Substituted bicyclic compounds as bromodomain inhibitors


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Shuang Liu , John Frederick Quinn , Bryan Cordell Duffy , Ruifang Wang , May Xiaowu JIANG , Gregory Scott Martin , He Zhao , Michael Ellis , Gregory Steven Wagner , Peter Ronald Young

ABSTRACT

The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.

Related SciGraph Publications

  • 2011-04. The role of cytokines in Guillain–Barré syndrome in JOURNAL OF NEUROLOGY
  • 2013-02. Involvement of Interleukin-17A in Pancreatic Damage in Rat Experimental Acute Necrotizing Pancreatitis in INFLAMMATION
  • 2011-08. Epigenetic mechanisms in virus-induced tumorigenesis in CLINICAL EPIGENETICS
  • 2012-10. Increased serum interleukin-17 in Graves’ ophthalmopathy in GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
  • 2009-05. IL-17 disrupts corneal barrier following desiccating stress in MUCOSAL IMMUNOLOGY
  • 2012-02. Indium bromide catalysed, ultrasound-assisted, regio-selective synthesis of ethyl-5-(trifluoromethyl)-1-(3-substituted-isoquinolin-1-yl)-1H-pyrazole-4-carboxylates in RESEARCH ON CHEMICAL INTERMEDIATES
  • 2013-01. The Ex Vivo Production of IL-6 and IL-21 by CD4+ T Cells is Directly Associated with Neurological Disability in Neuromyelitis Optica Patients in JOURNAL OF CLINICAL IMMUNOLOGY
  • 2012-05. Aberrant epigenetic regulation of bromodomain Brd4 in human colon cancer in JOURNAL OF MOLECULAR MEDICINE
  • 2010-12. Selective inhibition of BET bromodomains in NATURE
  • 1998-08. Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis in NATURE
  • 2012-08. Evaluation of the T helper 17 axis in ankylosing spondylitis in RHEUMATOLOGY INTERNATIONAL
  • 2012-07. BET domain co-regulators in obesity, inflammation and cancer in NATURE REVIEWS CANCER
  • 2008-11. Profile of Th17 cytokines (IL-17, TGF-β, IL-6) and Th1 cytokine (IFN-γ) in patients with immune thrombocytopenic purpura in ANNALS OF HEMATOLOGY
  • 2011-09. The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy in CELL DEATH & DIFFERENTIATION
  • 2010-09. Recent advances in histone deacetylase targeted cancer therapy in SURGERY TODAY
  • 2013-05. Successful treatment with tocilizumab in a case of Cogan’s syndrome complicated with aortitis in MODERN RHEUMATOLOGY
  • 2004-04. Plasma cytokine levels predict mortality in patients with acute renal failure in KIDNEY INTERNATIONAL
  • 2007-01. Abrogation of signal-dependent activation of the cdk9/cyclin T2a complex in human RD rhabdomyosarcoma cells in CELL DEATH & DIFFERENTIATION
  • 2011-08. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma in NATURE
  • 2008-07. MYB function in normal and cancer cells in NATURE REVIEWS CANCER
  • 2011-10. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia in NATURE
  • 2012-10. Increased Pro-inflammatory Cytokine Production After Lipopolysaccharide Stimulation in Patients with X-linked Agammaglobulinemia in JOURNAL OF CLINICAL IMMUNOLOGY
  • 2011-10. Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia in NATURE
  • 2010-09. Involvement of IL-17F via the induction of IL-6 in psoriasis in ARCHIVES OF DERMATOLOGICAL RESEARCH
  • 2011-05. Novel HDL-directed pharmacotherapeutic strategies in NATURE REVIEWS CARDIOLOGY
  • 2009-09. Reduction of Interleukin-6, Interleukin-8, and Anti-Phosphatidylserine–Prothrombin Complex Antibody by Granulocyte and Monocyte Adsorption Apheresis in a Patient With Pyoderma Gangrenosum and Ulcerative Colitis in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2014-05. Targeting bromodomains: epigenetic readers of lysine acetylation in NATURE REVIEWS DRUG DISCOVERY
  • JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2464", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "name": "Shuang Liu", 
            "type": "Person"
          }, 
          {
            "name": "John Frederick Quinn", 
            "type": "Person"
          }, 
          {
            "name": "Bryan Cordell Duffy", 
            "type": "Person"
          }, 
          {
            "name": "Ruifang Wang", 
            "type": "Person"
          }, 
          {
            "name": "May Xiaowu JIANG", 
            "type": "Person"
          }, 
          {
            "name": "Gregory Scott Martin", 
            "type": "Person"
          }, 
          {
            "name": "He Zhao", 
            "type": "Person"
          }, 
          {
            "name": "Michael Ellis", 
            "type": "Person"
          }, 
          {
            "name": "Gregory Steven Wagner", 
            "type": "Person"
          }, 
          {
            "name": "Peter Ronald Young", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s10753-012-9519-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000105909", 
              "https://doi.org/10.1007/s10753-012-9519-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10753-012-9519-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000105909", 
              "https://doi.org/10.1007/s10753-012-9519-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1196/annals.1372.039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000129161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0023656", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000155499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00417-012-2092-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000193718", 
              "https://doi.org/10.1007/s00417-012-2092-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/rheumatology/keg459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000348279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1517/13543784.8.9.1327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000394176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1346-8138.1998.tb02375.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001138030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.004481", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001424180"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09504", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001851540", 
              "https://doi.org/10.1038/nature09504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0018909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002616102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmcl.2012.02.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002626433"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.192.6.899", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002841485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10875-012-9706-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003227365", 
              "https://doi.org/10.1007/s10875-012-9706-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2011.17", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003477526", 
              "https://doi.org/10.1038/cdd.2011.17"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaut.2012.07.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004684624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.06.045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004883182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2353/ajpath.2009.090319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005107085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/clp.10.37", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005849919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ibd.20148", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006405097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tips.2011.12.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006448003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00415-010-5836-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006471313", 
