:type schema:CreativeWork
    172 sg:pub.10.1038/nature07056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037743725
    173 https://doi.org/10.1038/nature07056
    174 rdf:type schema:CreativeWork
    175 sg:pub.10.1038/nature07061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017686107
    176 https://doi.org/10.1038/nature07061
    177 rdf:type schema:CreativeWork
    178 sg:pub.10.1038/nature07863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019816783
    179 https://doi.org/10.1038/nature07863
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1038/nature07864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002136274
    182 https://doi.org/10.1038/nature07864
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1038/nbt1177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030407065
    185 https://doi.org/10.1038/nbt1177
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1038/nbt1335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049953935
    188 https://doi.org/10.1038/nbt1335
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1038/nbt1374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002744128
    191 https://doi.org/10.1038/nbt1374
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1038/nbt1418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014318073
    194 https://doi.org/10.1038/nbt1418
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/nbt1483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004160248
    197 https://doi.org/10.1038/nbt1483
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/nbt788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013128911
    200 https://doi.org/10.1038/nbt788
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/ng0198-56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039448670
    203 https://doi.org/10.1038/ng0198-56
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/nmeth.1426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019714920
    206 https://doi.org/10.1038/nmeth.1426
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/nmeth902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019814710
    209 https://doi.org/10.1038/nmeth902
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/nprot.2008.92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003864180
    212 https://doi.org/10.1038/nprot.2008.92
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1038/nrm2439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051604438
    215 https://doi.org/10.1038/nrm2439
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1038/sj.gt.3302362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051703341
    218 https://doi.org/10.1038/sj.gt.3302362
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1208/aapsj0901009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002409643
    221 https://doi.org/10.1208/aapsj0901009
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1002/dvg.20338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043567132
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1002/j.1460-2075.1987.tb04737.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1079834161
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1002/stem.39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020054873
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1006/dbio.2000.9912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053693663
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1006/excr.1998.4272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018588845
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1016/0092-8674(85)90109-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040834013
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1016/0955-0674(93)90077-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031898558
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1016/j.bbrc.2006.08.175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021964234
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1016/j.cell.2005.08.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049638413
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1016/j.cell.2006.07.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014573758
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1016/j.cell.2007.11.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010904856
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1016/j.cell.2008.03.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004352286
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1016/j.cell.2008.07.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047970638
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1016/j.jbiotec.2005.03.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052696659
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1016/j.scr.2008.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035989845
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1016/j.stem.2007.05.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029649252
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1016/j.stem.2007.08.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011219533
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1016/j.stem.2007.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012875023
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1016/j.stem.2008.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053248333
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1016/j.stem.2008.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008490443
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1016/j.stem.2008.05.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006466689
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1016/j.ymthe.2006.03.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016041347
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1016/s0092-8674(00)81769-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011032363
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/s0092-8674(03)00392-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004929245
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1016/s0896-6273(03)00497-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013836053
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1021/bi992957o schema:sameAs https://app.dimensions.ai/details/publication/pub.1055219100
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1038/sj.emboj.7600029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043069490
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1038/sj.emboj.7601853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028907061
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1046/j.1432-1327.2000.01645.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009885282
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1046/j.1440-169x.1999.00474.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016512196
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1073/pnas.0401355101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036358425
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1073/pnas.050586197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049736255
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1073/pnas.0604938103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004244324
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1073/pnas.0605985103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052329995
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1073/pnas.0711983105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024490582
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1073/pnas.0811426106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024424498
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1073/pnas.0904825106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045086889
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1073/pnas.2336099100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040171084
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1073/pnas.81.12.3806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020869638
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1073/pnas.93.21.11371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025347934
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1073/pnas.95.5.2509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044133693
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1073/pnas.95.8.4084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017634953
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1073/pnas.98.4.1865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029792657
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1089/scd.2004.13.636 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059309426
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1091/mbc.e05-06-0572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000015217
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1093/abbs/37.1.68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023545608
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1093/nar/27.2.426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026370844
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1093/nar/27.7.1674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007796086
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1099/vir.0.80620-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060400630
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1101/gad.224503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023512263
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1101/gad.415007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051984210
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1101/sqb.2008.73.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040400361
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1126/science.1067081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018333078
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1126/science.1116447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032194044
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1126/science.1151526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048905674
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1126/science.1152092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000037346
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1126/science.1154884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041856503
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1126/science.1162494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021871278
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1126/science.1164270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062458687
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1126/science.1172482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044377678
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1126/science.282.5391.1145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028898955
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1126/science.841339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062655476
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1128/jvi.03147-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004617240
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1128/jvi.78.21.11487-11505.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039569796
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1128/mcb.12.8.3636 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033637717
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1128/mcb.20.18.6768-6778.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045499889
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1128/mcb.4.8.1551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012247976
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1159/000096508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003726810
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1182/blood-2004-04-1649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037158040
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1371/journal.pone.0026592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042531215
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1371/journal.pone.0027956 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007287566
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1530/rep.1.01077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030980657
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1634/stemcells.2005-0292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011281633
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1634/stemcells.2005-0338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011768173
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1634/stemcells.2008-0346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049581519
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1634/stemcells.2008-1075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049957596
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1634/stemcells.22-1-51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036526675
    376 rdf:type schema:CreativeWork
     




    Preview window. Press ESC to close (or click here)


    ...