Method for determining fetal chromosomal abnormality


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Fuman Jiang , Huifei Chen , Xianghua Chai , Yuying Yuan , Xiuqing Zhang , Fang Chen

ABSTRACT

The current invention is directed to methods for noninvasive detection of fetal genetic abnormalities by large-scale sequencing of nucleotides from maternal biological sample. Further provided are methods to remove GC bias from the sequencing results according to the difference in GC content of a chromosome. The current invention not only makes the detection much more accurate but also represents a comprehensive method for fetal aneuploidy detection including sex chromosome disorders such as XO, XXX, XXY, and XYY, etc. More... »

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