              "https://doi.org/10.1007/s00415-010-5836-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaut.2010.12.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006498064"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-4362.2001.01083.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007496941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2249.2009.03947.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007613291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.joca.2011.01.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008108537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.2008.07161.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008259678"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2249.2011.04510.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008703005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2230.2010.03972.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009161445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.mlg.0000161334.67977.5d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009886926"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13148-011-0026-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010293021", 
              "https://doi.org/10.1007/s13148-011-0026-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.02468-08", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010336351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.0000049742.68848.99", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011078906"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.193.6.713", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011193667"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/00365513.2011.652158", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011284973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1044-5323(02)00125-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011548907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00296-011-1995-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012271508", 
              "https://doi.org/10.1007/s00296-011-1995-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0056514", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012394551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.01316-08", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012491569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m112.413047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012692612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00277-008-0535-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012819123", 
              "https://doi.org/10.1007/s00277-008-0535-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00277-008-0535-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012819123", 
              "https://doi.org/10.1007/s00277-008-0535-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmcl.2012.01.125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013024286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2004.07.047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013250329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.109.872903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013624700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.19.6.1518", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013661868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2009.271", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014339508", 
              "https://doi.org/10.1038/ajg.2009.271"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.201040391", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014845015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1523-1755.2004.00512.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014853341", 
              "https://doi.org/10.1111/j.1523-1755.2004.00512.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm200640v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014962424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c2md20189e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015340401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1399-3038.2011.01198.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015419314"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00109-011-0837-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015571426", 
              "https://doi.org/10.1007/s00109-011-0837-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci115411", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016321463"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10875-012-9780-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017371763", 
              "https://doi.org/10.1007/s10875-012-9780-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/cyto.2002.1039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017471537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jpedsurg.2004.06.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017597625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0272-6386(95)90157-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018352557"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.25003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019537340"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10351", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019649945", 
              "https://doi.org/10.1038/nature10351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.02.8589", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020057203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/00207450903428970", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020096258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20090928", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021145702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.urology.2006.04.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021403224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/cvr/cvr148", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021560410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/theoncologist.2010-0212", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022108823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.0902-4441.2005.t01-1-ejh2437.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022212451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1601-0825.2005.01165.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022309784"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1755-148x.2009.00649.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023027036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11164-011-0360-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023757810", 
              "https://doi.org/10.1007/s11164-011-0360-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mi.2009.5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023802098", 
              "https://doi.org/10.1038/mi.2009.5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00595-010-4300-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024739436", 
