Media for culturing stem cells


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Michal Amit , Joseph Itskovitz-Eldor

ABSTRACT

Well-defined, xeno-free culture media which comprise a TGF-beta isoform or the chimera formed between IL6 and the soluble IL6 receptor (IL6RIL6), which are capable of mainataining stem cells, and particularly, human embryonic stem cells, in an undifferentiated state are provided. Also provided are cell cultures comprising the culture media and the stem cells and methods of expanding and deriving embryonic stem cells in such well-defined, xeno-free culture media. In addition, the present invention provides methods of differentiating ESCs or EBs formed therefrom for the generation of lineage specific cells. More... »

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2995", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2581", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "name": "Michal Amit", 
        "type": "Person"
      }, 
      {
        "name": "Joseph Itskovitz-Eldor", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1634/stemcells.22-5-770", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006193081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1095/biolreprod.102.012583", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006236439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biocel.2005.12.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006277627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1095/biolreprod.103.021147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007519570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.22-4-522", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013925560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2011.325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014016818", 
          "https://doi.org/10.1038/nprot.2011.325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.21-2-131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014191723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1001-971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014515248", 
          "https://doi.org/10.1038/nbt1001-971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/excr.1994.1338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016443136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)66473-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019112974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmsr040330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022304644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030407065", 
          "https://doi.org/10.1038/nbt1177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jbiotec.2007.01.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032284249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.12.13.2048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033063759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0925-4773(94)90030-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043243413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12015-010-9149-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043988237", 
          "https://doi.org/10.1007/s12015-010-9149-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2004-0211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045135667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.2000.9912", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053693663"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "description": "

Well-defined, xeno-free culture media which comprise a TGF-beta isoform or the chimera formed between IL6 and the soluble IL6 receptor (IL6RIL6), which are capable of mainataining stem cells, and particularly, human embryonic stem cells, in an undifferentiated state are provided. Also provided are cell cultures comprising the culture media and the stem cells and methods of expanding and deriving embryonic stem cells in such well-defined, xeno-free culture media. In addition, the present invention provides methods of differentiating ESCs or EBs formed therefrom for the generation of lineage specific cells.

", "id": "sg:patent.US-9404079-B2", "keywords": [ "medium", "stem cell", "culture medium", "beta isoforms", "Chimera", "Interleukin-6", "receptor", "human embryonic stem cell", "undifferentiated state", "Cell Culture Technique", "method", "embryonic stem cell", "invention", "ESC", "generation", "specific cell" ], "name": "Media for culturing stem cells", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.6451.6", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-9404079-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-03-07T15:36", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com.uberresearch.data.dev.patents-pipeline/full_run_10/sn-export/5eb3e5a348d7f117b22cc85fb0b02730/0000100128-0000348334/json_export_c65b015e.jsonl", "type": "Patent" } ]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/patent.US-9404079-B2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/patent.US-9404079-B2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/patent.US-9404079-B2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/patent.US-9404079-B2'


 

This table displays all metadata directly associated to this object as RDF triples.

