Method of treating cancer by administering a monoclonal antibody that binds human NOTCH2 and NOTCH3


Ontology type: sgo:Patent     


Patent Info

DATE

2016-11-29T00:00

AUTHORS

GURNEY AUSTIN L , HOEY TIMOTHY CHARLES , VAN DER HORST EDWARD THEIN HTUN , SATO AARON KEN , LIU YUAN CHING , BRUHNS MAUREEN FITCH , LEWICKI JOHN A

ABSTRACT

The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth. More... »

Related SciGraph Publications

  • 1998-05. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain in NATURE
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  • 2009-04-09. NOTCH inhibition and glucocorticoid therapy in T-cell acute lymphoblastic leukemia in LEUKEMIA
  • 2004-08-16. Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells in BREAST CANCER RESEARCH
  • 1996-10. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia in NATURE
  • 1994-02. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice in NATURE
  • 2007-08-11. Notch and cancer: a double-edged sword in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2005-06-06. Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells in ONCOGENE
  • 2002-08-19. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells in NATURE MEDICINE
  • 2007-01-12. Asymmetric localization of Notch2 on the microvillous surface in choroid plexus epithelial cells in HISTOCHEMISTRY AND CELL BIOLOGY
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  • 2000-11. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling in NATURE MEDICINE
  • 1996-03. Human Antibodies with Sub-nanomolar Affinities Isolated from a Large Non-immunized Phage Display Library in NATURE BIOTECHNOLOGY
  • 1975-08. Continuous cultures of fused cells secreting antibody of predefined specificity in NATURE
  • 1988-03. Reshaping human antibodies for therapy in NATURE
  • 2005-01-23. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance in NATURE IMMUNOLOGY
  • 1991-08. Making antibody fragments using phage display libraries in NATURE
  • 2000-06-29. Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays in ONCOGENE
  • 2007-04-01. Structural basis for autoinhibition of Notch in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2005-06. Notch signals control the fate of immature progenitor cells in the intestine in NATURE
  • 2001-11. Stem cells, cancer, and cancer stem cells in NATURE
  • 2012-05-25. Role of stromal cell-mediated Notch signaling in CLL resistance to chemotherapy in BLOOD CANCER JOURNAL
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  • 2000-01-13. Identification of a novel NOTCH-4/INT-3 RNA species encoding an activated gene product in certain human tumor cell lines in ONCOGENE
  • 1999-10. Defining epitopes: It's not as easy as it seems in NATURE BIOTECHNOLOGY
  • 2002-04-29. Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing in BMC DERMATOLOGY
  • 2003-09-29. Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents in ONCOGENE
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  • 2004-06-09. Tumor stem cells in PATHOLOGY & ONCOLOGY RESEARCH
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  • 2010-04. Therapeutic antibody targeting of individual Notch receptors in NATURE
  • 2008-09-01. Notch3: from subtle structural differences to functional diversity in ONCOGENE
  • 2005-08-23. The Notch pathway in ovarian carcinomas and adenomas in BRITISH JOURNAL OF CANCER
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