              "https://doi.org/10.1007/s00595-010-4300-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm200108t", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025618144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.08.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026115083"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1586/eci.11.7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026560618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.semcancer.2006.07.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026605265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10509", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026728956", 
              "https://doi.org/10.1038/nature10509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/rheumatology/ken468", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027277171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1189/jlb.0312165", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027321056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gks976", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027886931"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m112.410746", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028060443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jmcb/mjr042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028673905"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030076294", 
              "https://doi.org/10.1038/nature10334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2010.05.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030271685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/theoncologist.5-suppl_1-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031700568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/09629350410001664789", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031710049"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00403-010-1033-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031744711", 
              "https://doi.org/10.1007/s00403-010-1033-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2008-08-172155", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031848248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja412434f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031849993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(00)80139-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031994520"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.21669", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032406417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/theoncologist.5-suppl_1-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032506924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.26.1347", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032892538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.exer.2010.04.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032933636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4402008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034892015", 
              "https://doi.org/10.1038/sj.cdd.4402008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000237257", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036213454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/rheumatology/ken349", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036238315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1440-1797.2010.01343.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036626853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1212264109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037215264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/29788", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037262209", 
              "https://doi.org/10.1038/29788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.exphem.2012.08.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037688825"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmcl.2010.07.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038018165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd4286", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038849480", 
              "https://doi.org/10.1038/nrd4286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2003-06-2116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039291918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-11-0220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039610161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajpath.2013.04.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040308342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.1588", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040719033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1108190108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041102152"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tips.2008.03.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042076553"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci115950", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042252284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0163-4453(98)91120-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043428808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ibd.20475", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043470749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2012-02-413021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043680109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.2005.079343", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043790509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.ppat.1002334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043816338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m112.359505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043907936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm301588r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044763054"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044768219", 
              "https://doi.org/10.1038/nrc3256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.00502-06", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044978788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijcard.2012.01.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046016453"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0005903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046254323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci5624", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046321148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/cs20080581", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046352368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1167/iovs.10-6272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047056364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/rheumatology/ken489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047619133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2169/internalmedicine.32.189", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048307603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/emboj.2012.233", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049083427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2249.2010.04236.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049628585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10165-012-0691-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049708190", 
