Inhibitors of influenza viruses replication


Ontology type: sgo:Patent     


Patent Info

DATE

N/A

AUTHORS

Paul S. Charifson , Michael P. Clark , Upul K. Bandarage , Randy S. Bethiel , John J. Court , Hongbo Deng , Ioana Davies , John P. Duffy , Luc J. Farmer , Huai Gao , Wenxin Gu , Dylan H. Jacobs , Joseph M. Kennedy , Mark W. Ledeboer , Brian Ledford , Francois Maltais , Emanuele Perola , Tiansheng Wang , M. Woods Wannamaker , Randal Byrn , Yi Zhou , Chao Lin , Min Jiang , Steven Jones , Ursula A. Germann , Francesco G. Salituro , Ann Dak-Yee Kwong

ABSTRACT

Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle. More... »

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