Methods for inducing selective apoptosis


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Malcolm K. Brenner

ABSTRACT

Provided herein are methods for cell therapy by modifying transfused cells to express an inducible caspase 9 protein, so that the cells may be selectively killed if the patient experiences dangerous side effects. Provided also within relates in part to methods for preventing or treating Graft versus Host Disease by modifying T cells before administration to a patient, so that they may be selectively killed if GvHD develops in the patient. More... »

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        "description": "

    Provided herein are methods for cell therapy by modifying transfused cells to express an inducible caspase 9 protein, so that the cells may be selectively killed if the patient experiences dangerous side effects. Provided also within relates in part to methods for preventing or treating Graft versus Host Disease by modifying T cells before administration to a patient, so that they may be selectively killed if GvHD develops in the patient.

    ", "id": "sg:patent.US-9393292-B2", "keywords": [ "method", "selective apoptosis", "Cell- and Tissue-Based Therapy", "cell", "caspase", "dangerous side effect", "Graft vs Host Disease", "T cell", "Organization and Administration", "patient", "GVHD" ], "name": "Methods for inducing selective apoptosis", "recipient": [ { "id": "https://www.grid.ac/institutes/grid.39382.33", "type": "Organization" } ], "sameAs": [ "https://app.dimensions.ai/details/patent/US-9393292-B2" ], "sdDataset": "patents", "sdDatePublished": "2019-03-07T15:30", "sdLicense": "https://scigraph.springernature.com/explorer/license/", "sdPublisher": { "name": "Springer Nature - SN SciGraph project", "type": "Organization" }, "sdSource": "s3://com.uberresearch.data.dev.patents-pipeline/full_run_10/sn-export/5eb3e5a348d7f117b22cc85fb0b02730/0000100128-0000348334/json_export_0782263a.jsonl", "type": "Patent" } ]
     

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