              "https://doi.org/10.1007/s10165-012-0691-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2439", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049875030", 
              "https://doi.org/10.1038/nrc2439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-3083.2011.02536.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050097340"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.r700001200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050432137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cancergencyto.2010.06.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050573999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/cir.0b013e31823ac046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051424218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.186.1.131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051770127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m002285200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052054996"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gks342", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052101846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrcardio.2010.200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052481598", 
              "https://doi.org/10.1038/nrcardio.2010.200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0304-3835(99)00385-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053409458"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.trstmh.2008.01.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054751599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm300915b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055953217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jo00804a007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055986555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1538-7445.am2012-2185", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063242705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.15.11.1882", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063333905"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2009-1719", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064291639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.57.9.1561", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064380274"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1517/14712598.2012.707178", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067588650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1902/jop.2004.75.1.37", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068735047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/156652408785160998", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069185930"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2340/00015555-1228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070751341"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ol.2012.695", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071525638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3899/jrheum.100293", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071542223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cbt.4.3.1497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072293677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.8.17.9416", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072300237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/epi.5.2.10942", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072302979"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "description": "

    The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.

    ", "id": "sg:patent.US-9636328-B2", "keywords": [ "compound", "bromodomains", "invention", "inhibition", "protein function", "binding", "pharmaceutical", "composition", "therapy" ], "name": "Substituted bicyclic compounds as bromodomain inhibitors", "sameAs": [ "https://app.dimensions.ai/details/patent/US-9636328-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-03-07T15:36", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com.uberresearch.data.dev.patents-pipeline/full_run_10/sn-export/5eb3e5a348d7f117b22cc85fb0b02730/0000100128-0000348334/json_export_c65b015e.jsonl", "type": "Patent" } ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-9636328-B2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-9636328-B2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-9636328-B2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-9636328-B2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    550 TRIPLES      13 PREDICATES      174 URIs      16 LITERALS      2 BLANK NODES

    Subject Predicate Object
    1 sg:patent.US-9636328-B2 schema:about anzsrc-for:2464
    2 schema:author Nbc6b2598d2934290bad2c42bb061b9ed
    3 schema:citation sg:pub.10.1007/s00109-011-0837-0
    4 sg:pub.10.1007/s00277-008-0535-3
    5 sg:pub.10.1007/s00296-011-1995-7
    6 sg:pub.10.1007/s00403-010-1033-8
    7 sg:pub.10.1007/s00415-010-5836-5
    8 sg:pub.10.1007/s00417-012-2092-7
    9 sg:pub.10.1007/s00595-010-4300-6
    10 sg:pub.10.1007/s10165-012-0691-0
    11 sg:pub.10.1007/s10753-012-9519-5
    12 sg:pub.10.1007/s10875-012-9706-z
    13 sg:pub.10.1007/s10875-012-9780-2
    14 sg:pub.10.1007/s11164-011-0360-5
    15 sg:pub.10.1007/s13148-011-0026-6
    16 sg:pub.10.1038/29788
    17 sg:pub.10.1038/ajg.2009.271
    18 sg:pub.10.1038/cdd.2011.17
    19 sg:pub.10.1038/mi.2009.5
    20 sg:pub.10.1038/nature09504
    21 sg:pub.10.1038/nature10334
    22 sg:pub.10.1038/nature10351
    23 sg:pub.10.1038/nature10509
    24 sg:pub.10.1038/nrc2439
    25 sg:pub.10.1038/nrc3256
    26 sg:pub.10.1038/nrcardio.2010.200
    27 sg:pub.10.1038/nrd4286
    28 sg:pub.10.1038/sj.cdd.4402008
    29 sg:pub.10.1111/j.1523-1755.2004.00512.x
    30 https://doi.org/10.1002/art.25003
    31 https://doi.org/10.1002/eji.201040391
    32 https://doi.org/10.1002/ibd.20148
    33 https://doi.org/10.1002/ibd.20475
    34 https://doi.org/10.1002/ijc.21669
    35 https://doi.org/10.1002/path.1588
    36 https://doi.org/10.1006/cyto.2002.1039
    37 https://doi.org/10.1016/0272-6386(95)90157-4
    38 https://doi.org/10.1016/j.ajpath.2013.04.020
    39 https://doi.org/10.1016/j.bmcl.2010.07.008
    40 https://doi.org/10.1016/j.bmcl.2012.01.125
    41 https://doi.org/10.1016/j.bmcl.2012.02.041
    42 https://doi.org/10.1016/j.cancergencyto.2010.06.007
    43 https://doi.org/10.1016/j.cell.2011.08.017
    44 https://doi.org/10.1016/j.cell.2012.06.045
    45 https://doi.org/10.1016/j.exer.2010.04.009
    46 https://doi.org/10.1016/j.exphem.2012.08.008
    47 https://doi.org/10.1016/j.febslet.2010.05.030
    48 https://doi.org/10.1016/j.ijcard.2012.01.035
    49 https://doi.org/10.1016/j.jacc.2004.07.047
    50 https://doi.org/10.1016/j.jaut.2010.12.001
    51 https://doi.org/10.1016/j.jaut.2012.07.004
    52 https://doi.org/10.1016/j.joca.2011.01.018
    53 https://doi.org/10.1016/j.jpedsurg.2004.06.015
    54 https://doi.org/10.1016/j.semcancer.2006.07.015
    55 https://doi.org/10.1016/j.tips.2008.03.003
    56 https://doi.org/10.1016/j.tips.2011.12.002
    57 https://doi.org/10.1016/j.trstmh.2008.01.004
    58 https://doi.org/10.1016/j.urology.2006.04.033
    59 https://doi.org/10.1016/s0163-4453(98)91120-3
    60 https://doi.org/10.1016/s0304-3835(99)00385-7
    61 https://doi.org/10.1016/s1044-5323(02)00125-2
    62 https://doi.org/10.1016/s1097-2765(00)80139-2
    63 https://doi.org/10.1021/ja412434f
    64 https://doi.org/10.1021/jm200108t
    65 https://doi.org/10.1021/jm200640v
    66 https://doi.org/10.1021/jm300915b
