Methods and compositions for growth of cells and embryonic tissue on a synthetic polymer matrix


Ontology type: sgo:Patent     


Patent Info

DATE

2016-11-08T00:00

AUTHORS

Gary D. Smith , Joerg Lahann , Himabindu Nandivada , Thomas Eyster , Luis Villa Diaz , Paul Krebsbach

ABSTRACT

The present invention provides methods and compositions for establishing and maintaining growth of cells and embryonic tissue on a synthetic polymer matrix. For example, the present invention provides synthetic growth matrices for stem cells, gametes, mature differentiated cells, and embryonic tissue (e.g., blastomeres, embryos, and embryoid bodies). In certain embodiments, the cells are capable of going through multiple passages while remaining in an undifferentiated state as a result of the synthetic polymer matrix. More... »

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2581", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "Gary D. Smith", 
        "type": "Person"
      }, 
      {
        "name": "Joerg Lahann", 
        "type": "Person"
      }, 
      {
        "name": "Himabindu Nandivada", 
        "type": "Person"
      }, 
      {
        "name": "Thomas Eyster", 
        "type": "Person"
      }, 
      {
        "name": "Luis Villa Diaz", 
        "type": "Person"
      }, 
      {
        "name": "Paul Krebsbach", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1530/rep.1.01079", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000899170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.colsurfb.2004.03.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004567815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1263/jbb.102.304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005869616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt922", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005956847", 
          "https://doi.org/10.1038/nbt922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt922", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005956847", 
          "https://doi.org/10.1038/nbt922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1095/biolreprod.102.012583", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006236439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biocel.2005.12.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006277627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.20897", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006368884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1095/biolreprod.103.021147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007519570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.theriogenology.2010.04.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007552463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2004-0279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008652652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.11.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010904856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.11.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010904856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.colsurfb.2004.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011562447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1631", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013244477", 
          "https://doi.org/10.1038/ng1631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1631", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013244477", 
          "https://doi.org/10.1038/ng1631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1001-971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014515248", 
          "https://doi.org/10.1038/nbt1001-971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1001-971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014515248", 
          "https://doi.org/10.1038/nbt1001-971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/la063737w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017232796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/la063737w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017232796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.17.7844", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018395893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)66473-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019112974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.200503264", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023989404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.200503264", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023989404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2003.11.143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024426218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.282.5391.1145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028898955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030407065", 
          "https://doi.org/10.1038/nbt1177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030407065", 
          "https://doi.org/10.1038/nbt1177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbm.a.30732", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030682777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2006-0130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035147955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2004.06.081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035148829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3324/haematol.2009.010736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038447781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pmic.200401087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040025220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2004-0137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048582243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molehr/gal091", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048851416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jez.535", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049055947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jez.535", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049055947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2144/05386st01", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069097105"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-11-08T00:00", 
    "description": "

The present invention provides methods and compositions for establishing and maintaining growth of cells and embryonic tissue on a synthetic polymer matrix. For example, the present invention provides synthetic growth matrices for stem cells, gametes, mature differentiated cells, and embryonic tissue (e.g., blastomeres, embryos, and embryoid bodies). In certain embodiments, the cells are capable of going through multiple passages while remaining in an undifferentiated state as a result of the synthetic polymer matrix.

", "id": "sg:patent.US-9487750-B2", "keywords": [ "method", "composition", "cell", "embryonic tissue", "synthetic polymer", "invention", "matrix", "stem cell", "gamete", "differentiated cell", "blastomere", "Embryonic Structure", "embryoid body", "embodiment", "multiple passage", "undifferentiated state" ], "name": "Methods and compositions for growth of cells and embryonic tissue on a synthetic polymer matrix", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.214458.e", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-9487750-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-04-18T10:18", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com-uberresearch-data-patents-target-20190320-rc/data/sn-export/402f166718b70575fb5d4ffe01f064d1/0000100128-0000352499/json_export_01358.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-9487750-B2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-9487750-B2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-9487750-B2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-9487750-B2'


 

This table displays all metadata directly associated to this object as RDF triples.