102 TRIPLES      14 PREDICATES      48 URIs      23 LITERALS      2 BLANK NODES

Subject Predicate Object
1 sg:patent.US-9404079-B2 schema:about anzsrc-for:2581
2 anzsrc-for:2995
3 schema:author Ncad75d8ceee8447b9daafa00ed657422
4 schema:citation sg:pub.10.1007/s12015-010-9149-y
5 sg:pub.10.1038/nbt1001-971
6 sg:pub.10.1038/nbt1177
7 sg:pub.10.1038/nprot.2011.325
8 https://doi.org/10.1006/dbio.2000.9912
9 https://doi.org/10.1006/excr.1994.1338
10 https://doi.org/10.1016/0925-4773(94)90030-2
11 https://doi.org/10.1016/j.biocel.2005.12.014
12 https://doi.org/10.1016/j.jbiotec.2007.01.006
13 https://doi.org/10.1016/s0140-6736(05)66473-2
14 https://doi.org/10.1056/nejmsr040330
15 https://doi.org/10.1095/biolreprod.102.012583
16 https://doi.org/10.1095/biolreprod.103.021147
17 https://doi.org/10.1101/gad.12.13.2048
18 https://doi.org/10.1634/stemcells.2004-0211
19 https://doi.org/10.1634/stemcells.21-2-131
20 https://doi.org/10.1634/stemcells.22-4-522
21 https://doi.org/10.1634/stemcells.22-5-770
22 schema:description <p id="p-0001" num="0000">Well-defined, xeno-free culture media which comprise a TGF-beta isoform or the chimera formed between IL6 and the soluble IL6 receptor (IL6RIL6), which are capable of mainataining stem cells, and particularly, human embryonic stem cells, in an undifferentiated state are provided. Also provided are cell cultures comprising the culture media and the stem cells and methods of expanding and deriving embryonic stem cells in such well-defined, xeno-free culture media. In addition, the present invention provides methods of differentiating ESCs or EBs formed therefrom for the generation of lineage specific cells.</p>
23 schema:keywords Cell Culture Technique
24 Chimera
25 ESC
26 Interleukin-6
27 beta isoforms
28 culture medium
29 embryonic stem cell
30 generation
31 human embryonic stem cell
32 invention
33 medium
34 method
35 receptor
36 specific cell
37 stem cell
38 undifferentiated state
39 schema:name Media for culturing stem cells
40 schema:recipient https://www.grid.ac/institutes/grid.6451.6
41 schema:sameAs https://app.dimensions.ai/details/patent/US-9404079-B2
42 schema:sdDatePublished 2019-03-07T15:36
43 schema:sdLicense https://scigraph.springernature.com/explorer/license/
44 schema:sdPublisher Nfa4e1d05448a4be0b789f58141ffc79c
45 sgo:license sg:explorer/license/
46 sgo:sdDataset patents
47 rdf:type sgo:Patent
48 N5403da0f08e4448b9a785557fe000d0e schema:name Michal Amit
49 rdf:type schema:Person
50 Ncad75d8ceee8447b9daafa00ed657422 rdf:first N5403da0f08e4448b9a785557fe000d0e
51 rdf:rest Ne122838846054118a9381f3198476d73
52 Ne122838846054118a9381f3198476d73 rdf:first Ne80b2e1e22154ac29f54ff7dd85c223b
53 rdf:rest rdf:nil
54 Ne80b2e1e22154ac29f54ff7dd85c223b schema:name Joseph Itskovitz-Eldor
55 rdf:type schema:Person
56 Nfa4e1d05448a4be0b789f58141ffc79c schema:name Springer Nature - SN SciGraph project
57 rdf:type schema:Organization
58 anzsrc-for:2581 schema:inDefinedTermSet anzsrc-for:
59 rdf:type schema:DefinedTerm
60 anzsrc-for:2995 schema:inDefinedTermSet anzsrc-for:
61 rdf:type schema:DefinedTerm
62 sg:pub.10.1007/s12015-010-9149-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1043988237
63 https://doi.org/10.1007/s12015-010-9149-y
64 rdf:type schema:CreativeWork
65 sg:pub.10.1038/nbt1001-971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014515248
66 https://doi.org/10.1038/nbt1001-971
67 rdf:type schema:CreativeWork
68 sg:pub.10.1038/nbt1177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030407065
69 https://doi.org/10.1038/nbt1177
70 rdf:type schema:CreativeWork
71 sg:pub.10.1038/nprot.2011.325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014016818
72 https://doi.org/10.1038/nprot.2011.325
73 rdf:type schema:CreativeWork
74 https://doi.org/10.1006/dbio.2000.9912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053693663
75 rdf:type schema:CreativeWork
76 https://doi.org/10.1006/excr.1994.1338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016443136
77 rdf:type schema:CreativeWork
78 https://doi.org/10.1016/0925-4773(94)90030-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043243413
79 rdf:type schema:CreativeWork
80 https://doi.org/10.1016/j.biocel.2005.12.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006277627
81 rdf:type schema:CreativeWork
82 https://doi.org/10.1016/j.jbiotec.2007.01.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032284249
83 rdf:type schema:CreativeWork
84 https://doi.org/10.1016/s0140-6736(05)66473-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019112974
85 rdf:type schema:CreativeWork
86 https://doi.org/10.1056/nejmsr040330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022304644
87 rdf:type schema:CreativeWork
88 https://doi.org/10.1095/biolreprod.102.012583 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006236439
89 rdf:type schema:CreativeWork
90 https://doi.org/10.1095/biolreprod.103.021147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007519570
91 rdf:type schema:CreativeWork
92 https://doi.org/10.1101/gad.12.13.2048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033063759
93 rdf:type schema:CreativeWork
94 https://doi.org/10.1634/stemcells.2004-0211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045135667
95 rdf:type schema:CreativeWork
96 https://doi.org/10.1634/stemcells.21-2-131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014191723
97 rdf:type schema:CreativeWork
98 https://doi.org/10.1634/stemcells.22-4-522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013925560
99 rdf:type schema:CreativeWork
100 https://doi.org/10.1634/stemcells.22-5-770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006193081
101 rdf:type schema:CreativeWork
102 https://www.grid.ac/institutes/grid.6451.6 schema:Organization
 




Preview window. Press ESC to close (or click here)


...