    67 https://doi.org/10.1021/jm301588r
    68 https://doi.org/10.1021/jo00804a007
    69 https://doi.org/10.1038/emboj.2012.233
    70 https://doi.org/10.1039/c2md20189e
    71 https://doi.org/10.1042/bj20090928
    72 https://doi.org/10.1042/cs20080581
    73 https://doi.org/10.1046/j.1365-4362.2001.01083.x
    74 https://doi.org/10.1073/pnas.1108190108
    75 https://doi.org/10.1073/pnas.1212264109
    76 https://doi.org/10.1074/jbc.m002285200
    77 https://doi.org/10.1074/jbc.m112.359505
    78 https://doi.org/10.1074/jbc.m112.410746
    79 https://doi.org/10.1074/jbc.m112.413047
    80 https://doi.org/10.1074/jbc.r700001200
    81 https://doi.org/10.1080/09629350410001664789
    82 https://doi.org/10.1084/jem.186.1.131
    83 https://doi.org/10.1084/jem.192.6.899
    84 https://doi.org/10.1084/jem.193.6.713
    85 https://doi.org/10.1093/cvr/cvr148
    86 https://doi.org/10.1093/jmcb/mjr042
    87 https://doi.org/10.1093/nar/gks342
    88 https://doi.org/10.1093/nar/gks976
    89 https://doi.org/10.1093/rheumatology/keg459
    90 https://doi.org/10.1093/rheumatology/ken349
    91 https://doi.org/10.1093/rheumatology/ken468
    92 https://doi.org/10.1093/rheumatology/ken489
    93 https://doi.org/10.1097/01.mlg.0000161334.67977.5d
    94 https://doi.org/10.1111/j.0902-4441.2005.t01-1-ejh2437.x
    95 https://doi.org/10.1111/j.1346-8138.1998.tb02375.x
    96 https://doi.org/10.1111/j.1365-2141.2008.07161.x
    97 https://doi.org/10.1111/j.1365-2230.2010.03972.x
    98 https://doi.org/10.1111/j.1365-2249.2009.03947.x
    99 https://doi.org/10.1111/j.1365-2249.2010.04236.x
    100 https://doi.org/10.1111/j.1365-2249.2011.04510.x
    101 https://doi.org/10.1111/j.1365-3083.2011.02536.x
    102 https://doi.org/10.1111/j.1399-3038.2011.01198.x
    103 https://doi.org/10.1111/j.1440-1797.2010.01343.x
    104 https://doi.org/10.1111/j.1601-0825.2005.01165.x
    105 https://doi.org/10.1111/j.1755-148x.2009.00649.x
    106 https://doi.org/10.1128/jvi.00502-06
    107 https://doi.org/10.1128/jvi.01316-08
    108 https://doi.org/10.1128/jvi.02468-08
    109 https://doi.org/10.1136/gut.2005.079343
    110 https://doi.org/10.1158/1538-7445.am2012-2185
    111 https://doi.org/10.1158/2159-8290.cd-11-0220
    112 https://doi.org/10.1159/000237257
    113 https://doi.org/10.1161/01.atv.15.11.1882
    114 https://doi.org/10.1161/01.atv.19.6.1518
    115 https://doi.org/10.1161/01.cir.0000049742.68848.99
    116 https://doi.org/10.1161/cir.0b013e31823ac046
    117 https://doi.org/10.1161/circulationaha.109.872903
    118 https://doi.org/10.1167/iovs.10-6272
    119 https://doi.org/10.1172/jci115411
    120 https://doi.org/10.1172/jci115950
    121 https://doi.org/10.1172/jci5624
    122 https://doi.org/10.1182/blood-2003-06-2116
    123 https://doi.org/10.1182/blood-2008-08-172155
    124 https://doi.org/10.1182/blood-2012-02-413021
    125 https://doi.org/10.1189/jlb.0312165
    126 https://doi.org/10.1196/annals.1372.039
    127 https://doi.org/10.1200/jco.2005.02.8589
    128 https://doi.org/10.1200/jco.2009.26.1347
    129 https://doi.org/10.1210/jc.2009-1719
    130 https://doi.org/10.1212/wnl.57.9.1561
    131 https://doi.org/10.1242/dev.004481
    132 https://doi.org/10.1371/journal.pone.0005903
    133 https://doi.org/10.1371/journal.pone.0018909
    134 https://doi.org/10.1371/journal.pone.0023656
    135 https://doi.org/10.1371/journal.pone.0056514
    136 https://doi.org/10.1371/journal.ppat.1002334
    137 https://doi.org/10.1517/13543784.8.9.1327
    138 https://doi.org/10.1517/14712598.2012.707178
    139 https://doi.org/10.1586/eci.11.7
    140 https://doi.org/10.1634/theoncologist.2010-0212
    141 https://doi.org/10.1634/theoncologist.5-suppl_1-1
    142 https://doi.org/10.1634/theoncologist.5-suppl_1-3
    143 https://doi.org/10.1902/jop.2004.75.1.37
    144 https://doi.org/10.2169/internalmedicine.32.189
    145 https://doi.org/10.2174/156652408785160998
    146 https://doi.org/10.2217/clp.10.37
    147 https://doi.org/10.2340/00015555-1228
    148 https://doi.org/10.2353/ajpath.2009.090319
    149 https://doi.org/10.3109/00207450903428970
    150 https://doi.org/10.3109/00365513.2011.652158
    151 https://doi.org/10.3892/ol.2012.695
    152 https://doi.org/10.3899/jrheum.100293
    153 https://doi.org/10.4161/cbt.4.3.1497
    154 https://doi.org/10.4161/cc.8.17.9416
    155 https://doi.org/10.4161/epi.5.2.10942
    156 schema:description <p id="p-0001" num="0000">The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.</p>
    157 schema:keywords binding
    158 bromodomains
    159 composition
    160 compound
    161 inhibition
    162 invention
    163 pharmaceutical
    164 protein function
    165 therapy
    166 schema:name Substituted bicyclic compounds as bromodomain inhibitors
    167 schema:sameAs https://app.dimensions.ai/details/patent/US-9636328-B2
    168 schema:sdDatePublished 2019-03-07T15:36
    169 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    170 schema:sdPublisher N82a047ef440048918f8e2ffbb6c68da9
    171 sgo:license sg:explorer/license/
    172 sgo:sdDataset patents
    173 rdf:type sgo:Patent
    174 N0440864a7b414dc98f3a334179539a0b schema:name John Frederick Quinn
    175 rdf:type schema:Person
    176 N22ed77d6ac074172a2c19ce924df81b5 rdf:first N3514ded0d4ab4c3d976b5f953e46982b
    177 rdf:rest N863dd5e4fdf5487eb2821a12d7d8dcc6
    178 N3514ded0d4ab4c3d976b5f953e46982b schema:name Ruifang Wang
    179 rdf:type schema:Person
    180 N4c303d8ec90e4910aa764b56982673bd rdf:first N548c6f529b0541908d1a39bf186bae09
    181 rdf:rest N5954d1d2f515405ba0c4a2d1e66047a9
    182 N548c6f529b0541908d1a39bf186bae09 schema:name Gregory Scott Martin
    183 rdf:type schema:Person
    184 N5954d1d2f515405ba0c4a2d1e66047a9 rdf:first N7d69e55580eb427f99bae57a9939fcd6
    185 rdf:rest Nc8739ee050474992831c5fd6b97a66b2
    186 N7608f2d5e4c14806a2b7a493aa3c379f schema:name Gregory Steven Wagner
    187 rdf:type schema:Person
    188 N79a74d57468a48fdbcc5eb40fc9e2161 schema:name Shuang Liu
    189 rdf:type schema:Person
    190 N7d69e55580eb427f99bae57a9939fcd6 schema:name He Zhao
    191 rdf:type schema:Person
    192 N82a047ef440048918f8e2ffbb6c68da9 schema:name Springer Nature - SN SciGraph project
    193 rdf:type schema:Organization
    194 N82eb331c8e4a488ebd5895699cd74964 rdf:first N0440864a7b414dc98f3a334179539a0b
    195 rdf:rest Nb72658d42d3442cd8e6b7e205a66fcb6
    196 N863dd5e4fdf5487eb2821a12d7d8dcc6 rdf:first Nfd44fc6e854f435db9d78af24fa70656
    197 rdf:rest N4c303d8ec90e4910aa764b56982673bd
    198 N86fdd41c012f4816b9cf4927740c3df6 rdf:first N7608f2d5e4c14806a2b7a493aa3c379f
    199 rdf:rest N97e12b7a239f4828a2158b03677947ef
    200 N919bc7bd10874292b3582a0f522e842e schema:name Peter Ronald Young
    201 rdf:type schema:Person
    202 N97e12b7a239f4828a2158b03677947ef rdf:first N919bc7bd10874292b3582a0f522e842e
    203 rdf:rest rdf:nil
    204 N9a8835bfcb734910b9537a1bad04931c schema:name Bryan Cordell Duffy
    205 rdf:type schema:Person
    206 Nb72658d42d3442cd8e6b7e205a66fcb6 rdf:first N9a8835bfcb734910b9537a1bad04931c
    207 rdf:rest N22ed77d6ac074172a2c19ce924df81b5
    208 Nbc6b2598d2934290bad2c42bb061b9ed rdf:first N79a74d57468a48fdbcc5eb40fc9e2161
    209 rdf:rest N82eb331c8e4a488ebd5895699cd74964
    210 Nc8739ee050474992831c5fd6b97a66b2 rdf:first Ncacd1e7129ca4d4b831b1e3c1de84a6b
    211 rdf:rest N86fdd41c012f4816b9cf4927740c3df6
    212 Ncacd1e7129ca4d4b831b1e3c1de84a6b schema:name Michael Ellis
    213 rdf:type schema:Person
    214 Nfd44fc6e854f435db9d78af24fa70656 schema:name May Xiaowu JIANG