152 TRIPLES      15 PREDICATES      60 URIs      24 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-9487750-B2 schema:about anzsrc-for:2581
2 schema:author Nab5ba17989434e2aabccf56f6181b2e0
3 schema:citation sg:pub.10.1038/nbt1001-971
4 sg:pub.10.1038/nbt1177
5 sg:pub.10.1038/nbt922
6 sg:pub.10.1038/ng1631
7 https://doi.org/10.1002/anie.200503264
8 https://doi.org/10.1002/jbm.a.30732
9 https://doi.org/10.1002/jcb.20897
10 https://doi.org/10.1002/jez.535
11 https://doi.org/10.1002/pmic.200401087
12 https://doi.org/10.1016/j.bbrc.2003.11.143
13 https://doi.org/10.1016/j.biocel.2005.12.014
14 https://doi.org/10.1016/j.cell.2007.11.019
15 https://doi.org/10.1016/j.colsurfb.2004.01.005
16 https://doi.org/10.1016/j.colsurfb.2004.03.016
17 https://doi.org/10.1016/j.neuroscience.2004.06.081
18 https://doi.org/10.1016/j.theriogenology.2010.04.020
19 https://doi.org/10.1016/s0140-6736(05)66473-2
20 https://doi.org/10.1021/la063737w
21 https://doi.org/10.1073/pnas.92.17.7844
22 https://doi.org/10.1093/molehr/gal091
23 https://doi.org/10.1095/biolreprod.102.012583
24 https://doi.org/10.1095/biolreprod.103.021147
25 https://doi.org/10.1126/science.282.5391.1145
26 https://doi.org/10.1263/jbb.102.304
27 https://doi.org/10.1530/rep.1.01079
28 https://doi.org/10.1634/stemcells.2004-0137
29 https://doi.org/10.1634/stemcells.2004-0279
30 https://doi.org/10.1634/stemcells.2006-0130
31 https://doi.org/10.2144/05386st01
32 https://doi.org/10.3324/haematol.2009.010736
33 schema:datePublished 2016-11-08T00:00
34 schema:description <p id="p-0001" num="0000">The present invention provides methods and compositions for establishing and maintaining growth of cells and embryonic tissue on a synthetic polymer matrix. For example, the present invention provides synthetic growth matrices for stem cells, gametes, mature differentiated cells, and embryonic tissue (e.g., blastomeres, embryos, and embryoid bodies). In certain embodiments, the cells are capable of going through multiple passages while remaining in an undifferentiated state as a result of the synthetic polymer matrix.</p>
35 schema:keywords Embryonic Structure
36 blastomere
37 cell
38 composition
39 differentiated cell
40 embodiment
41 embryoid body
42 embryonic tissue
43 gamete
44 invention
45 matrix
46 method
47 multiple passage
48 stem cell
49 synthetic polymer
50 undifferentiated state
51 schema:name Methods and compositions for growth of cells and embryonic tissue on a synthetic polymer matrix
52 schema:recipient https://www.grid.ac/institutes/grid.214458.e
53 schema:sameAs https://app.dimensions.ai/details/patent/US-9487750-B2
54 schema:sdDatePublished 2019-04-18T10:18
55 schema:sdLicense https://scigraph.springernature.com/explorer/license/
56 schema:sdPublisher Nb33824f59dd24cf9b6ba175b6adc3431
57 sgo:license sg:explorer/license/
58 sgo:sdDataset patents
59 rdf:type sgo:Patent
60 N20fe7a3d64474aab840bd1dcc92c9447 schema:name Luis Villa Diaz
61 rdf:type schema:Person
62 N2296a4a9662d474389f873ec05a0a525 schema:name Joerg Lahann
63 rdf:type schema:Person
64 N48f4a073ae584c7e9c616b4e7e957723 rdf:first Nefeec5e357da40d5a5a74d9762067aa1
65 rdf:rest Na3456510e78547d8891fb5de439d24f7
66 N6e120bbfaea042f7b0823b898f854acd rdf:first Nfd6f1a74543a41cd854ef8713a673cca
67 rdf:rest N48f4a073ae584c7e9c616b4e7e957723
68 N7b2b9d124a7e4eed9decffa0f50d3422 rdf:first N963dccddf6f14bffba279054e4e449ca
69 rdf:rest rdf:nil
70 N944635a5dfdd42b890ec572b8cd3ea1a schema:name Gary D. Smith
71 rdf:type schema:Person
72 N963dccddf6f14bffba279054e4e449ca schema:name Paul Krebsbach
73 rdf:type schema:Person
74 Na3456510e78547d8891fb5de439d24f7 rdf:first N20fe7a3d64474aab840bd1dcc92c9447
75 rdf:rest N7b2b9d124a7e4eed9decffa0f50d3422
76 Nab5ba17989434e2aabccf56f6181b2e0 rdf:first N944635a5dfdd42b890ec572b8cd3ea1a
77 rdf:rest Nc264e37ceda44c94a2092d7233b7e71f
78 Nb33824f59dd24cf9b6ba175b6adc3431 schema:name Springer Nature - SN SciGraph project
79 rdf:type schema:Organization
80 Nc264e37ceda44c94a2092d7233b7e71f rdf:first N2296a4a9662d474389f873ec05a0a525
81 rdf:rest N6e120bbfaea042f7b0823b898f854acd
82 Nefeec5e357da40d5a5a74d9762067aa1 schema:name Thomas Eyster
83 rdf:type schema:Person
84 Nfd6f1a74543a41cd854ef8713a673cca schema:name Himabindu Nandivada
85 rdf:type schema:Person
86 anzsrc-for:2581 schema:inDefinedTermSet anzsrc-for:
87 rdf:type schema:DefinedTerm
