Modified caspase polypeptides and uses thereof


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

David Spencer , Wei-Chun Chang

ABSTRACT

The technology relates in part to compositions comprising modified Caspase-9 polypeptides, compositions comprising nucleic acids coding for modified Caspase-9 polypeptides, chimeric modified Caspase-9 polypeptides, and methods of use thereof, including methods for cell therapy. Methods for cell therapy include modifying transfused cells to express an inducible modified Caspase-9 protein, with reduced basal activity in the absence of the inducer. More... »

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