    215 rdf:type schema:Person
    216 anzsrc-for:2464 schema:inDefinedTermSet anzsrc-for:
    217 rdf:type schema:DefinedTerm
    218 sg:pub.10.1007/s00109-011-0837-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015571426
    219 https://doi.org/10.1007/s00109-011-0837-0
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1007/s00277-008-0535-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012819123
    222 https://doi.org/10.1007/s00277-008-0535-3
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1007/s00296-011-1995-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012271508
    225 https://doi.org/10.1007/s00296-011-1995-7
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1007/s00403-010-1033-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031744711
    228 https://doi.org/10.1007/s00403-010-1033-8
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1007/s00415-010-5836-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006471313
    231 https://doi.org/10.1007/s00415-010-5836-5
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1007/s00417-012-2092-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000193718
    234 https://doi.org/10.1007/s00417-012-2092-7
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1007/s00595-010-4300-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024739436
    237 https://doi.org/10.1007/s00595-010-4300-6
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1007/s10165-012-0691-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049708190
    240 https://doi.org/10.1007/s10165-012-0691-0
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1007/s10753-012-9519-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000105909
    243 https://doi.org/10.1007/s10753-012-9519-5
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1007/s10875-012-9706-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1003227365
    246 https://doi.org/10.1007/s10875-012-9706-z
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1007/s10875-012-9780-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017371763
    249 https://doi.org/10.1007/s10875-012-9780-2
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1007/s11164-011-0360-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023757810
    252 https://doi.org/10.1007/s11164-011-0360-5
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1007/s13148-011-0026-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010293021
    255 https://doi.org/10.1007/s13148-011-0026-6
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/29788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037262209
    258 https://doi.org/10.1038/29788
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/ajg.2009.271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014339508
    261 https://doi.org/10.1038/ajg.2009.271
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/cdd.2011.17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003477526
    264 https://doi.org/10.1038/cdd.2011.17
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/mi.2009.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023802098
    267 https://doi.org/10.1038/mi.2009.5
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/nature09504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001851540
    270 https://doi.org/10.1038/nature09504
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/nature10334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030076294
    273 https://doi.org/10.1038/nature10334
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/nature10351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019649945
    276 https://doi.org/10.1038/nature10351
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/nature10509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026728956
    279 https://doi.org/10.1038/nature10509
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/nrc2439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049875030
    282 https://doi.org/10.1038/nrc2439
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/nrc3256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044768219
    285 https://doi.org/10.1038/nrc3256
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/nrcardio.2010.200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052481598
    288 https://doi.org/10.1038/nrcardio.2010.200
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1038/nrd4286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038849480
    291 https://doi.org/10.1038/nrd4286
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1038/sj.cdd.4402008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034892015
    294 https://doi.org/10.1038/sj.cdd.4402008
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1111/j.1523-1755.2004.00512.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014853341
    297 https://doi.org/10.1111/j.1523-1755.2004.00512.x
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1002/art.25003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019537340
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1002/eji.201040391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014845015
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1002/ibd.20148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006405097
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1002/ibd.20475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043470749
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1002/ijc.21669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032406417
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1002/path.1588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040719033
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1006/cyto.2002.1039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017471537
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/0272-6386(95)90157-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018352557
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/j.ajpath.2013.04.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040308342
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/j.bmcl.2010.07.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038018165
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/j.bmcl.2012.01.125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013024286
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/j.bmcl.2012.02.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002626433
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/j.cancergencyto.2010.06.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050573999
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/j.cell.2011.08.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026115083
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1016/j.cell.2012.06.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004883182
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1016/j.exer.2010.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032933636
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1016/j.exphem.2012.08.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037688825
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1016/j.febslet.2010.05.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030271685
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1016/j.ijcard.2012.01.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046016453
