Compounds for treating infectious diseases


Ontology type: sgo:Patent     


Patent Info

DATE

2016-11-29T00:00

AUTHORS

MCLELLAN CATHERINE , MAZITSCHEK RALPH , WHITESELL LUKE , LINDQUIST SUSAN L

ABSTRACT

The present invention provides compounds of Formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting fungal or parasitic growth. The compounds are useful as inhibitors of glycosylphosphatidylinositol (GPI)-anchor biosynthesis, in particular, as inhibitors of fungal Gwt1 activity. The present invention further provides methods of using the compounds described herein for treating fungal or parasitic infections. The compounds can also be used as biological probes to study the effects of inhibiting Gwt1 activity. More... »

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