Assay for inhibitors of CIP/KIP protein degradation


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Anne Marinier , Sylvain Meloche , Benoit Pelletier

ABSTRACT

An assay and system compatible with high throughput screening (HTS) that is capable of identifying inhibitors, such as small-molecule inhibitors, of the degradation of the Cdk inhibitor p21, are described. The assay is based on the use of fusion protein comprising (i) a p2 polypeptide; and (i) a reporter protein linked to the C-terminal of said p21 polypeptide, wherein the fusion protein has a half-life that is similar to that of the p21 polypeptide. Inhibitors identified by this assay may be useful to inhibit the proliferation of tumor cells, and thus for the treatment of cancers. More... »

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