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1016/j.jacc.2004.07.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013250329
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1016/j.jaut.2010.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006498064
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1016/j.jaut.2012.07.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004684624
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1016/j.joca.2011.01.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008108537
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1016/j.jpedsurg.2004.06.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017597625
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1016/j.semcancer.2006.07.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026605265
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1016/j.tips.2008.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042076553
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1016/j.tips.2011.12.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006448003
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1016/j.trstmh.2008.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054751599
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1016/j.urology.2006.04.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021403224
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1016/s0163-4453(98)91120-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043428808
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1016/s0304-3835(99)00385-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053409458
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1016/s1044-5323(02)00125-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011548907
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1016/s1097-2765(00)80139-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031994520
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1021/ja412434f schema:sameAs https://app.dimensions.ai/details/publication/pub.1031849993
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1021/jm200108t schema:sameAs https://app.dimensions.ai/details/publication/pub.1025618144
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1021/jm200640v schema:sameAs https://app.dimensions.ai/details/publication/pub.1014962424
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1021/jm300915b schema:sameAs https://app.dimensions.ai/details/publication/pub.1055953217
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1021/jm301588r schema:sameAs https://app.dimensions.ai/details/publication/pub.1044763054
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1021/jo00804a007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055986555
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1038/emboj.2012.233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049083427
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1039/c2md20189e schema:sameAs https://app.dimensions.ai/details/publication/pub.1015340401
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1042/bj20090928 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021145702
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1042/cs20080581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046352368
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1046/j.1365-4362.2001.01083.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007496941
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1073/pnas.1108190108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041102152
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1073/pnas.1212264109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037215264
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1074/jbc.m002285200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052054996
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1074/jbc.m112.359505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043907936
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1074/jbc.m112.410746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028060443
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1074/jbc.m112.413047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012692612
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1074/jbc.r700001200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050432137
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1080/09629350410001664789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031710049
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1084/jem.186.1.131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051770127
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1084/jem.192.6.899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002841485
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1084/jem.193.6.713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011193667
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1093/cvr/cvr148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021560410
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1093/jmcb/mjr042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028673905
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1093/nar/gks342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052101846
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1093/nar/gks976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027886931
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1093/rheumatology/keg459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000348279
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1093/rheumatology/ken349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036238315
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1093/rheumatology/ken468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027277171
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1093/rheumatology/ken489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047619133
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1097/01.mlg.0000161334.67977.5d schema:sameAs https://app.dimensions.ai/details/publication/pub.1009886926
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1111/j.0902-4441.2005.t01-1-ejh2437.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022212451
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1111/j.1346-8138.1998.tb02375.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001138030
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1111/j.1365-2141.2008.07161.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008259678
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1111/j.1365-2230.2010.03972.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009161445
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1111/j.1365-2249.2009.03947.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007613291
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1111/j.1365-2249.2010.04236.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049628585
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1111/j.1365-2249.2011.04510.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008703005
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1111/j.1365-3083.2011.02536.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050097340
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1111/j.1399-3038.2011.01198.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015419314
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1111/j.1440-1797.2010.01343.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036626853