88 sg:pub.10.1038/nbt1001-971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014515248
89 https://doi.org/10.1038/nbt1001-971
90 rdf:type schema:CreativeWork
91 sg:pub.10.1038/nbt1177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030407065
92 https://doi.org/10.1038/nbt1177
93 rdf:type schema:CreativeWork
94 sg:pub.10.1038/nbt922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005956847
95 https://doi.org/10.1038/nbt922
96 rdf:type schema:CreativeWork
97 sg:pub.10.1038/ng1631 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013244477
98 https://doi.org/10.1038/ng1631
99 rdf:type schema:CreativeWork
100 https://doi.org/10.1002/anie.200503264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023989404
101 rdf:type schema:CreativeWork
102 https://doi.org/10.1002/jbm.a.30732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030682777
103 rdf:type schema:CreativeWork
104 https://doi.org/10.1002/jcb.20897 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006368884
105 rdf:type schema:CreativeWork
106 https://doi.org/10.1002/jez.535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049055947
107 rdf:type schema:CreativeWork
108 https://doi.org/10.1002/pmic.200401087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040025220
109 rdf:type schema:CreativeWork
110 https://doi.org/10.1016/j.bbrc.2003.11.143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024426218
111 rdf:type schema:CreativeWork
112 https://doi.org/10.1016/j.biocel.2005.12.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006277627
113 rdf:type schema:CreativeWork
114 https://doi.org/10.1016/j.cell.2007.11.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010904856
115 rdf:type schema:CreativeWork
116 https://doi.org/10.1016/j.colsurfb.2004.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011562447
117 rdf:type schema:CreativeWork
118 https://doi.org/10.1016/j.colsurfb.2004.03.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004567815
119 rdf:type schema:CreativeWork
120 https://doi.org/10.1016/j.neuroscience.2004.06.081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035148829
121 rdf:type schema:CreativeWork
122 https://doi.org/10.1016/j.theriogenology.2010.04.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007552463
123 rdf:type schema:CreativeWork
124 https://doi.org/10.1016/s0140-6736(05)66473-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019112974
125 rdf:type schema:CreativeWork
126 https://doi.org/10.1021/la063737w schema:sameAs https://app.dimensions.ai/details/publication/pub.1017232796
127 rdf:type schema:CreativeWork
128 https://doi.org/10.1073/pnas.92.17.7844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018395893
129 rdf:type schema:CreativeWork
130 https://doi.org/10.1093/molehr/gal091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048851416
131 rdf:type schema:CreativeWork
132 https://doi.org/10.1095/biolreprod.102.012583 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006236439
133 rdf:type schema:CreativeWork
134 https://doi.org/10.1095/biolreprod.103.021147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007519570
135 rdf:type schema:CreativeWork
136 https://doi.org/10.1126/science.282.5391.1145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028898955
137 rdf:type schema:CreativeWork
138 https://doi.org/10.1263/jbb.102.304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005869616
139 rdf:type schema:CreativeWork
140 https://doi.org/10.1530/rep.1.01079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000899170
141 rdf:type schema:CreativeWork
142 https://doi.org/10.1634/stemcells.2004-0137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048582243
143 rdf:type schema:CreativeWork
144 https://doi.org/10.1634/stemcells.2004-0279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008652652
145 rdf:type schema:CreativeWork
146 https://doi.org/10.1634/stemcells.2006-0130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035147955
147 rdf:type schema:CreativeWork
148 https://doi.org/10.2144/05386st01 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069097105
149 rdf:type schema:CreativeWork
150 https://doi.org/10.3324/haematol.2009.010736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038447781
151 rdf:type schema:CreativeWork
152 https://www.grid.ac/institutes/grid.214458.e schema:Organization
 




Preview window. Press ESC to close (or click here)


...