Small molecule bicyclic and tricyclic CFTR correctors


Ontology type: sgo:Patent     


Patent Info

DATE

2017-01-17T00:00

AUTHORS

SCHWIEBERT ERIK , STREIFF JOHN , DIXON JOHN , GAO HONGWU

ABSTRACT

Novel CFTR corrector compounds that are effective in rescuing halide efflux, delF508-CFTR protein processing, and apical functional chloride ion transport in a cell are provided. Also provided are methods for treating protein folding disorders (e.g., cystic fibrosis). The methods include administering a CFTR corrector compound or pharmaceutically acceptable salt or prodrug thereof. Methods of rescuing halide efflux in a cell, correcting a processing defect of a delF508-CFTR protein in a cell, and correcting functional delF508-CFTR chloride channels in a cell are also provided. More... »

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