Therapeutic uses of modified relaxin polypeptides


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Vadim Kraynov , Nick Knudsen , Amha HEWET , Kristine DE DIOS , Jason PINKSTAFF , Lorraine SULLIVAN

ABSTRACT

Modified relaxin polypeptides and their uses, including therapeutic uses thereof for the treatment of a fibrotic disorder or heart failure are provided. Exemplary embodiments provide for the use of relaxin polypeptides which include one or more amino acid substitutions with natural or non-naturally encoded amino acids, and/or linkage to a water-soluble polymer, such as polyethylene glycol. More... »

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    Modified relaxin polypeptides and their uses, including therapeutic uses thereof for the treatment of a fibrotic disorder or heart failure are provided. Exemplary embodiments provide for the use of relaxin polypeptides which include one or more amino acid substitutions with natural or non-naturally encoded amino acids, and/or linkage to a water-soluble polymer, such as polyethylene glycol.

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