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1111/j.1601-0825.2005.01165.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022309784
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1111/j.1755-148x.2009.00649.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023027036
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1128/jvi.00502-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044978788
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1128/jvi.01316-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012491569
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1128/jvi.02468-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010336351
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1136/gut.2005.079343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043790509
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1158/1538-7445.am2012-2185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063242705
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1158/2159-8290.cd-11-0220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039610161
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1159/000237257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036213454
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1161/01.atv.15.11.1882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063333905
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1161/01.atv.19.6.1518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013661868
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1161/01.cir.0000049742.68848.99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011078906
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1161/cir.0b013e31823ac046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051424218
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1161/circulationaha.109.872903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013624700
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1167/iovs.10-6272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047056364
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1172/jci115411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016321463
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1172/jci115950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042252284
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1172/jci5624 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046321148
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1182/blood-2003-06-2116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039291918
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1182/blood-2008-08-172155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031848248
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1182/blood-2012-02-413021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043680109
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.1189/jlb.0312165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027321056
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.1196/annals.1372.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000129161
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.1200/jco.2005.02.8589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020057203
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.1200/jco.2009.26.1347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032892538
    496 rdf:type schema:CreativeWork
    497 https://doi.org/10.1210/jc.2009-1719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064291639
    498 rdf:type schema:CreativeWork
    499 https://doi.org/10.1212/wnl.57.9.1561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064380274
    500 rdf:type schema:CreativeWork
    501 https://doi.org/10.1242/dev.004481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001424180
    502 rdf:type schema:CreativeWork
    503 https://doi.org/10.1371/journal.pone.0005903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046254323
    504 rdf:type schema:CreativeWork
    505 https://doi.org/10.1371/journal.pone.0018909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002616102
    506 rdf:type schema:CreativeWork
    507 https://doi.org/10.1371/journal.pone.0023656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000155499
    508 rdf:type schema:CreativeWork
    509 https://doi.org/10.1371/journal.pone.0056514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012394551
    510 rdf:type schema:CreativeWork
    511 https://doi.org/10.1371/journal.ppat.1002334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043816338
    512 rdf:type schema:CreativeWork
    513 https://doi.org/10.1517/13543784.8.9.1327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000394176
    514 rdf:type schema:CreativeWork
    515 https://doi.org/10.1517/14712598.2012.707178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067588650
    516 rdf:type schema:CreativeWork
    517 https://doi.org/10.1586/eci.11.7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026560618
    518 rdf:type schema:CreativeWork
    519 https://doi.org/10.1634/theoncologist.2010-0212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022108823
    520 rdf:type schema:CreativeWork
    521 https://doi.org/10.1634/theoncologist.5-suppl_1-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031700568
    522 rdf:type schema:CreativeWork
    523 https://doi.org/10.1634/theoncologist.5-suppl_1-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032506924
    524 rdf:type schema:CreativeWork
    525 https://doi.org/10.1902/jop.2004.75.1.37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068735047
    526 rdf:type schema:CreativeWork
    527 https://doi.org/10.2169/internalmedicine.32.189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048307603
    528 rdf:type schema:CreativeWork
    529 https://doi.org/10.2174/156652408785160998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069185930
    530 rdf:type schema:CreativeWork
    531 https://doi.org/10.2217/clp.10.37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005849919
    532 rdf:type schema:CreativeWork
    533 https://doi.org/10.2340/00015555-1228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070751341
    534 rdf:type schema:CreativeWork
    535 https://doi.org/10.2353/ajpath.2009.090319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005107085
    536 rdf:type schema:CreativeWork
    537 https://doi.org/10.3109/00207450903428970 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020096258
    538 rdf:type schema:CreativeWork
    539 https://doi.org/10.3109/00365513.2011.652158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011284973
    540 rdf:type schema:CreativeWork
    541 https://doi.org/10.3892/ol.2012.695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071525638
    542 rdf:type schema:CreativeWork
    543 https://doi.org/10.3899/jrheum.100293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071542223
    544 rdf:type schema:CreativeWork
    545 https://doi.org/10.4161/cbt.4.3.1497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072293677
    546 rdf:type schema:CreativeWork
    547 https://doi.org/10.4161/cc.8.17.9416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072300237
    548 rdf:type schema:CreativeWork
    549 https://doi.org/10.4161/epi.5.2.10942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072302979
    550 rdf:type schema:CreativeWork
     




    Preview window. Press ESC to close (or click here)


    ...