Modified FGF-21 polypeptides comprising an internal deletion and uses thereof


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Paul E. Morin , Daniel Cohen , Ranjan Mukherjee , Timothy P. REILLY , Rose C. CHRISTIAN , Dasa Lipovsek , Ray Camphausen , John KRUPINSKI

ABSTRACT

Modified FGF-21 polypeptides and uses thereof are provided, for example, for the treatment of diseases associated with fibrosis. Modified FGF-21 polypeptides are disclosed that contain an internal deletion and optionally replacement peptide, optionally modified with at least one non-naturally-encoded amino acid, and/or optionally fused to a fusion partner.

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Modified FGF-21 polypeptides and uses thereof are provided, for example, for the treatment of diseases associated with fibrosis. Modified FGF-21 polypeptides are disclosed that contain an internal deletion and optionally replacement peptide, optionally modified with at least one non-naturally-encoded amino acid, and/or optionally fused to a fusion partner.

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